User talk:Kwall005/sandbox

Anal pore One issue of this article is that it does not cite any sources. I would look into trying to find at least one source that supports the information stated in this article. I would also look into inserting an image that can help a reader who is not familiar with cellular anatomy. This article may also be confusing to readers with how the authors states one of their sentences. I would attempt to reword the sentence so the reader does not have to question what the author is trying to convey.Kwall005 (talk) 14:57, 18 October 2016 (UTC)

ITPKC

This gene is located at chromosome 19q13.2, it codes for one of three isoenzymes. The other two enzymes being ITPKA and ITPKB. The ITPK enzymes are used to phosphorylate IP3. ITPKC is involved in the Ca(2+)/NFAT pathway negatively regulating T cell activation.

A mutation in this gene occurs through a single-nucleotide polymorphism. When a mutation occurs the gene does not produce a functioning enzyme, meaning it will no longer be effective in negatively regulating T cells. Leading to overly active T cells, having this mutation in ITPKC is correlated to the increased risk of developing symptoms. Kwall005 (talk) 12:39, 1 November 2016 (UTC) Kwall005 (talk) 17:47, 5 November 2016 (UTC)