User talk:Dsrapp

Peer Review

Overall the new Wikipedia article on nucleic acid metabolism is much improved. The information added is significantly longer and more in depth without being too scientific and the new figures help illustrate this information. The introduction is accessible, but a little sparse. You may consider adding some information about DNA and other pathways nucleic acids are involved in. In the Purine Synthesis section, the sentence ‘AMP and GMP are then converted into adenine and guanine, respectively’ can go before ‘IMP is then converted to AMP (...)’, so that a better overview of the use of IMP for the production of AMP and GMP is given to the reader. Also, before mentioning the cross-regulation of ATP to GTP a brief sentence on how and why AMP and GMP are further converted to ATP and GTP can be added. In the next section, it seems like a second part of the sentence ‘Thymidine synthesis first requires reduction of the uridine to deoxyuridine’ is missing, a brief overview of the next section could be given to fill the gap. In general, very good job summarizing synthesis of pyrimidines and purines, adding an insight on regulation and giving an example of a disease related to it. The Degradation section could use more details for pyrimidine catabolism, including more specific mechanisms, defects, and use of free pyrimidines to make new nucleotides. Also, the figure in this section mentions intercellular transport, but that is never discussed in the body of the section. There is also a typo in the last sentence of the section on purine catabolism “joints.)”

It may be worth combining the sections on deficiencies and defects into their own section, although it is still easy to follow in the current form.

The figures are very good, but the colors are a little distracting and hard to read in the first two.

Further wikipedia links to be added are xanthine and xanthosine monophosphate.

References are varied and extensive, however an article from a mainstream newsource (perhaps about one of the diseases mentioned) would add more variety. In addition, the references are very representative of the content in the wikipedia page and can be used for further analysis of the pyrimidine salvage pathway. The catabolism of Thymidine can be used as an example in this case for the salvage pathway and to prepare for cell division.

Mbrdgt (talk) 23:32, 22 October 2014 (UTC)mbrdgt anapkut (talk) 18:39, 23 October 2014 (UTC)anapkut