User talk:Awtang/Amiodarone induced thyrotoxicosis

Peer Review
Hi, Ashley! This was honestly a great read. It was very comprehensive and had lots of useful information! I learned a lot while reading it and would definitely use this as a quick reference on the wards if this came up in one of my patients. You did a great job breaking everything down to the basics and didn't assume the reader knows everything you know. I made some bullet points with some suggestions for things I would change including some structure of sentences/paragraphs, linking certain vocabulary words, and article structure. The suggestions are in order of when I came across them as I read through the article. I wish there were more wiki articles just like this for all of the obscure diseases that we'll see one day in the hospital so we could reference them.

- Third paragraph, first sentence: "clinically present --> present clinically"

- Move citations outside of the periods (This is how I saw it done in other articles).

- Third paragraph second sentence structuring just to make it read a little easier: "Common symptoms associated with AIT closely resemble symptoms of hyperthyroidism, and they present as include new-onset or recurrence of arrhythmias (add link to arrhytmias), exacerbation of heart conditions such as ischemic heart disease or heart failure, unattributed weight loss, low-grade fever, and restlessness"

- Pathophysiology, paragraph 1- readability changes: As an initial reaction to excess iodine, thyroid reacts according to the auto-regulatory Wolff-Chaikoff effect to prevent an excess of thyroid hormone production, and instead, results in a temporary decrease in thyroid hormone --> Initially, the thyroid reacts by decreasing thyroid hormone production through the auto-regulatory Wolff-Chaikoff effect to prevent an excess of thyroid hormone production.

- Pathophysiology, second paragraph, add a link to cytotoxic, or describe what it is.

- For the last paragraph under pathophysiology it would be a little easier to follow if you made the statements about AIT having delayed presentation at the start of the paragraph followed by the explanation of why it happens.

eg. "AIT often has a delayed clinical presentation. Studies have shown that the average delayed presentation is 2 years.The pharmacology of the drug results in a prolonged half-life within the body as a result of its lipid solubility and distribution into tissues. This leads to a slow clearance of amiodarone from the body and a prolonged toxicity. Other factors affecting AIT include pre-existing heart conditions such as dilated cardiomyopathy and cardiac sarcoidosis, and both have been suggested to be predictive factors for developing AIT."

- AIT type 1: It may be easier to read by non-science people if you avoid words like substrate. Another way to state the same thing would be "... in which the iodine contained in amiodarone is used by the thyroid gland for excess production of thyroid hormones.

- Diagnosis and treatment: In the first sentence, it isn't clear as the reader, what you are referring to by "deleterious effects".

- Diagnosis and treatment, AIT 2: you could add a link for immunologic (I know I kinda overdue to with the links, just to be safe and considerate of readers from all backgrounds).

- Lastly, you could consider splitting the diagnosis and treatment into 2 separate sections, but this is really just up to you. You could also consider adding an image of the structure of amiodarone so we can see where the iodine is present, since its such an important part of why AIT occurs.

Mbraha12 (talk) 04:49, 9 January 2023 (UTC)