User talk:Nsaunder/sandbox

Added to the types section with more about the structure of each endorphin. Deleted sentence about animals making morphine. Didn't see sentence as related

James' Peer Review 2/21

"They are produced by the central nervous system and the pituitary gland." - This sentence could be improved, and perhaps the basic function of endorphins in the body could be mentioned before their origin is mentioned.

"Types"

α-Endorphin- "The smallest endorphin being 16 amino acids long"


 * Change "Being" in this sentence


 * It may help to provide the molecular structures of the three different endorphins. Not everyone thinks in terms of amino acid sequences, and if you do provide the amino acid sequences, it would be helpful to link to the wiki pages of the respective amino acids.

"β-Endorphin- The longest of these fragments with 31 amino acids."


 * Fragments? Aren't they complete molecules? It may help to start each description of the alpha, beta, gamma molecules with the same short informative sentence. \

"These three types of endorphins are made through the fragmentation of precursor proteins. The original protein is called proopiomelanocortin (POMC). This protein is fragmented into smaller proteins including beta-lipotropin (β-LPH). β-LPH, a pituitary hormone with little opiate activity, is then continually fragmented into different peptides along with the different classes of endorphins. [3][4][5]"


 * Perhaps adding a "Synthesis" subheader to the article would help consolidate this information. You touched on the synthesis in the Introduction as well as in the Types subheader, but it may stand alone well.

History


 * This section may go well directly after the introduction and before the "Types" section.

Mechanism of Action


 * "The mechanism in the CNS is similar with difference." -Rephrase

"When the endorphin binds to the μ-receptor, it inhibits the release of the neurotransmitter gamma-aminobutyric acid (GABA) which increases the production and release of dopamine, the neurotransmitter associated with pleasure.[2][6]"


 * So the PNS uses endorphins to block pain signals through nerve transmissions, and the CNS uses endorphins to stimulate release of dopamine? It would be helpful to elaborate on the CNS mechanism of action, and more info on what endorphins are doing in the brain.

Properties

"With consistent exercise, the brain may down-regulate the production of endorphins in periods of rest and a person will need to continue to exercise in order to receive the same feeling.[9]"


 * The person will need to exercise more intensely..

--Jameschem (talk) 14:16, 21 February 2019 (UTC)

suggestions on article edits
It looks like you've replicated the information that is on the pages for the three types of endorphins. Two of those pages are close to blank, there is a ton of information on beta.

I like the mechanism of action section. It is a good idea to see if any of the words or phrases in that section can be linked to other wikipedia articles (CNS and PNS stick out). Lose "as discussed previously"... the sectioning of an article into headings is done so that someone does not have to read the entire article.--Drglheard (talk) 14:33, 21 February 2019 (UTC)