User talk:Chefmikesf/sandbox/Scott W. Lowe

Scott W. Lowe Edit Requests
1.

Please add this image to the Infobox

Add | image =

2.

Please update the lead paragraph. Is update makes the lead paragraph read better and updates Dr. Lowe's current roll at Memorial Sloan Kettering.

Current content:

Scott William Lowe (born October 4, 1963) is the Chair of the Cancer Biology and Genetics Program at Memorial Sloan Kettering Cancer Center and Howard Hughes Medical Institute Investigator.

Proposed Content:

Scott William Lowe (born October 4, 1963) is Chair of the Cancer Biology and Genetics Program in the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center.

3.

Please add two words to the early education section for the readability of the section.

1. Add the word the after the word at in sentence two

2. Remove the word Working from sentence three

4.

Please add as the first sentence to the Career section

While at MIT, he showed that the tumor suppressor p53 is required for the cell death program that occurs in response to cytotoxic agents such as ionizing radiation and DNA-damaging chemotherapies.

5.

Request five helps update the Career section with an accurate account of his work at the Cold Spring Harbor Laboratory on p53.

Current content: He moved from MIT to Cold Spring Harbor Laboratory, starting his own laboratory as an assistant professor there in 1995 and continuing his work on p53. A key outcome of this research was experimental validation of oncogene-induced senescence.

Proposed Content: He moved from MIT to Cold Spring Harbor Laboratory, starting his own laboratory as a Cold Spring Harbor Laboratory Fellow in 1995 and continuing his work on p53. A key outcome of this research was the discovery of a process known as oncogene-induced senescence, which is now a well-established tumor suppressive program.

6.

Please copy-edit for grammar

Copy edit "His laboratory's" to "His laboratories" for proper grammar

7.

Current Content: He eventually became Deputy Director of the Cancer Center. Much of his work has focused on tumor suppressor genes, and their relation to drug resistance after chemotherapy treatment.

Proposed Content: He eventually became Deputy Director of the CSHL Cancer Center. Much of his work has focused on the biological action of tumor suppressor genes, and the consequences of their mutation.

8.

Current Content: He moved to Sloan Kettering in 2011 to lead the department of Cancer Biology and Genetics. He has been an HHMI Investigator since 2005. In 2017, Dr. Lowe was elected to the United States National Academy of Sciences. In 2019, Dr. Lowe was elected to the National Academy of Medicine.

Proposed Content: He is also known for using genome-editing tools such as CRISPR to create valuable mouse models of different cancers. He moved to Memorial Sloan Kettering in 2011 to lead the Cancer Biology and Genetics Program in the Sloan Kettering Institute, where he has recently discovered mechanisms whereby senescence inducing therapies promote cancer cell immune surveillance (Ruscetti nature/cell). In 2015, Lowe continued his use of RNAi to study the tumor suppressor APC in colorectal cancer. He has been an HHMI Investigator since 2005. In 2017, Dr. Lowe was elected to the United States National Academy of Sciences. In 2019, Dr. Lowe was elected to the National Academy of Medicine.

--Chefmikesf (talk) 18:50, 3 August 2020 (UTC)