User talk:Lcuomo411/I-motif

MZF- What does constantly forming and dissociating mean? Under what conditions? Can you specify in more detail the role of i motif? You use the word "cytosine-staurated"? Not clear. Try to consolidate some sentences. For example, pH sentences. Can you expand on how structure forms at neutral pH or biological conditions? What conditions?

Not clear the significance of NMR results.

Is there a significance to this section?

"Using the genomic sequences found in various organism, such as the tetrahymena species, the sequence found in the genome, [CCCCAAA]3CCCC, had the capability to form the tetramic complex. This formation was compared to the formation of the synthesized oligodeoxynucleotides, which introduced the idea that these complexes had the capability of forming within organisms."

The following parts might go above? Based on the data, the stability of these structures is is dependent of the number cytosine residues that are interacting with each other. This means that as more cytosine residues interact through hydrogen bonding, the more stable the molecule will be.

These structures have been discovered in many different locations of the cell including the nuclei, the cytoplasm, and in telomeres and promoter sights. It can also be found in cell processes such as the G1 phase of the cell cycle.

Need more detail-- what are C-SWNT? Needs more information overall. Applications -- LRC

Due to the structural and functional components of the i-motif structure, many applications have been investigated, including cancer therapy and theranostics. Because i-motif can play a role in the regulation and detection of specific ligand binding, this could be used in regulating the vascular epithelial growth factor (VEGF).In a study by Takahashi et al., it was found that by using C-SWNTs, telomerase activity could be inhibited, which could potentially lead to apoptosis of cancer cells. — Preceding unsigned comment added by DrMZF (talk • contribs) 21:34, 11 December 2020 (UTC)