User talk:Doctorarticle

'''Hiv / Aids Policy Research Doctorarticle (talk) 04:58, 21 February 2009 (UTC) '''

HIV, the virus that causes this disease, Hiv / Aids Policy Research damage the body's defense system (immune system), so that people who suffer from the disease this ability to maintain himself from the attack of the disease to be reduced. Someone who has HIV positive, not necessarily develop AIDS. Many cases in which someone has HIV positive, but did not become sick in a long time. However, HIV in the body will continue to damage the immune system. As a result, viruses, fungi and bacteria that are usually not dangerous to be very dangerous because the immune system damage.

Because the disease is vengeance, the various efforts made to develop drugs that can be overcome. Medicine is being developed at this time, the target is the enzyme-enzyme produced by HIV and needed to be developed by the virus. This enzyme-enzymes are hampered by using the Enzyme inhibitor that will hamper the work of enzymes-enzymes and will ultimately hinder the growth of the HIV virus.

HIV is the virus that genetiknya material is RNA (RNA) that are wrapped with a matrix which consists mainly of protein. To grow, the genetic material is to be converted into DNA (DNA), DNA integrated into the wet nurse, and then to the process that eventually will produce protein. Protein-protein that is produced will then form a baru.Obat-viral drugs that have been found in the currently hamper the conversion RNA to DNA and prevent the formation of protein-protein active. Conversion enzymes that help DNA into RNA called reverse transcriptase, while helping the formation of protein-protein called protease active.

To be able to establish that the active protein, the genetic information stored on the RNA viruses must first be modified DNA. Reverse transcriptase help change the RNA to DNA. If the process of DNA are hampered, then the process of protein also become obstructed. Therefore, the establishment of a new virus that will be slow. Thus, the use of drugs barricade enzyme reverse transcriptase not fully eradicate the virus in the body. The use of drugs of this type only hamper the process of the formation of a new virus, and the process of persecution, can not stop the process of the formation of a new virus in total.

Medicines are now many other developing obstacle is the use of protease enzyme. From the DNA derived from RNA virus, will be formed protein-protein, which will play a role in the process of the formation of new virus particles. In the beginning, protein-protein, which was formed in the shape that is inactive. To activate it, the protein-protein that is produced should be cut in certain places. Here is where the role of protease. Protease will cut the protein in place of certain proteins from DNA formed, and ultimately will produce a protein matrix will be formed from the viral protein (protein structural) or functional proteins that play a role fully as five enzim.Gambar 3 with the structure of enzyme inhibitor of HIV protease Antiretroviral activity in clinical trials. NHtBu = amido tertiary butil and Ph = fenil (Flexner, 1998).

Clinical trials show that a therapy using protease Enzyme inhibitor can reduce the amount of HIV RNA and significantly increase the number of CD4 cells (indicators of the immune system work) during the first week of treatment. However, the ability of this compound for the complex, pressing the replication of viruses is often limited, causing the options that generate HIV resistant to drugs. Therefore, the treatment is done by using the combination therapy together with the Enzyme inhibitor reverse transcriptase. Enzyme inhibitor protease Enzyme inhibitor combined with the reverse transkriptase shows antiviral response that is more significant that can survive in the longer period of time (Patrick & Potts, 1998).

From the description above, we can know that there has been no medicine that can actually cure the disease of HIV / AIDS. Medicines that have been found only hamper the growth of the virus, so the amount of virus can be pressed.

Therefore, the challenge for the researchers in the world (including India) is to find drugs that can damage the virus found in the body, not only hamper the growth of the virus. Indonesia's rich biodiversity, of course, have a huge potential for finding medicines that come from nature. Searching for a complex that requires research that is not simple. Drugs that can be found in Indonesia? Wallahu a'lam.

SYMPTOMS AIDSDoctorarticle (talk) 05:08, 21 February 2009 (UTC)

* Pain tired prolonged * Shortness of breath and cough prolonged * Weight of striking down the Over gland (in the neck, axilla, thigh fold) because without a clear * The speck red on the skin (skin cancer) * Often, fever (more than 38 ° C) with night sweat because without a clear * Diarrhea more than one month without a clear reason