User talk:Ewells2013/sandbox

I plan on expanding on the article that focuses on Atrophin-1. The introduction is only one sentence and the function of the protein can be added to. There are multiple homologs that are used in experiments that could be mentioned. Ewells2013 (talk) 22:45, 16 February 2017 (UTC)

Editing Atrophin-1 article
Atrophin-1 is a protein that in humans is encoded by the ATN1 gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat.[3] The function of Atrophin-1 has not yet been determined.[4] There is evidence provided by studies of Atrophin-1 in animals to suggest it acts as a transcriptional co-repressor.[4] It can be found in the nuclear and cytoplasmic compartments of neurons.[4] It is expressed in nervous tissue. Contents [hide]

1 Function 2 Clinical significance 3 Interactions 4 References 5 Further reading 6 External links '''Function[edit | edit source] '''The function of Atrophin-1 have not been defined yet. It is widely hypothesized that Atrophin-1 functions as a transcriptional co-repressor[5].A transcriptional co-repressor is a protein that indirectly suppresses the activity of specific genes by interacting with DNA-binding proteins[5].''' ''' Clinical significance[edit | edit source] The ATN1 gene has a segment of DNA called the CAG trinucleotide repeat.[5] It is made up of cytosine, adenine, and guanine, and repeats multiple times.[5] The number of CAG repeats in the ATN1 gene in a healthy person will range from six to thirty-five[5] Studies conducted have supported the idea that mutated Atrophin-1 gathers in neurons and disrupts functions of cells[5]. Mutations in ATN1 are associated with a form of trinucleotide repeat disorder known as "dentatorubral-pallidoluysian atrophy" or "dentatorubropallidoluysian atrophy". Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within this gene. The symptoms of this disorder can credited to the significant reduction of brain and spinal tissue observed in those afflicted with "dentatorubral-pallidoluysian atrophy".[6] There are juvenille-onset and late adult-onsets disorders of "dentatorubral-pallidoluysian atrophy" that experience differing degrees of severity in certain symptoms.[6] The edited or added sentences to the article are the ones boldedEwells2013 (talk) 20:54, 25 February 2017 (UTC)

peer review #1
your addition to the article is so helpful, thank you — Preceding unsigned comment added by Rahaf M Hassan91 (talk • contribs) 22:53, 11 March 2017 (UTC)

peer review
This is good content. The only thing I would consider editing is how you phrase the second sentence; you should say the sequence repeats or just combine the first and second sentences. Ddoerflinger (talk) 17:43, 12 March 2017 (UTC)

Okay, thanks for the reviews!. I will try and figure out how to word the second sentence better. Ewells2013 (talk) 14:41, 24 March 2017 (UTC)