User talk:Jannasophia

--Claudia Castillo Claudia Castillo is a Colombian woman living in Barcelona who, in June 2008, became the first person to receive a section of windpipe grafted from her own stem cells.[1] Ms. Castillo suffered from a collapsed tracheal branch of her windpipe after an infection of tuberculosis, diagnosed in 2004, that left her unable to breathe or perform simple tasks such as climbing stairs or carrying her children.[2] In March 2008, after being admitted to the Hospital Clinic Barcelona, Ms. Castillo was offered two choices, either to have her left lung removed or to take part in an experimental surgery in which she would be the first patient to ever receive a windpipe section that was “engineered” rather than donated.[3] Ms. Castillo chose the latter and a novel procedure began.

Stem cells were removed from the bone marrow in her hip, and the cartilage in her airway and the inside of her nose. These cells were sent back to the University of Bristol where the lab of Professor Martin Birchall grew and matured these into cartilage cells in conjunction with Sally Dickingson and Anthony Hollander, Arthritic Research Campiagn Professor of Rheumatology and Tissue Engineering[7] using a method used for treating osteoarthritis. A trachea was donated by a deceased 51-year-old who had died of cerebral complications. The donated tissue was decellularized over a period of six weeks to remove most donor cells, a process proceeded over by Silvia Bellini, Piro Parnigotto and Maria Conconi of the University of Padua, Italy[7]. The stripped cartilage, now basically a fibrilous scaffold for Ms. Castillo’s host cells, was incubated in a novel bioreactor created at the Politecnico de Milano by Adelaide Aznaghi and Sarah Mantero. After four days, the newly reseeded trachea was grafted to replace Ms. Castillo’s left main bronchus at the Hospital Clinic of the Univesity of Barcelona, Spain, by Professor Paolo Macchiarini. Other Spanish team members included Phillipp Jungebluth, Jaume Martorell, and Tuetsuski Go[7].

Directly after grafting, the transplant was indistinguishable for the adjacent normal bronchi. Ms. Castillo was able to return home ten days following surgery with no need for immunosuppressive drugs.[4] Her lung function has been reported as normal for her age and sex and her immune system shows no signs of rejecting the transplant.[5] One month post-surgery, a biopsy showed local bleeding, indicating that the blood vessels had already grown back successfully.[6]

The study was funded by the Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Fondo de Incestigacion Sanitaria, Spain; Charles Courtenay-Cowlin Fund, University of Bristol; UK Arthritis Research Campaign; and the James Tudor Foundation.[8]

--Jamaree1 (talk) 14:34, 12 December 2008 (UTC)