User talk:AshleyJennings/I-motif DNA/Bibliography

Formation
Formation Intercalated motif (i-motif) DNA is formed in the nuclei of cells via a stack of intercalating hemi-protonated C-neutral C base pairs, which are optimized at a slightly negative pH. [1] In vitro, i-motifs have been characterized with indications that the DNA is derived from telomeres. [2] Using a variety of biophysical techniques, i-motif DNA has been characterized to be derived from centromeres and promoter regions of proto-oncogenes. An analysis of the biophysical results shows the overall stability of the structures is dependent on the number of cytosines in the i-motif core and length and composition of loops in the formation of both intramolecular and intermolecular structures.

Although it has been largely established that C-rich sequences can form i-motif structures in vitro, there is still significant debate regarding the in vivo existence of four-stranded i-motif DNA structure in the human genome. [3] It has been confirmed that-motif DNA in vivo can be formed at physiological pH under certain conditions of molecular crowding and negative superhelicity induced during transcription. Recent studies have shown that the formation of i-motif DNA by specific genomic sequences can occur at neutral pH. Numerous studies have demonstrated that i-motif DNA has an effect on replication and transcription in DNA processing. [4]