User talk:Pgcudahy/Archive 1

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This block of text was unreferenced: "These "cocktails" consisting of at least three medications belonging to at least two types, or "classes" of antiretrovirals are able to suppress HIV in the blood to undetectable levels for long periods of time. Since then additional classes of antiretrovirals have been developed including CCR5 inhibitors, fusion inhibitors, and integrase inhibitors, most with multiple medications per class.

Choosing what therapy to use is based on whether a patient has been exposed to antiretrovirals in the past and is "treatment experienced" or has not been on medications and is "treatment naive." This is because previous treatment may have led to mutations in the HIV virus that can lead to drug resistance. Guidelines recommend that someone starting treatment for the first time usually be started on a combination of two NRTIs (referred to as the "backbone") and one medication from either the non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), or integrase inhibitors (referred to as the "base"). First line regimens recommended by the US Department of Health and Human Services are


 * efavirenz/tenofovir/emtricitabine (EFV/TDF/FTC)
 * ritonavir-boosted atazanavir + tenofovir/emtricitabine (ATV/r + TDF/FTC)
 * ritonavir-boosted darunavir + tenofovir/emtricitabine (DRV/r + TDF/FTC)
 * raltegravir + tenofovir/emtricitabine (RAL + TDF/FTC)

Treatment of patients who have been exposed to antiretroviral drugs before is guided by a viral genotype which can help to predict what drugs may be effective against the patient's strain of HIV. The same principle of trying to find three active drugs from at least two different classes is used."

Also please have a read of WP:MEDMOS to learn about our manual of style.

This text "Antiviral therapy for HIV started with the FDA approval in 1987 of the nucleoside analogue reverse transcriptase inhibitor (NRTI) zidovudine (AZT). Further NRTIs were developed in the subsequent ten years, but it wasn't until the introduction of the first protease inhibitor in 1995 that multiple drugs from different classes could be combined to form Highly Active Antiretroviral Therapy (HAART). " belong in the HAART article under history rather than in the HIV/AIDS article under treatment.

Additionally you have removed a Cochrane review and replaced it with an older primary source. Unsure why. Best Doc James  (talk · contribs · email) (if I write on your page reply on mine) 08:47, 3 January 2014 (UTC)

Changes
You mention that the initial paragraph is 7 years out of date. Yet it is based on the WHO 2010 guidelines. Agree that the 2013 guidelines are newer.

Recommendations in 2013 are still 3 agents (1 NNRTI and 2 NRTIs). The ones recommended not having changed. I have updated the refs to the 2013 WHO. Doc James (talk · contribs · email) (if I write on your page reply on mine) 08:56, 3 January 2014 (UTC)
 * Have updated the DHHS ref. There recommendations have not changed from 2009 but agree that the newer ref is better and actually the URL has not changed either. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 09:03, 3 January 2014 (UTC)

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Again, welcome! WhatamIdoing (talk) 18:55, 20 March 2014 (UTC)