User talk:Cleichth/sandbox/orthogonal receptor

Draft feedback
Your headings etc. look great - very comprehensive.


 * Some of your sentences need some work. For example the first sentence of your intro:

"Orthogonal ligand-receptors pairs (also known as re-engineered ligand-receptor interfaces or re-engineered enzyme-substrate interactions) are naturally occurring or selectively mutated receptors, and carefully synthesized ligands; so that neither the wild-type receptor or the ligand of the wild type receptor, interact strongly with the new ligand or receptor."

This is really confusing. This is a difficult concept to explain succinctly, but this needs to be restructured so that it makes more sense. For example there's no need for a semicolon in the middle of that first sentence, instead maybe swap this around and say something like "...and carefully synthesized ligands that are engineered such that neither the wild-type...".


 * "An example of orthogonal ligand-receptor interfaces that involve only G-couple protein receptors are RASSL and DREADD." This is the next sentence of your intro. Is it really necessary to state that this example involves only G-coupled protein receptors? What does this tell us about what an orthogonal ligand-receptor pair is -- the example is important, but not the details about that specific example.
 * Watch comma usage - you have a lot of commas where they're not needed.
 * Be careful of spelling! Several errors (occuring -> occurring).

Good start, focus on writing/sentence structure.

Vellichor (talk) 19:02, 4 November 2015 (UTC)