User talk:Dawillus/Systematic Evolution of Ligands by Exponential Enrichment

I had a look at your page and I am quite impressed with it. You put in a lot of effort I can tell. However, I think some of the sentences are a little too long. For example: While chemical synthesis of randomized sequences allows libraries of 4n size, where n is the length of the randomized sequence, with high diversity, meaning the sequences comprising the library are all unique, amplification of these synthesized oligonucleotides can lead to significant loss of pool diversity due to PCR bias and defects in synthesized fragments.[3]

I feel like you could cut the first part (library size) since it is already mentioned in the text above. Otherwise, I think its great although an image might help to better visualize some of the concepts but then again I think you already put in enough effort :).

Best, TerDiv4

Review
Hey,

So overall I'm impressed with your additions. The original article was lacking in a huge amount of information and you've successfully filled a lot of those gaps.

In the "Target Incubation" you may want to split it into two or more sections if you have time. This would allow you to add more on each of the types of results and why specific methods are used to get those results. Also some more wiki articles could be linked. For example: oligonucleotide, DNA, RNA, etc...

Also I know you didn't write a majority of the ssDNA section, but it may be worth reviewing and editing whats in that section. I find it hard to change what other people have added but sometimes it must be done.

Good luck and very well done!

Zaralis (talk) 00:06, 30 October 2018 (UTC)Zach

Hey Willus,

Great job on the article, the amount of info you put in is great. They're all cited too. In general, there is nothing much to complain about in the procedures part, but it would be nice to add a few more notes on it's possible applications and targets. It doesn't have to be a lot though.

Tbatjargal (talk) 13:31, 30 October 2018 (UTC)

Hey Willis This is fantastic work! I'm glad you went into great detail for each of the steps because it allowed me to grasp the concept a bit easier. I also liked how you thoroughly explained some of the terminology allowing for those outside the field to understand exactly whats going on ...most wiki goers. I would actually love to see some clinical applications or research applications that this can be used for. I think you wrote tons and all that would be needed are a few cited examples.

Great work Best Orlando