User talk:Peter morrell/Selection of studies

Here are some of the studies/clinical trials:- STUDIES OF THE ACTIVITY OF HOMEOPATHIC MEDICINES  KEY: BT = Biomedical Therapy   BM = Biologische Medizin   FKM = Forschung Komplementär Medizin 

wikified version of the table
I did it to show how it should be coded, instead of fusing html tags. It lacks font tags and cell size tags.

Reviews and meta-analyses...get your secondary sources, folks!
(copied from a recent homeopathy talkpage archive) There are 398 papers that fall under the "Reviews" tab at PubMed on the query "Homeopathy" (out of 3545 total papers). Below are a selection of interesting papers (that my institution can access) from the last couple of years, with money-quotes from abstract conclusions. I stopped after a couple dozen, travelling back to ~2002; this list isn't close to exhaustive, but it may prove useful for discussion & article building. Any responses should probably be made in a new section, or a subsection of this one, just for navigational clarity.


 * "There is currently little evidence for the efficacy of homeopathy for the treatment of ADHD."
 * "There is currently little evidence for the efficacy of homeopathy for the treatment of ADHD."


 * "...some homeopathically prepared remedies show promise for reducing infarct size and associated impairments...Individualized homeopathy may even play a helpful adjunctive role in treatment of sepsis. However, a great deal of systematic research effort lies ahead before most of the options discussed would meet mainstream medical standards for introduction into routine treatment regimens."
 * "...some homeopathically prepared remedies show promise for reducing infarct size and associated impairments...Individualized homeopathy may even play a helpful adjunctive role in treatment of sepsis. However, a great deal of systematic research effort lies ahead before most of the options discussed would meet mainstream medical standards for introduction into routine treatment regimens."


 * "...experiments with a high methodological standard could demonstrate an effect of high potencies. No positive result was stable enough to be reproduced by all investigators. A general adoption of succussed controls, randomization and blinding would strengthen the evidence of future experiments."
 * "...experiments with a high methodological standard could demonstrate an effect of high potencies. No positive result was stable enough to be reproduced by all investigators. A general adoption of succussed controls, randomization and blinding would strengthen the evidence of future experiments."


 * "The evidence from rigorous clinical trials of any type of therapeutic or preventive intervention testing homeopathy for childhood and adolescence ailments is not convincing enough for recommendations in any condition."
 * "The evidence from rigorous clinical trials of any type of therapeutic or preventive intervention testing homeopathy for childhood and adolescence ailments is not convincing enough for recommendations in any condition."


 * "The [studies] were generally of low methodological quality...Homeopathic medicines, tested in HPTs, appear safe. The central question of whether homeopathic medicines in high dilutions can provoke effects in healthy volunteers has not yet been definitively answered, because of methodological weaknesses of the reports..."
 * "The [studies] were generally of low methodological quality...Homeopathic medicines, tested in HPTs, appear safe. The central question of whether homeopathic medicines in high dilutions can provoke effects in healthy volunteers has not yet been definitively answered, because of methodological weaknesses of the reports..."


 * "The results suggest that, for several treatments, the risk-benefit profile is encouraging...For other therapies the evidence is weak or contradictory: homeopathy..."
 * "The results suggest that, for several treatments, the risk-benefit profile is encouraging...For other therapies the evidence is weak or contradictory: homeopathy..."


 * "Complex Homoeopathy...showed inconclusive results."
 * "Complex Homoeopathy...showed inconclusive results."


 * "effectiveness of homeopathy can be supported by clinical evidence and professional and adequate application be regarded as safe."
 * "effectiveness of homeopathy can be supported by clinical evidence and professional and adequate application be regarded as safe."


 * "On the basis of this review it is not possible to draw firm conclusions on the efficacy or effectiveness of homeopathy for anxiety."
 * "On the basis of this review it is not possible to draw firm conclusions on the efficacy or effectiveness of homeopathy for anxiety."


 * "Some positive results were described with homeopathy in good-quality trials in rhinitis, but a number of negative studies were also found. Therefore it is not possible to provide evidence-based recommendations for homeopathy in the treatment of allergic rhinitis, and further trials are needed."
 * "Some positive results were described with homeopathy in good-quality trials in rhinitis, but a number of negative studies were also found. Therefore it is not possible to provide evidence-based recommendations for homeopathy in the treatment of allergic rhinitis, and further trials are needed."


 * "Our analysis of published literature on homeopathy found insufficient evidence to support clinical efficacy of homeopathic therapy in cancer care."
 * "Our analysis of published literature on homeopathy found insufficient evidence to support clinical efficacy of homeopathic therapy in cancer care."


 * "There is [no] evidence for the pain-relieving efficacy of...homeopathy"
 * "There is [no] evidence for the pain-relieving efficacy of...homeopathy"


 * "the evidence for the effectiveness of homeopathy in depression is limited due to lack of clinical trials of high quality"
 * "the evidence for the effectiveness of homeopathy in depression is limited due to lack of clinical trials of high quality"


 * "The evidence related to...homeopathy...is not convincing enough to suggest effectiveness."
 * "The evidence related to...homeopathy...is not convincing enough to suggest effectiveness."


 * "Current evidence does not support a preventative effect of Oscillococcinum-like homeopathic medicines in influenza and influenza-like syndromes."
 * "Current evidence does not support a preventative effect of Oscillococcinum-like homeopathic medicines in influenza and influenza-like syndromes."


 * "There is not enough evidence to reliably assess the possible role of homeopathy in asthma."
 * "There is not enough evidence to reliably assess the possible role of homeopathy in asthma."


 * "There is insufficient evidence to recommend the use of homoeopathy as a method of induction."
 * "There is insufficient evidence to recommend the use of homoeopathy as a method of induction."


 * "To date, however, there is no convincing evidence for a therapeutic effect. There are only a few controlled trials, most of them with negative results. The few studies with positive results have not been reproduced."
 * "To date, however, there is no convincing evidence for a therapeutic effect. There are only a few controlled trials, most of them with negative results. The few studies with positive results have not been reproduced."


 * "homeopathic medicine may play a useful role as an adjunctive and/or alternative therapy."
 * "homeopathic medicine may play a useful role as an adjunctive and/or alternative therapy."


 * "Three independent systematic reviews of placebo-controlled trials on homeopathy reported that its effects seem to be more than placebo, and one review found its effects consistent with placebo. There is also evidence from randomized, controlled trials that homeopathy may be effective for the treatment of influenza, allergies, postoperative ileus, and childhood diarrhea. Evidence suggests that homeopathy is ineffective for migraine, delayed-onset muscle soreness, and influenza prevention. There is a lack of conclusive evidence on the effectiveness of homeopathy for most conditions."
 * "Three independent systematic reviews of placebo-controlled trials on homeopathy reported that its effects seem to be more than placebo, and one review found its effects consistent with placebo. There is also evidence from randomized, controlled trials that homeopathy may be effective for the treatment of influenza, allergies, postoperative ileus, and childhood diarrhea. Evidence suggests that homeopathy is ineffective for migraine, delayed-onset muscle soreness, and influenza prevention. There is a lack of conclusive evidence on the effectiveness of homeopathy for most conditions."


 * "It is concluded that the best clinical evidence for homeopathy available to date does not warrant positive recommendations for its use in clinical practice."
 * "It is concluded that the best clinical evidence for homeopathy available to date does not warrant positive recommendations for its use in clinical practice."


 * "Biases are present in placebo-controlled trials of both homoeopathy and conventional medicine. When account was taken for these biases in the analysis, there was weak evidence for a specific effect of homoeopathic remedies, but strong evidence for specific effects of conventional interventions. This finding is compatible with the notion that the clinical effects of homoeopathy are placebo effects."
 * "Biases are present in placebo-controlled trials of both homoeopathy and conventional medicine. When account was taken for these biases in the analysis, there was weak evidence for a specific effect of homoeopathic remedies, but strong evidence for specific effects of conventional interventions. This finding is compatible with the notion that the clinical effects of homoeopathy are placebo effects."

Regarding the physical details in homeopathy research:

is interesting in its hands-off analysis of the dispute within clinical medicine over the validity of homeopathy and its implications for pharmacists.

is interesting in its exploration of the costs of alternative medicines compared to standard care.

-- this review highlights alleged "publication bias" (though they also state within the text that the results could just as easily be explained by "submission bias"). It's a quick read, and worthy for putting some of the above studies in more context.

I'll leave the floor open (for now) for anyone to explore the use of these or other studies in the present article. &mdash; Scientizzle 22:48, 14 January 2008 (UTC)

More refs copied from the Naturopathic medicine talk page
lymphocytes by pico- and femtogram quantities of cytostatic agents". Arzneim. Forsch./Drug Res., 1988, 38: 273-275. GIRI meeting, Paris, 1989, 31-46. solutions of CaCO3 on the growth of oat coleoptiles". Berl. J. Res. Hom., 1991, 1 (4/5): 275-278. "Platelets/endothelial cells interactions in presence of acetylsalicylic acid at ultra low dose". Omeomed 92 (C. Bornoroni, ed.), 1993, Editrice Compositori, Bologna: 109-115. 1993, 82: 124-125. immunosuppressive effect of histamine dilutions on human basophil action: effect of cimetidine". Inflamm. Res., 1997, 46:S27-S28. Ubichinon-Injeel on an acellular system". BM, 1997, 3; 99-104. lymphocyte and phagocyte activity". BM, 1998, 1; 3-11. fürNeturheilverfahre, 2000; 41: 542-7. Peter morrell 08:32, 22 April 2008 (UTC)
 * Colas H., Aubin M., Picard P., Lebecq J.C.. "Inhibition of lymphoblast transformation test (LTT) in phytohaemagglutinin (PHA) with Phytolacca americana in homeopathic dilution". Ann. Homéopat. Fr., 1975, 6: 1-11.
 * Mansvelt J.D., van Amons E. "Inquiry into the limits of biological effects of chemical compounds in tissue culture. I. Low dose effects of mercury chloride". Z. Naturtorschung, 1975, 30: 643-649.
 * Poitevin B., Aubin M., Royer J.F. "The effects of Belladonna and Ferrum phosphoricum on the chemoluminescence of human poly-morphonuclear neutrophils". Ann. Homéop. Fr., 1983, 3: 5-12.,
 * Aubin M. "Effect of aconitum and veratrumon the isolated perfused heart of the common eel (Anguilla anguilla)". Comp. Biochem. Physiol., 1984, 776: 367-369.
 * Aubin M. "Elements of homeopathic pharmacology". Homéopathie Franç., 1984, 72:231-235
 * Wagner H., Jurcic K., Doenicke A., Rosenhuber E., Behrens N. "The effect of homeopathic preparations on the phagocyte activity of granulocytes. In vitro tests and double-blind controlled trials". Arzneim. Forsch./Drug Res., 1986, 36: 1424-1425.
 * Poitevin B., Aubin M., Benveniste J. "Approach to quantitative analysis of the effect of Apis mellifica on the degranulation of human basophils cultivated in vitro". Innov. Tech. Biol. Med., 1986, 7: 64-68.
 * Wagner H., Kreher B., Jurcic K. "In vitro stimulation of human granulocytes and
 * Davenas E., Beauvais F., Amara J., Robinson M., Miadonna A., Tedeschi A., Pomeranz B., Fortner P., Belon P., Sainte-Laudy J., Poitevin B., Benveniste J. "Human basophil degranulation triggered by very dilute antiserum against IgE". Nature, 1988, 333: 816-818.
 * Poitevin B., Davenas E., Benveniste J. "In vitro immunologicaldegranulation of human basophilsis modulated by lung histamine and Apis mellifica". Brit. J. Clin. Pharmacol., 1988, 25: 439-444.
 * Wagner H., Kreher B. "Cytotoxic agents as immunomodulators". Proceedings of the 3rd
 * Boiron J., Belon P. "Contributions of fundamental research in homeopathy". Berl. J. Res. Hom., 1990, 1: 34-35.
 * Bornoroni C. "Synergism of action between indoleacetic acid (IAA) and highly diluted
 * Boiron J., Abecassis J., Cotte J., Bernard A.M. "Study of the action of Hahnemannian dilutions of mercury chloride on the mitotic index in animal cell cultures.". Ann. Homéop.Fr., 1991, 23: 43-49.
 * Bellavite P., Chirumbolo S., Lippi G., Andrioli G., Bonazzi L., Ferro I. "Dual effects of formylpeptides on the adhesion of endotoxin-primed human neutrophils". Cell. Biochem. Funct., 1993, 11: 231-239
 * Chirumbolo S., Signorini A., Bianchi I., Lippi G., Bellavite P. "Effects of homeopathic preparations of organic acids and of minerals on the oxidative metabolism of human neutrophils". Br. Hom. J., 1993, 82: 227-244.
 * Doutremepuich C., Lalanne M.C., Ramboer I., Sertillanges M.N., De Seze O.
 * Fougeray S., Moubry K., Vallot N., Bastide M. "Effect of high dilutions of epidermal growth factor (EGF) on in vitro proliferation of keratinocyte and fibroblast cell lines". Br. Hom. J.,
 * Enbergs H., Arndt G. "Effects of different homeopathic potencies of Lachesis on lymphocyte cultures obtained from rabbit blood". Biol. Tier., 1993, 4.
 * Gibson S.L., Gibson R.G. "The effect of homeopathic potencies of house dust mite on the migration of house-dust sensitive human leukocytes". Complement. Ther. Med., 1996, 4: 169-171.
 * Kanui T.I., Enbergs H. "The effects of Nux vomica, Homaccord and Atropinum comp. on intestinal activity in vitro". Biol. Tier., 1996/1, 43-47
 * Sainte-Laudy J., Belon P. "Application of flow cytometry to the analysis of the
 * Chirumbolo S., Conforti A., Lussignoli S., Metelmann H. et Al. "Effects of Podophyllum peltatum compounds in various preparations and dilutions on human neutrophil functions in vitro". Br. Hom. J., 1997; 86-16.
 * Harisch G., Dittmann J. "In vivo and in vitro studies on the efficiency of potentized and nonpotentized substances". BT, 1997, 2; 40-46.
 * Harisch G., Dittmann J. "Experiments with the effects of Ubichinon-Injeel and strong
 * Enbergs H. "Efficacy of the homeopathic drugs Suis and Arnica comp.-Heel® on
 * Harisch G., Dittmann J. "Influence of dilutions and potencies of cAMP on different enzymatic systems". BM, 1998, 2; 55-62.
 * Harisch G., Dittmann J. "Studies of the principles of homeopathy; the change over from in vivo to in vitro experimental research". BM, 1998, 2; 55-62.
 * Harisch G., Dittmann J. "Determination of the activity of acid phosphatase with cAMP at various potencies". BM, 1999, 1; 4-8.
 * Gomez J.C. "Contribution to study of the efficacy of homeopathic potencies of phosphorus". BT, 1999, 2; 53-57.
 * Harisch G., Dittmann J. "Determination of the activity of acid phosphatase in the presence of Ubichinon comp.". BM, 1999, 4; 188-194.
 * Dittmann J., Kanapin H., Harisch G. "Biochemical efficacy of homeopathic and electronic preparations of D8 potassium cyanate". FKM, 1999, 6; 15-18.
 * Palermo C., Filanti C., Poggi S., Manduca P. "Osteoporosis in vitro in rat tibia derived osteoblasts is promoted by the homeopathic preparation, FMS Calciumfluor". Cell Biol Int, 1999, 23(1): 31-40.
 * Schmolz M. "Thin-layer chromatography (TLC)of homeopathic active constituents". BM, 1999, 5; 248-250.
 * Datta S., Mallick P., Khuda Bukhsh A.R. "Efficacy of a potentised homeopathic drug in reducing cytotoxic effects produced by arsenic trioxide in mice". Complement Ther Med, 1999Jan; 7 (8): 62-75 (a).
 * Datta S., Mallick P., Khuda Bukhsh A.R. Efficacy of a potentised homeopathic drug in reducing cytotoxic effects produced by arsenic trioxide in mice". Complement Ther Med, 1999 Sep; 7 (3): 156-63 (b).
 * Heine H. "Non-cytotoxic antiviral action of a homeopathic drug". Ärzteitschrift
 * Kundu S.N., Mitra K., Khuda Bukhsh A.R. "Efficacy of a potentised homeopathic drug in reducing cytotoxic effects produced by arsenic trioxide in mice". Complement Ther Med, 2000 Sep; 1 (3): 157-65.
 * Crocnan D., Greabu M., Olinescu R. "Stimulatory effect of some plant extracts used in homeopathy on the phagocytosis induced chemiluminescence of polymorphonuclear leukocytes". Rocz Akad Med Biochemist, 2000; 45: 246-254.
 * Dittmann J., Harisch G. "Difference between the efficacy of single potencies and chords". BM, 2000, 1; 18-23.
 * Dittmann J., Kanapin H., Harisch G. "Influence of some homeopathic drugs on the catalytic activity of uricase, acid phosphatase and thecytosol glutathion-S-transferase". BM, 2000, 3; 125-131
 * Dittmann J., Kanapin H., Harisch G. "Influence of some homeopathic drugs on the catalytic activity of cAMP-dependent protein kinases". BM, 2000, 6; 289-296.
 * Jonas W., Lin Y., Zortella F. "Neuroprotection from glutamatetoxicity with ultra-low dose glutamate". Neuroreport, 2001 Feb 92; 12 (2): 335-9.

This page contains content from a banned user
This table was provided by a banned user. See:. -- Fyslee / talk 04:12, 24 March 2008 (UTC)
 * True. Are the sources unreliable? If so, it would be very cool to have some kind of explanation as to why. -GTBacchus(talk) 10:26, 24 March 2008 (UTC)

I attempted to pull together reliable secondary sources a few months ago: here's the archive of it...nobody responded to my work. Everything I list there is a review or meta-analysis. Perhaps this will help in the utility of this page--it's certainly less one-sided than the presentation from our banned Doc Jhingaadey. &mdash; Scientizzle 15:11, 1 April 2008 (UTC)


 * This section is no longer relevant. -- Fyslee / talk 05:51, 11 April 2008 (UTC)