User talk:Haleema A

MULTIPOTENT DEFINITION REQUIRES REVISION

RE: An example of a multipotent stem cell is a hematopoietic cell — a blood stem cell that can develop into several types of blood cells, but cannot develop into brain cells or other types of cells.

This dogma of restricted lineage has been challenged with findings that bone marrow-derived cells (from the embryonic mesoderm) can generate neurones (from the embryonic ectoderm).

"Bone marrow contains a heterogeneous population of cells and notably contains at least two stem cell populations: haematopoietic stem cells and mesenchymal stem cells (MSC). Under specific conditions of cell culture, MSC, also termed marrow stromal cells, can adopt a neuronal phenotype (Woodbury et al . 2000, 2002; Bossolasco et al. 2005; Cho et al. 2005; Guo et al. 2005)."

Reference: Hess D. C. and Borlongan C. V. (2008) Stem cells and neurological diseases. Cell Prolif. 41 (Suppl. 1), 94–114 (above reference on P97)