User talk:HelinaSaleh

I am planning to make some changes and update the info on the Chemogenetics Page and I would kindly appreciate your feed back. I have written the preliminary outline below. Thank you.

Chemogenetics

* Indicate the difference between optogenetics and chemogenetics ( i.e., Having more spatiotemporal control . ) Explain how the spatiotemporal control is achieved. * Explain more about the process of designing DREADDs and retro DREADDS.

Benefits : *Pharmacology and treating different diseases : link the information to the diseases page. The targeted diseases in chemogenetics currently consist of neurodegenerative disorders such as Parkinsons disease and neuropsychological disorders such as addiction and anxiety, depression and Schizophrenia. *The advancement of chemogenetics in pain management. ( add osteoarthritis associated pain to the diseases under investigation in this field. )

Animal Models  : * Advancement and limits : explain non primate models used such as rodent models. Discuss the advancement s and limitation of using non human primate models.

Future Direction : * discuss the future directions considered in the literature and how chemogenetics can be incorporated to treat different disorders. HelinaSaleh (talk) 21:24, 11 May 2017 (UTC)

References so far include : 1. Galvan, Adriana; Caiola, Michael J.; Albaugh, Daniel L. (2017-02-25). "Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates". Journal of Neural Transmission: 1–17. doi:10.1007/s00702-017-1697-8. ISSN 0300-9564. Jump up      2. ^ Dobrzanski, Grzegorz; Kossut, Małgorzata (2017-04-01). "Application of the DREADD technique in biomedical brain research". Pharmacological Reports. 69 (2): 213–221. doi:10.1016/j.pharep.2016.10.015. Jump up        3.^ Bang, Juwon; Kim, Hak Yeong; Lee, Hyosang. "Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters". Experimental Neurobiology. 25 (5). doi:10.5607/en.2016.25.5.205. PMC 5081467 Freely accessible. PMID 27790055. Jump up         4.^ Miller, Rachel E.; Ishihara, Shingo; Bhattacharyya, Bula; Delaney, Ada; Menichella, Daniela M.; Miller, Richard J.; Malfait, Anne-Marie (2017-04-01). "Chemogenetic inhibition of pain neurons in a mouse model of osteoarthritis". Arthritis & Rheumatology: n/a–n/a. doi:10.1002/art.40118. ISSN 2326-5205. Jump up           5.^ Fleury Curado, Thomaz; Fishbein, Kenneth; Pho, Huy; Brennick, Michael; Dergacheva, Olga; Sennes, Luiz U.; Pham, Luu V.; Ladenheim, Ellen E.; Spencer, Richard (2017-03-10). "Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency". Scientific Reports. 7. doi:10.1038/srep44392. ISSN 2045-2322. PMC 5345079 Freely accessible. PMID 28281681.