User talk:Methyliodide/Epigenetics of Personality Disorders

	“…the epigenetic mechanisms behind personality disorders, such as BPD…” o	Spell out “Borderline Personality Disorder” the first time it is referenced in the article; this is currently done the second time it is referenced 	“Their literature search yielded no studies of epigenetics in regards to other common personality disorders, such as narcissistic, histrionic, anankastic, avoidant, paranoid, and schizoid personality disorder.” o	This sentence is a bit confusing. Try rewording the phrase “Their search yielded no…” This applies to the sentence that follows as well. 	For the first sentence of the second paragraph; what disorder are you referring to? This should be clearly stated in the first sentence of the paragraph. 	In paragraph two, make references to wiki articles for “promoter/exon,” “childhood maltreatment” (this will better define “childhood maltreatment” for the reader), and “Dialectical Behavior Therapy,” if possible. 	In paragraph three, make references to other wiki articles for “HPA axis,” “psychopathology,” “childhood abuse,” “Childhood Trauma Questionnaire.” 	For the final sentence in the second paragraph, what article/articles did this finding come from? Don’t forget to cite it/them. 	“Perroud et al. brought up an interesting point…” o	This is an opinion, thus should be removed.

Overall: There is a lot of good information here; however, it appears that some of it is missing citations (for example, the final paragraph only has one citation). There are quite a few grammar errors, it would be beneficial to carefully reread the article or have a group member read it aloud to someone else to aid in identifying these errors. There are many terms that could be linked to other wiki articles, as stated above. Agv2022 (talk)Agv2022

Gracelyn's Notes
I think that this article could use a bit more structure. The second paragraph, for example, heavily focuses on DNA methylation. As such, it could be useful to add a “DNA Methylation” heading in order to give the reader an easy and succinct visual cue indicating what they are about to read and whether or not the next body of text is pertinent to their interests. In the same regard, subheadings could provide even more clarifications— “BDNF” for the first half of the paragraph, “APBA3 and MCF2” for the second, and so on. As someone with trouble focusing, small details such as these allow me to orient my attention better.

There’s a lot of great mechanistic information here that builds a good foundation for understanding BPD through the lens of epigenetics; however, I think it’s important to really make sure each fact is adequately explained and related to the big picture at hand. Individuals with BPD exhibit higher DNA methylation, sure. But what does this mean for them? Is there research for treatments of BPD that deal with the epigenetic findings you have stated thus far? Connections such as these would be quite interesting.

Maintain a consistent voice throughout the article. Statements such as, “Perroud et al. brought up an interesting point…” does not fit well with the voice of the rest of the article and brings about a sense of informality, which in some cases is good, but in the case of a Wikipedia article, not necessarily.

Priya's Notes
First paragraph can be shortened to state more concisely that only methylation patterns and their deviations were found to be an important factor in relation to personality disorders and serve no inter-related function to childhood exposure or treatment. I am a little confused about what the second half of the sentence is stating. Is methylation unaffected by treatment and childhood experience?

In the second paragraph, you state that trauma is related to BPD but earlier information contradicts in terms of methylation and its role in BPD development. Breaking down this large paragraph by the exact gene and their relation/effect on methylation might make the larger idea easier to understand.

“Basically, it can be difficult to pinpoint which epigenetic alterations are associated with BPD alone.” I feel like this sentence might be better as the start to a paragraph as a clarification. Breaking down information into two sections of childhood trauma in relation to BPD and the role of treatments would make the information easier to follow.

How do gene variants tie into the development of BPD?

Going into details regarding NR3C1 and its role in epigenetics is something that might help with background information and understanding how its methylation can cause changes in the severity or development of BPD.

Aarzoo's Notes
This is a really great addition to this article. I agree that adding an epigenetics section to the original article would help bring in a different perspective to heighten the understanding behind personality disorders. I had a hard time grasping the overall message here in terms of epigenetics and personality disorders. I think that can maybe be stated a little more clearly so relevance and connections can be shown. I also agree with Trevor’s comments that there are alot of details here that can be zoomed out and tied to epigenetics and personality. It’s a matter of restructuring and sorting out the details too and then the article will be super solid.

The sources that yall are using are also credible and reliable sources. I would look into source 3 because it was published in 2009. We ran into some older articles in our wiki page and had to look into newer research to make sure it was still relevant.

Also would like to add, that some of the mentioned data and findings may not directly link to borderline personality disorders in a clear manner, but can be introduced as future areas of research to expand on. — Preceding unsigned comment added by Aarzoomaknojia (talk • contribs) 14:44, 5 April 2022 (UTC)