User talk:David.Throop/Essential fatty acid interactions

Points left to make
 * Popular press sez n-3 is anti-inflamatory, n-6 is inflamatory. But this ignores actions of SC n-6 PUFA.
 * SC n6 puga can elongate to AA, but
 * evidence is contradictory
 * different tissues have variable elongation capabilty. In particular, the neutrophils don't elongate DGLA
 * evidence is that the anti-inflamatory effects of DGLA are much larger than any effect from AA production.
 * effect of linoleic acid is much smaller
 * need to visit all the steps, from
 * storage in cell membrane
 * inflamatory event
 * signal molecule induces triglyceride cleavage
 * free fatty acid
 * COX or 5LO
 * PGEx, 5HPETE
 * Series forms isomers, naming can confuse.
 * Cytochrome P450 products

-- CNS
 * Neurons don't elongate but other cells do.
 * Fraction of the brain lipids that are AA; DHA
 * Relatively little EPA
 * DHA structural in the retina
 * Role of eicosanoids in neural signalling
 * Same messenger and receptors as in inflammation, but a different cause and a different response
 * Asymmetry between n-3/6 in capture
 * Additional rolses of neuroprotectin D, endocanniboids,

Disorders affected by &omega;-3/6 ratio

 * NIH three strongest evidence A
 * NIH many get B.
 * List the C and D as well.
 * List psychiatric and behavior findings.

Do something with the isoprostanes and isofurans

Effects in the human body

 * Contrast eicosanoid signals to other neurohormones.
 * DHA 'side path'