User talk:Lamyawu

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Hello Lamyawu,

I saw on the history page of the Roundabout (gene) page that you were one of the first editor's to the function portion. I am currently working with a couple others on adding to the page for a research-type project. I was wondering if you could perhaps elaborate a little bit on the details of the source you utilized for the section about actin cytoskeleton regulation. In one of the sources I have, it seems that it is an interaction between the CC3 domain of Robo1 and srGAP1, and then Robo1 binding to Slit that inactivates Cdc42, a member of the small Rho GTPase family that affects and regulates the actin cytoskeleton and cytoskeletal remodeling. In the big picture, it is a Slit/Robo interaction that is affecting the cyctoskeleton structure, but there seem to be some players of the mechanism missing. I think adding in these other details would be good for that specific section of the page, if this information is similar to the source you originally used to write the piece. Thank you!

Kaleinonen (talk) 21:10, 19 April 2012 (UTC)