User talk:Lbates2008/sandbox

Common to all PLC isozymes, PLCG1 consists of an N-terminal PH domain, which translocates PLC to the plasma membrane and binds PIP3 ; four EF hands; an X and Y catalytic region comprising the TIM barrel; and a C-terminal C2 domain. Specific to the PLCG isozymes is a large separation between the X and Y domains consisting of a split PH domain, tandem SH2 domains, and an SH3 domain. The SH2 domains bind phosphorylated tyrosine residues on target proteins via their FLVR sequence motifs, activating the catalytic function of PLCg; and the SH3 domain binds to proline-rich sequences on the target protein. PLCG1 can be activated by receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases. For example, when activated, fibroblast growth factor receptor 1 and epidermal growth factor receptor are RTKs that have phosphorylated tyrosines, which provide docking sites for PLCg1 SH2 domains. The activated RTKs phosphoylate PLCg1 at tyrosines located at position 472, 771, 775, 783, and 1254. Non-receptor tyrosine kinases interact with PLCg1 in large complexes at the plasma membrane. For example, in T cells, Lck and Fyn (Src family kinases) phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the T-cell antigen receptor (TCR). The phosphorylated ITAMs recruit ZAP-70, which phosphorylates tyrosines in LAT and SLP-76. PLCg1 binds to LAT through its n-terminal SH2 domain and to SLP-76 via its SH3 domain .Lbates2008 (talk) 01:47, 9 March 2017 (UTC)

I think you should've posted your draft in the sandbox. I think. Besides that, I didn't really understood the second sentence of the second paragraph. If you could fix the flow that would be awesome. Ncameron2013 (talk) 19:07, 12 March 2017 (UTC)NCameron2013

I agree with the above Wikipedian that you'd have done edits in the sandbox. About the edits, I think you have done a good job overall with adding detailed information about structure in straight and simple words with proper citations. KP 0503 (talk) 06:22, 12 April 2017 (UTC)kp0503