User talk:Nikolaivica

Hi Nikolai, you're on the right track but I think the article needs to be expanded a little more. How about implications on drug design? I.e. Transition state mimics that stabilize tetrahedral intermediate. You could mention the Weinreb-method to generate ketones, which relies on the formation of a stable tetrahedral adduct (btw most "normal" amides give ketones, too). And there's a method for ortho-lithiation of aromatic aldehydes using trimethyl-ethylene-diamine. See me if you have any questions.Christian.gampe (talk) 13:07, 24 October 2011 (UTC)