User talk:Briggs.ad/sandbox

Peer Review: Ariela Esmurria

-I liked the addition to the end of the first paragraph, in which the article talks about how GABAergic and glutamatergic co-localization is observed in the developing hippocampus. I think that it gives more context to the fact that this happens in in a more specific time point than just occurring all the time. -The restructuring of the second paragraph helps with the flow of the article and the addition of the hyperlinks to other pages is helpful. -Projections: I agree with the idea of moving the technically dense information in the introductory paragraph to this section. I think that it would help to have a more general description at the beginning of the article. -Synaptic terminals: “Large mossy terminals synapse with 11-15 different pyramidal cells and 7-12 mossy cells.” I think the sentence needs to be “Large mossy terminals synapse contain 11-15 different pyramidal cells and 7-12 mossy cells” -Role in learning and memory: Beginning of “It has been shown in rodents” may flow better if the sentence began with “In rodents, it has been shown that….”. The sentence beginning with “The synapses of mossy”, the word specifically can be removed. Bio ace (talk) 15:22, 5 April 2018 (UTC)

Peer review Ken Mochizuki
Summary The mossy fiber pathway is a pathway in the hippocampus that consists of unmyelinated axons. These axons project from the granule cells in the dentate gyrus. Santiago Ramon y Cajal found this pathway and gave the name "mossy" because of its appearance. They are excitatory (glutamatergic) neurons but can also be inhibitory neurons. The granule cells that project the axons for the pathway have synapses that include opiate peptides such as dynophin and enkephalia. The mossy fiber projects from dentate gyrus to CA3 in the hippocampus. In the synaptic terminals, the mossy fibers form multiple synpases with the elaborate dendritic spines of CA3 pyramidal cells (kind of neuron I suppose) in the stratum lucidum of the hippocampus. The three synaptic terminal types are mossy terminals, filopodial extensions, and ex passant synaptic Varicosities. The role of of mossy fiber in memory is that a single mossy fiver projection may make as many as 37 contacts with a single pyramidal cell, and innervates dozen different pyramidal cells.

Major points This article has great depth in understanding, very easy to read and I liked it alot. I liked how the article shows rather than argues a point. The article also comes with a relevant picture that represents the article nicely. Perhaps, revision would be to lessen the use of complex words. Some examples are: • In the introduction the use of varicosities, "These axons were first described as mossy fibers by Santiago Ramón y Cajal as they displayed varicosities along their lengths that gave them a mossy appearance." • In the Anatomy section the use of varicose, hilar, filopodial, pyramidal, and enpassant. These words should be better explained or linked in blue to another article so that the reader can understand the word.

Also the sentence structure in the beginning is wordy. For example, "In the hippocampus, the mossy fiber pathway consists of unmyelinated axons ..." could be changed to perhaps: "The mossy fiber pathway is found in the hippocampus of the brain and consists of unmyelinated axon..."

Minor points: Instead of, "There is also evidence for co-localization of both GABAergic (i.e. inhibitory)... " try "...Inhibitory (I.e. GABAergic)"? — Preceding unsigned comment added by Com.gree (talk • contribs) 04:38, 11 April 2018 (UTC)