User talk:MakesNotSense

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– the WikiProject Medicine team Doc James  (talk · contribs · email) 22:38, 30 June 2019 (UTC)

What does this have to do with trazodone?
Insomnia has been association with sleep-related disordered breathing.

Doc James (talk · contribs · email) 22:44, 30 June 2019 (UTC)
 * The full text of this https://journal.chestnet.org/article/S0012-3692(10)60302-9/fulltext does not mention trazadone. Refs should generally at least mention the topic they are about. Doc James  (talk · contribs · email) 00:59, 1 July 2019 (UTC)

To: Doc James

Why does it matter if these sources do not directly mention trazodone?

The paragraph I wrote was added to Trazodon'e section on insomnia to illustrate that a significant portion of those with chronic insomnia have disordered breathing as a causative factor for their insomnia. That first sentence then ties into the second, and third, and so on, to illustrate the interactions observed in individuals with insomnia being treated with trazodone. A lot of the 'side effects' in sleep medications are symptoms found in patients with disordered breathing and observed to resolve when the disordered breathing is treated. The psychiatric fields negligence in attending to the role non-hypoxic respiratory events has upon sleep fragmentation and alterations in sleep architecture has lead to a paucity of research directly evaluating the impact psychoactive medications have on sleep quality.

I am not sure why you are taking one sentence out of context like this. Nor of what benefit such behavior is to the integrity of the information on wikipedia. Here is the full paragraph:

Insomnia has a known association with sleep-related disordered breathing. . "In our clinical practice and research experience, approximately 80% of patients reporting insomnia for >6 months also have SDB." Autonomic dysfunction has been observed to occur in individuals with sleep-related disordered breathing: "Our data demonstrate, for the first time, that some subjects with UARS have low resting arterial BP, OI, and orthostatic hypotension (OH)." Orthostatic hypotension is a known side effect of Trazodone. "Falling down as a result of fainting (syncope) is a common complication in people with orthostatic hypotension." . Clinical findings show syncope can respond favorably to the treatment of sleep-related disordered breathing. .

While I could understand criticism of the above paragraph you also erased this section:

Studies in animal models indicate trazodone can "impair sleep-dependent brain plasticity". .]

It directly studies trazodone and one of it's negative impacts to sleep. Sleep issues being one of Trazodone's primary off-label uses, it is directly relevant. Many of the most important studies in sleep science are animal studies because doing them in humans would be unethical. A good example is David Gozals study on cancer in rodents to determine the mechanisms by which sleep fragmentation causes cancer to become more prevalent and aggressive. Another good example is Harvold's Monkey experiments. A third example are the studies in rodents regarding the ability of ketosis to protect from hypoxia and improve oxygen efficiency. I'm not sure why you edited out everything. It honestly seems as if you take a cursory glance before taking action, and that is rather antithetical to engaging in a scientific process or relying upon an evidence-based paradigm. I am honestly curious what it is you're trying to accomplish.

MakesNotSense (talk) 17:01, 1 July 2019 (UTC)