User talk:Chandler.c.ho/sandbox/Terminator (genetics)

"Transcription termination is vital to gene expression and protein functions. Unstoppable transcriptions consume rNTPs and affect gene expression of itself and other genes. Without a termination mechanism in place, additional nucleotide would be  translated into peptide. The additional of unwanted peptides ultimately distort protein conformation and its  functionalities. Loss of functions of cellular proteins is detrimental to cells. This article does not have an expanded  explanation on how rho dependent transcription terminators or rho independent transcription terminators ends transcription.  It briefly touched on the topic. Additional pictures should be incorporated to illustrate these two mechanisms. In the case  of intrinsic transcription terminators, no description of the terminate sequence was shown. A lot more information on  prokaryotic and eukaryotic transcription termination can be appended. Transcription termination is an important aspect of the underlying system of gene expression. Our article should be linked to group B’s eukaryotic transcription in my opinion." -Quoted from Chandler.c.ho on our group page

So I this is the outline I was thinking of

General description
 * we need to find/create a good image to post on the page perhaps showing intrinsic termination and/or eukaryotic

termination Contents Prokaryotic termination
 * Rho independent
 * we can give a brief description with a link to the main article about intrinsic termination
 * Rho dependent
 * requirement of rho which binds to the rho sequence and dislodges the RNA polymerase. Here's a reference

Eukaryotic termination
 * give a brief description including AATAAA sequence that is transcribed and cleaved by a specific endonuclease and then the

addition of polyA with a link to polyadenylation. See Also
 * Transcription (genetics)

References
 * Here are some review articles we can consult

External Links

Oalnafo1 (talk) 02:48, 23 October 2013 (UTC)

Hey chandler.c.ho, the eukaryotic section still needs work which you volunteered to work on. Please let me know if you need help on this section and I will try to help develop it as well. We will be working on the real page now and not on the sandbox page so we can just use this talk page to have constructive discussion. I think I will begin working on a prokaryotic terminator image that can be posted in wikimedia and so we can use them for this page. In addition I will do some further elaboration of the prokaryotic section.64.183.84.198 (talk) 01:22, 10 November 2013 (UTC)