User talk:KerzNeuroscience/sandbox

Hi, I wanted to give you your feedback on your talk page. Things look great--just make sure your group addresses the comments at the Place Cell page and do a sweep to make sure that you have linked to other pages throughout your section at all opportunities--remember if it is linked earlier in the actual page for place cells, don't link to it again. PCMidd Intro Neuro (talk) 11:34, 4 December 2013 (UTC)

Thank you for your comment! See directly below for the changes I made based on your comment. You can also look below your addressed comment for the changes I made based on peer comments (that had to do with my assigned subtopics for this page):

-Comment from Professor Cronise: make sure that you have linked to other pages throughout your section at all opportunities--remember if it is linked earlier in the actual page for place cells, don't link to it again.

My changes: I went through and added the following links to the already existing links in my sections (see below)

Under introduction:

Cognitive map link to Cognitive map (this is under my partner’s section, but I later mention cognitive maps and wanted to make sure it was linked when first mentioned

Pyramidal link to Pyramidal cell (this is under my partner’s section, but I later mention pyramidal cells and wanted to make sure it was linked when first mentioned)

Under background:

non-spatial memory link to Spatial memory

Delayed non-match-to sample task link to Match-to-sample task

Trauma link to Trauma

Omnidirectionality link to Omnidirectional

Goal-oriented link to Goal-oriented

Landmarks link to Landmark

Cue link to Sensory cue

Under Effects of Ethanol on Place Cell Function:

Chronic link to Chronic

Ethanol link to Ethanol

Tolerance link to Alcohol tolerance

Addictive link to Addiction

Under Effects of Vestibular Lesioning on Place Cell Function:

Inner ear link to Inner ear

Self-motion link to Self-motion

Bilateral link to bilateral

Connectome link to Connectome

Neurotransmission link to Neurotransmission

Neuroanatomy link to Neuroanatomy

Protein expression link to Protein expression (biotechnology)

Under place cells and aging:

Pharmaceuticals link to Pharmaceutical drug

Protein synthesis link to Protein biosynthesis

Senescence link to Senescence

Frequency link to Frequency

Translation link to Translation (biology)

Transcription link to Transcription (genetics)

mRNA link to Messenger RNA

Memory consolidation link to Memory consolidation

CA1 link to Region I of hippocampus proper

CA3 link to Region III of hippocampus proper

CA2 link to Region II of hippocampus proper

Deficits link to Cognitive deficits

Amplitude link to Amplitude

Plasticity link to Neuroplasticity

Glutamate receptors to Glutamate receptor

Antagonist link to Receptor antagonist

Encoding link to Encoding (memory)

Neurogenesis link to Neurogenesis

Comments on my portion of the Background section:

- Look at clarifying description of the delayed non-match-to sample task. Try to use very specific language (especially in the last couple sentences).

My changes: To clarify my description of the delayed non-match-to sample task, I deleted the last couple of sentences and replaced them with more specific language (as seen in bold below) that includes an example of what a visual representation might look like (a block). This task uses flexibility in that the rat is first presented with a visual representation '''such as a block. After a delay, when presented with the block and a novel object, the rat must choose the novel object in order to obtain a reward.'''

- Unclear: “Lesioning experiments attempting to inflict non-spatial memory deficits in the hippocampus have either failed to induce a deficit or induce a deficit using lesioning methods that affect more than just the hippocampus.

My changes: In order to clarify this part, I broke it up into several sentences that have more clear wording and are easier to understand. '''Many lesioning experiments attempting to inflict non-spatial memory deficits in the hippocampus have been unsuccessful. In some cases, lesioning has been successful in inflicting non-spatial memory deficits, however, other structures besides the hippocampus were affected by lesioning. Therefore, the rat’s non-spatial memory deficits could have been unrelated to place cells.'''

-In the last paragraph you say “Future research should investigate whether chronic ethanol exposure produces a functional tolerance to ethanol’s effects and whether there is specificity of place cell firing during the formation of this tolerance.” This seems contradictory to what you said in your second sentence of this section, “Just as lesioning in these structures causes rats to rely on cue-based information to function, so too does chronic ethanol exposure.” Maybe join two idea together to clarify the relationship.

My changes: None. I did not make any changes because I do not see these sentences as contradicting one another. Reliance of cue-based information to function after chronic ethanol exposure does not necessarily mean that functional tolerance has developed. More research would have to be done to determine whether tolerance has developed and if so, whether place cell firing changes during the formation of the tolerance.

-In the third paragraph of the Background the last line says “does not does not”.

My changes: I fixed this typo.

-“The rat hippocampus was biologically designed to provide the rat with spatial information.” This is really interesting but needs a citation or further explanation.

My changes: I completely agree with this comment. The way I phrased this sentence made it seem like it was a fact that would need much more explanation when I meant to say that supporters of the cognitive map theory believe that the rat hippocampus was biologically designed to provide the rat with spatial information. Therefore, I combined the sentence mentioned above with the previous sentence to make it clear that it is a theory associated with the cognitive map theory. I also provided a citation at the end of this sentence as is suggested.

Comments on the Abnormalities section:

-I think the only area in the Abnormalities section that was hard to follow and a little repetitive was the ethanol section. Are there other studies with other gases or just ethanol?

AND

- In regards to the Ethanol section, in the last sentence, “Research should also be done on whether chronic ethanol exposure produces a tolerance to other abused drugs with similar properties”, does this mean that they have only tested for ethanol? Or have other drugs been tested?

My changes: I deleted the following sentences seeing that they were a little bit repetitive and unnecessary: '''Interestingly, studies have shown that repeated exposure to ethanol leads to a similar shift in the rat's needing to rely on non-spatial information to assess its surroundings. The behavior following repeated ethanol exposure can be explained, in part, by changes at a cellular level. Ethanol greatly alters the firing of hippocampal place cells. I also deleted “and before testing on tasks" because I think it makes the argument harder to follow. I also made the following bolded changes: “Research should also be done on whether chronic ethanol exposure produces a tolerance to other abused drugs with similar addictive properties. While research has been conducted on the effects of addictive drugs on spatial memory, there has not been research that investigates whether chronic ethanol exposure would produce tolerance to these drugs in addition to ethanol tolerance.” I added the word “addictive'''" to be more specific about what “similar properties” means. I also added a sentence at the end of the paragraph explaining what has been researched in terms of the effect of addictive drugs on the hippocampus and what should be researched in the future.

-In the Vestibular Lesioning section, is it possible to be more clear about what a vestibular lesion is?

My changes: I added a description of the vestibular system as part of the labyrinth of the inner ear to clarify which structure I am discussing and where it lies in the ear. The “Vestibular system” is also linked to a Wikipedia page so that further research on the vestibular system can be conducted if the reader is interested. I also described lesioning the first time it is mentioned in our article and added a link to the Wikipedia page on lesioning the first time it is mentioned so that readers who want to learn more about what it is can explore that link.

Claire has agreed to address comments about more information on the discovery of place cells because she was assigned this portion of the background.KerzNeuroscience (talk) 20:14, 5 December 2013 (UTC)