User talk:Posassium/sandbox

=Peer Review=

Major Points
I was going to suggest linking to the microgliosis article to help readers outside of your field understand what it is, but I learned that that article does not exist. It might help to explain briefly what microgliosis is then. While I know what it is, other non-experts in the field might wonder why the sentence in which it is mentioned is relevant. You might still be in the process of adding information to your sandbox, but is schizophrenia the only disorder affected by/involving microglia? If not, it would be great if you could include other disorders that are, though you may already have planned to do so. I know your literature review focused on schizophrenia and microglia, but I can't remember exactly what you said your plans were for this article. A context memo on the sandbox's talk page might have helped. Are there specific "excessive inflammatory conditions" that the release of pro-inflammatory cytokines contributes to? It might help to be more precise and explicit (one of the requirements for an article to be considered "well written"). What are SNPs? (Single nucleotide polymorphism?) It would be helpful if the abbreviation was defined/spelled out.

Minor Points
I know you have the pictures from the microglia article currently on your sandbox, but would it be possible to also add relevant pictures to the part of the article you're working on? I'm not sure what kind of pictures relating to microglia's role in psychosis could exist though. Overall, what you have so far looks like a good start. I don't really have much else to say as far as minor points go, but hopefully I will have more suggestions for you after the next peer review.Hillaryjd (talk) 14:02, 27 March 2016 (UTC)

Hi Posassium,

Bellow is my review!

Major Points:The article begins with a good restructure of the first two paragraphs in the actual Microglia article. In the second paragraph there is mention of the BBB. Because the BBB is such an important part of this paragraph regarding the inflammatory response of the microglia, it may be useful to add a picture or diagram of the endothelial cells that make up the BBB. It may also be useful if the article mentioned a common type of pathogen that the microglia is sensitive too (bacteria? virus? injury?). In the first paragraph under Schizophrenia the article mentions "immune stressors," an example of a immune stressor could make this sentence stronger and provide more encyclopedic information on what exactly can cause microglia to become overactive and contribute to the development of Schizophrenia. The use of SNPs at the end of this paragraph may throw someone off who has forgotten what they learned in their genetics course. It would be helpful if the full name of "single-nucleotide polymorphism" were used before the abbreviation and linked to its' own wiki article page.

Minor Points: In the first paragraph under the heading "Role in psychosis" it might be helpful to readers who are not familiar with cytokines if a link is set up between "cytokines" and its wiki article. The article is free of any spelling or grammatical mistakes.

Looking forward to reading this article again and seeing what has been added and changed! Gandalf122 (talk) 20:51, 27 March 2016 (UTC)

Peer Review 2
Major Points In the second paragraph under the Microlglia heading, there is mention of microglia having several forms. A description of these different forms would be beneficial to this paragraph. The last sentence under the intro heading is missing a citation. In the last paragraph under microglia, (and other places), the editor says that microglia have the ability to "swallow" foreign bodies. It may be better to use a word like consume or incorporate the term phagocytosis. Under the Ramified section, the editor makes note of microglia being in specific locations throughout the brain, would it be better to mention these specific locations or to remove the word specific and just include "commonly found throughout the entire brain and spinal cord." Maybe this is just a difference in style, but if the word specific is used it may be better to point to the exact specifics it is in regards to. A link to the Wiki article for the term plasticity would be beneficial. A link to microgliosis in the schizophrenia section would be helpful as well.

Minor Points The article is free of spelling and grammar issues for the most part. A link was used to connect antigen-presenting cells in the Activated section but not the Amoeboid section. Since Amoeboid comes first in the article, it would make sense if it was linked earlier in the Activated section or in both sections. Gandalf122 (talk) 16:28, 3 April 2016 (UTC)

Peer Review #2
Major Points: What several forms can microglia adopt? It might be helpful to include this information for clarity purposes. With all the information in the original article combined you’re your edits, I’m sure all aspects of the subject (microglia) are covered, but it wouldn’t hurt to go back and check that all relevant aspects are discussed in the edited article (if not already in the original). How do microglia directly interact with pathogens and neurons? It would be helpful to expand on this information to make it more understandable and explicit. Minor Points: Other than a few minor spelling/grammar errors, the edits for the article appear to be up to the standard writing conventions Wikipedia expects its articles to adhere to. Longevity is misspelled in the info box. With the line “… ramified microglia are unable to phagocytose cells” – would using the more common term of phagocytize be a better choice? I’m not exactly sure why BBB is bolded, but it shouldn’t be as it is not part of the subheading and is instead included in the text. Hillaryjd (talk) 15:45, 3 April 2016 (UTC)