User talk:Nataliegierat/Trinucleotide repeat


 * JM: I like the information presented, but it can be expanded upon and possibly split into two different sections. You can have a section for structure and another one for mechanism.Nmbiochem (talk) 16:45, 10 December 2020 (UTC)Nmbiochem


 * JM: A heaading can be added, links to existing wikipedia pages (for Watson-Crick base pairing, for example), and citations. Nmbiochem (talk) 16:48, 10 December 2020 (UTC)Nmbiochem


 * JM: This is a minor edit, but usually numbers are written out. So in the first sentence, "3" should be "three".Nmbiochem (talk) 16:40, 10 December 2020 (UTC)Nmbiochem


 * JM: There's a typo in the second sentence. "rpeats" should be "repeats"Nmbiochem (talk) 16:41, 10 December 2020 (UTC)Nmbiochem


 * JM: The organization is a little confusing around sentences 3-5. You could possibly expand on sentence three. I'm not sure if sentence four is a transition into DNA slippage.Nmbiochem (talk) 16:50, 10 December 2020 (UTC)Nmbiochem


 * JM: Pictures or diagrams explaining misalignment with the template strand, hairpin structures (what are the stem and loop), and a tetraloop and triloop structures.Nmbiochem (talk) 16:55, 10 December 2020 (UTC)Nmbiochem


 * JM: More information on why the repeats being dynamic causes the length in an individual's tissues to be different could be helpful.Nmbiochem (talk) 16:59, 10 December 2020 (UTC)Nmbiochem


 * JM: Some information about what's to come in the rest of the article (even though you didn't write those sections) could be useful to the reader.Nmbiochem (talk) 17:01, 10 December 2020 (UTC)Nmbiochem


 * JM: Are the triplet repeats found in coding and non-coding regions different? If yes, then it would be good information to add.Nmbiochem (talk) 17:08, 10 December 2020 (UTC)Nmbiochem


 * JM: DNA slippage is talked about in sentence five and again in seven. Is there a way to bring those together?Nmbiochem (talk) 17:10, 10 December 2020 (UTC)Nmbiochem


 * JM: More information on the length in different tissues might be useful.Nmbiochem (talk) 17:11, 10 December 2020 (UTC)Nmbiochem

AC (Peer Review for Marcello): 1st Section:
 * In the first paragraph are you talking about the nervous system overall or is there a specific type of nervous system that you're explaining?


 * I believe the second sentence should be split into two-sentence to make it more cohesive.

2nd Section:
 * In the second paragraph I think substituting the word "desired" instead of "wanted" would sound a bit more scientific.


 * In the last sentence of the second paragraph, the semi-colon should come after the word "complex" instead of it being in front of the word "if".

3rd Section:


 * In the first paragraph you spelled nucleic incorrect. Also, I think that phrase sounds better like "15-20 nucleic acids in length".


 * You could split the second sentence of the second paragraph into two sentences due to it sounding like a run on sentence.


 * In the last sentence of the second paragraph, you should add a comma after "barrier".


 * In the third paragraph I think you should add a colon instead of a comma.

4th section:


 * In the first sentence, do you mean maximum or minimum? Just want to make sure, because I was under the impression that you meant maximum when explaining the threshold within the trinucleotide repeat expansion.

Citations:


 * Looks good!

Peer editor: Amey Duarte Username:Nataliegierat

Background of Fragile X syndrome (background) Biochem22S 17:27, 10 December 2020 (UTC)
 * Minor Suggestion: you might be able to link the wiki page to the FMR1 gene for more detailed information.

Genetic causation:
 * Good introduction sentence, I might just expand on what the Xq28.3 means and its significance. You could also link it to a wiki page.
 * This is a minor sentence structure suggestion for your sentence structure. It's already good, I just thought this would be a little more concise: "Research has shown that individuals with premutation alleles in the range of 59-69 repeats have about a 30% risk of developing full mutation compared to the 100% risk of those in the high range ≥ 90.
 * Minor suggestion: I might also add one more citation so your not paraphrasing just one source.
 * You have well-structured sentences and I have not spotted any grammar errors.

Promoter silencing:
 * I have a minor sentence edit, but what you have is grammatically correct. "The CGG trinucleotide expansion resides within the 5’ untranslated region of the mRNA, which undergoes hybridization to form a complementary CGG repeat portion. The binding of this genomic repeat to the mRNA results in silencing of the promoter. I would then briefly expand on promoter silencing and then link it to a wiki page.
 * Overall, this section is very interesting and informative. Your level of detail really stands out.

'''Huntington Disease (background)
 * Great introduction sentence!'''

HD (causation)
 * In this sentence you can possibly add This autosomal dominant disorder results from  the expansions of a trinucleotide repeat,  which involves the CAG in exon 1 of the IT15 gene.
 * Gametogenesis might need a wiki page reference in the second sentence of this section.
 * In the third sentence: You could make this sentence more cohesive by rearranging it and perhaps saying " While an individual without HD has a number of CAG repeats that fall between a range of 9 to 37, an individual with HD is found to have CAG repeats in a range between 37 to 102.
 * Great information on this 4th sentence in this section but it's a little long. I might break it up into two different sentences or replace and with another word so is not as repetitive. "Research has shown an inverse relationship between the number of trinucleotide repeats  and age of onset; however, no relationship between trinucleotide repeat numbers and rate of HD progression, individuals' body weight, and/or gender of the carrier parent  was observed.

Myotonic Dystrophy (background)
 * Great section! I only have a minor suggestion to think about. You could link Myotid Dystrophy to a wiki page.

Myotonic Dystrophy (Causation)
 * The second sentence is not very clear to me. I'm not sure what you meant to

Intergenerational Instability (Parental Influence)
 * Great and informative section

DNA Replication
 * I think you need a comma between model and suggestion in the 5th sentence "In addition to this possibility...."
 * Great ending, this information is very interesting