User talk:Davemania

The pathfinder

A theory involving the transportation of a biologically engineered molecular to a site of choice!! Abstract.

In my model I will get my molecule to go to the liver, but through this mechanism you can take it any where you wish to by using different molecules that I will explain about further, the idea is to introduce the molecule that you want, let’s say I want to insert a gene of some sort, if am dealing with hepatic cancer, and I want to treat it through genetic manipulation “gene therapy” which the uniqueness of delivering the molecule to the site of choice is its primary drawback, my theory treats this problem and allow the molecule to advance to that specific site. The theory states that if an organ “X” needs a molecule “Y” for its normal functioning or to manifest its physiological role it will eventually draw this molecule towards it, so my work concentrates on the physiological forces driving a molecule to an organ of choice so here since I’m dealing with the liver I will use sugar molecules to get my molecule into the liver. The molecule that I will be using is a “nanobot” that many models like it have been introduced but none have the same mechanism, what I mean here it that it is possible to engineer this molecule if agreed upon, and I call it “the pathfinder”, but I will refer to it as “P” for short in this paper. P’s characteristics: -	“P” has to have a coat that will traverse the blood stream without being destroyed by the immune system of the body, that is why I thought of Staphylococcus aureus’s golden coat and its resistance toward the engulfment of macrophages and monocytes and so on... So “P” will have an external coat made up of the same components of the golden coat except for teichoic and lipoteichoic acids that have a role in triggering activation of the compliment by alternative pathway thus stimulate the macrophages to secrete cytokines, but it is surly proven that removing the teichoic/lipoteichoic coat will not hinder the coat resistance, this is done just to maintain a safe route. The coat is surly non infectious.

-	To support “P” I need a minimum of four sugar molecules, I have decided on this when I knew that the smallest nanobot created weighs 400 Daltons, while 1 molecule of sugar(glucose) weighs about 180 Daltons so four sugar molecules would be enough to support its journey, so for starters “P” should have four sites for 4 glucose molecules to attach to, now since the liver attaches on the OH of the 6’-carbon this means that the attachment will be with two sites 2’ and 4’ carbon OH, since this is the only way the molecule could keep it flip-flop resonance boat structure as it is found in the body, I also took advantage of the OH ends to create the attachment and I used 2 to enforce it and to make sure that none other than glucose will be attached since it has a unique structure, otherwise if I attach the molecule to 2’ and 3’ carbon of the glucose molecule the boat van der wal effect that the molecule undergo naturally to take the boat conformation would be affected which means that it could alter its physiological pathway.

-	It should have a compartment to fit the molecule or the gene in question, but concerning the gene more sugar molecules should be attached and the bigger the gene sequence the more sugar molecules should be attached to “P”  to support this weight difference, this compartment is associated with an injector for injection of the gene in to the cell.

-	“P” should have retractable dendrites that sense molecular weight concentrations of the cell.

Mechanism: -	What happens is that “P” enters the body with the glucose molecules attached to it, after its injection in the blood, the patient is given high glucose intake to stimulate the liver into taking glucose for storage, so the glucose molecules attached to “P” would also be driven towards the liver, but not just live any other organ that takes glucose, now how should “P” molecule go to the liver not any other organ? Actually the sugar molecule favors the 6’carbon attachment so once it is bound by an organ (X) from this site then it would leave “P” and get absorbed by this organ, so “P” would pick another free glucose molecule, now why doesn’t “p” pick a different molecule that has an OH group? Because none other than glucose has the same molecular weight and attachment site position (remember I attached the glucose molecule from 2 OH sites), glucose unique structure and geometry, besides any other molecule that has different molecular weight won’t be supported by “P”. now back to the answer for the question concerning why go to “LIVER” not other glucose requiring organs, well the answer lies in the molecular components and the unique components of each cell i.e. liver cells differ from pancreatic cells in its components. This job is attained by the dendrites that extend from “P” which sense the molecular concentration of each cell only if this conc. Is compatible with the liver cell conc. info that has been provided to “P” in-vitro before introduction, Then “p” would fix its dendrites on the cells wall and withdraw them coming closer towards the cell and thus activating the injector to inject the gene or molecule, and thus this molecule or gene in question has been injected in to the specific cell.

Davemania (talk) 20:05, 8 March 2009 (UTC)