User talk:Cesrborgia

Hello, all. I have made some major changes to this page. CO is a minor player in GC activation. The integral membrane GCs are activated by external hormones such as ANP and don't have heme prosthetic groups. 'Soluble' GCs (they are usually immobilized in cells) have heme groups, but nitric oxide activation is by far the most physiologically important activating signal; eNOS and nNOS, the two NO synthase signalling isoforms, provide most of this and their expression and localization often mirrors that of sGC. Think about the emphasis some of you have made to CO/medicine; I think it is misleading. ANP, BNP, and NO are much more important.Cesrborgia (talk) 15:31, 27 February 2011 (UTC)