User talk:Brendajskarp

I was exposed at home to Permethrin and I am now showing signs of pre-motor Parkinson's disease. When I had a MRI there was scarring of my brain, so there was lasting damage to my brain. I also had a painful case of trigeminal neuralgia. I have contacted SC Johnson, the EPA, and the Maryland Department of Agriculture about this issue. I did not know it was one of the pesticides that caused Parkinsons or Parkinsonism when I was exposed - it wasn't listed in Wikipedia, a Scientific American article I read (I think in 2013), and other sources. After searching here is what I found:

1. In applicators Permethrin greatly increased the risk for developing Parkinsonism or Parkinson’s Disease – in fact more than 3 times the risk. The reference is:

Occupation and Risk of Parkinsonism :  A Multicenter Case-Control Study  Caroline M. Tanner, MD, PhD; G. Webster Ross, MD; Sarah A. Jewell, MD, MPH; Robert A. Hauser, MD; Joseph Jankovic, MD; Stewart A. Factor, DO; Susan Bressman, MD; Amanda Deligtisch, MD; Connie Marras, MD, PhD, FRCPC; Kelly E. Lyons, PhD; Grace S. Bhudhikanok, PhD; Diana F. Roucoux, MPH; Cheryl Meng, MS; Robert D. Abbott, PhD; J. William Langston, MD. [+-] Author Affiliations Author Affiliations: Department of Clinical Research, The Parkinson's Institute, Sunnyvale, California (Drs Tanner, Jewell, Bhudhikanok, and Langston and Mss Roucoux and Meng); Department of Research and Development, Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii (Dr Ross); Department of Neurology, University of South Florida, Tampa, (Dr Hauser); Department of Neurology, Baylor College of Medicine, Houston, Texas (Dr Jankovic); Department of Neurology, Emory University School of Medicine, Atlanta, Georgia (Dr Factor); Department of Neurology, Beth Israel Medical Center, New York, New York (Drs Bressman and Deligtisch); Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada (Dr Marras); Department of Neurology, University of Kansas Medical Center, Kansas City (Dr Lyons); and Department of Statistics, University of Virginia School of Medicine, Charlottesville (Dr Abbott). Arch Neurol. 2009;66(9):1106-1113.doi: 10.1001/archneurol.2009.195.(found at  http://www.ncbi.nlm.nih.gov/pubmed/19752299)

2. A 2006 publication noted this risk for Permethrin and Deltamethrin - Pyrethroid pesticide-induced alterations in dopamine transporter function. Elwan MA1, Richardson JR, Guillot TS,Caudle WM, Miller GW. Toxicol Appl Pharmacol. 2006 Mar 15;211(3):188-97. Epub 2005 Jul 11.(found at http://www.ncbi.nlm.nih.gov/pubmed/16005927)

3. The National Parkinson Foundation has added Permethrin to its list of non-genetic risk factors for Parkinson's Disease (http://www.parkinson.org/understanding-parkinsons/what-is-parkinsons/Environmental-Factors-and-Parkinsons), as well as the Parkinson’s Disease Foundation (http://www.pdf.org/environment_parkinsons_tanner).