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Heart From Wikipedia, the free encyclopedia Jump to: navigation, search The heart and lungs, from an older edition of Gray's Anatomy.This article is about the organ. For other uses, see Heart (disambiguation). The heart is a muscular organ responsible for pumping blood through the blood vessels by repeated, rhythmic contractions, or a similar structure in the annelids, mollusks, and arthropods.[1] The term cardiac (as in cardiology) means "related to the heart" and comes from the Greek καρδία, kardia, for "heart." The heart is composed of cardiac muscle, an involuntary muscle tissue which is found only within this organ.[2] The average human heart beating at 72 BPM, will beat approximately 2.5 billion times during a lifetime of 66 years.

Contents [hide] 1 Early development 2 Structure 3 Functioning 4 First aid 5 Food use 6 Aztec heart removal 7 Hearts from cadavers beat 8 See also 9 References 10 External links

Early development Main article: Heart development At 21 days after conception, the human heart begins beating at 70 to 80 beats per minute and accelerates linearly for the first month of beating.It is unknown how blood in the embryo circulates for the first 21 days in the absence of a functioning heart, although some have hypothesized that the heart is not so much a pump, as a Hydraulic Ram -- an organ built-up from cumulative peripheral activity. [1]

When the human embryonic heart begins beating -- around 21 days after conception, or five weeks after the last normal menstrual period (LMP), which is the date normally used to date pregnancy. The human heart begins beating at a rate near the mother’s, about 75-80 beats per minute (BPM). The embryonic heart rate (EHR) then accelerates linearly for the first month of beating, peaking at 165-185 BPM during the early 7th week, (early 9th week after the LMP). This acceleration is approximately 3.3 BPM per day, or about 10 BPM every three days, an increase of 100 BPM in the first month.[3]

After peaking at about 9.2 weeks after the LMP, it decelerates to about 152 BPM (+/-25 BPM) during the 15th week after the LMP. After the 15th week the deceleration slows reaching an average rate of about 145 (+/-25 BPM) BPM at term. The regression formula which describes this acceleration before the embryo reaches 25 mm in crown-rump length or 9.2 LMP weeks is Age in days = EHR(0.3)+6

There is no difference in male and female heart rates before birth.[4]

Structure Anterior (frontal) view of the opened heart. Arrows indicate normal blood flow. Image provided courtesy of www.3dscience.com.In the human body, the heart is usually situated in the middle of the thorax with the largest part of the heart slightly offset to the left (although sometimes it is on the right, see dextrocardia), underneath the breastbone (see diagrams). The heart is usually felt to be on the left side because the left heart (left ventricle) is stronger (it pumps to all body parts). The left lung is smaller than the right lung because the heart occupies more of the left hemithorax. The heart is enclosed by a sac known as the pericardium and is surrounded by the lungs. The pericardium comprises two parts: the fibrous pericardium, made of dense fibrous connective tissue; and a double membrane structure containing a serous fluid to reduce friction during heart contractions (the serous pericardium). The mediastinum, a subdivision of the thoracic cavity, is the name of the heart cavity.

The apex is the blunt point situated in an inferior (pointing down and left) direction. A stethoscope can be placed directly over the apex so that the beats can be counted. It is located posterior to the 5th intercostal space in the left mid-clavicular line. In normal adults, the mass of the heart is 250-350 g (9-12 oz), or about three quarters the size of a clenched fist, but extremely diseased hearts can be up to 1000 g (2 lb) in mass due to hypertrophy. It consists of four chambers, the two upper atria (singular: atrium ) and the two lower ventricles. On the left is a picture of a fresh human heart which was removed from a 64-year-old male.

Functioning Human heartThe function of the right side of the heart (see right heart) is to collect de-oxygenated blood, in the right atrium, from the body and pump it, via the right ventricle, into the lungs (pulmonary circulation) so that carbon dioxide can be dropped off and oxygen picked up (gas exchange). This happens through the passive process of diffusion. The left side (see left heart) collects oxygenated blood from the lungs into the left atrium. From the left atrium the blood moves to the left ventricle which pumps it out to the body. On both sides, the lower ventricles are thicker and stronger than the upper atria. The muscle wall surrounding the left ventricle is thicker than the wall surrounding the right ventricle due to the higher force needed to pump the blood through the systemic circulation.

Starting in the right atrium, the blood flows through the tricuspid valve to the right ventricle. Here it is pumped out the pulmonary semilunar valve and travels through the pulmonary artery to the lungs. From there, blood flows back through the pulmonary vein to the left atrium. It then travels through the bicuspid valve to the left ventricle, from where it is pumped through the aortic semilunar valve to the aorta. The aorta forks, and the blood is divided between major arteries which supply the upper and lower body. The blood travels in the arteries to the smaller arterioles, then finally to the tiny capillaries which feed each cell. The (relatively) deoxygenated blood then travels to the venules, which coalesce into veins, then to the inferior and superior venae cavae and finally back to the right atrium where the process began.

The heart is effectively a syncytium, a meshwork of cardiac muscle cells interconnected by contiguous cytoplasmic bridges. This relates to electrical stimulation of one cell spreading to neighboring cells.

First aid HeartSee cardiac arrest for emergencies involving the heart

If a person is encountered in cardiac arrest (no heartbeat), cardiopulmonary resuscitation (CPR) should be started and help called. If an automated external defibrillator is available, this device may automatically administer defibrillation if this is indicated. Usually, if there is enough time, the person can be rushed to the hospital where he or she will be cared for by a cardiologist, a doctor who specializes in the heart and lungs.

Electrical innervation of the heart in health is supplied by two closely intertwined mechanisms. The first mechanism is well demonstrated in electrical coil systole (interpreted by the electrocardiogram as QRS)as an individualized myocardial electrical tree initiated by the sinoatrial node. Secondary diastolic electrical control is posited to represent autonomic recoil control from the vagus nerve and cardiac branches and the thoracic ganglia.

Food use The hearts of cattle, sheep, pigs, chickens and certain fowl are consumed in many countries. They are counted among offal, but being a muscle, the taste of heart is like regular meat. It resembles venison in structure and taste.

Aztec heart removal Main article: Human sacrifice in Aztec culture The Aztec civilization used the heart as a sacrificial token during the sacrifice of a human being. The priest used a stone knife to cut into the thoracic cavity and remove the heart, upon which it would be placed on a stone altar as an offering to the gods. The greatest sacrifice under the reign of Montezuma involved the removal of the hearts of over 12,000 enemy soldiers.[citation needed]

Hearts from cadavers beat In January, 2008, Doris Taylor, director, Center for Cardiovascular Repair, University of Minnesota used the core procedure of decellularisation to let hearts from animal cadavers beat by infusing live cells. The research used dead rats heart (stripped with detergents) and then new cells from baby rats are injected, and the dead heart beat after 8 days. Stem cells from humans can be removed from the recipient of the donated organ, thereby eliminating rejection by the immune system. The resultant transplanted bioartificial organ will benefit many heart patients.[5