User talk:Prikale/Epigenetics of anxiety and stress–related disorders

Yvianna's Notes: There can be more added to the concept of fear conditioning, foremost a link to the wiki page for extinction (psychology) seems like a good start, that way the reader can understand the concept a little more --> https://en.wikipedia.org/wiki/Extinction_(psychology) I found an article that goes more in depth in the relationship for fear extinction and PTSD titled: Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation the article highlights the major role of fear conditioning in PTSD, it can then be explained with a more epigenetic background based on this article:Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder this article explores the epigenetic mechanisms in which the traumatic experience memories are formed, stored, updated and terminated. Additionally there is mention of Fear memory as a model for PTSD, this would go great with the section about research models, there is an image that explains the concept really well in Figure 1 of the article. The following is directly from the article: "For fear memory, this means that epigenetic changes may drive the persistent behaviors associated with PTSD, including re-experiencing the event, avoiding cues that trigger memories of the trauma, and continuous hyperarousal [4]. Here, we review the evidence that epigenetic mechanisms are involved in acquiring, storing, updating, and extinguishing fear memory."Overall I like the general organization of the edits, but there is space for a couple more detailed explanations of concepts.

Yviannna (talk) 02:42, 4 April 2022 (UTC)

Courtney's Notes: The introductory section, ‘hypothalamus-pituitary-adrenal axis’ section, and ‘Research Models Used to Study PTSD Medication’ sections seem thoroughly researched and organized; however they are devoid of in-text citations unlike other edits in this article. It might be beneficial to include citations providing evidence for implicit information like “as cortisol plays a key role in stress response” since a major component of this article concerns cortisol pathways. In the section labeled ‘Propranolol’ you might want to include cited information from more than one source for the sake of credibility and to increase the strength behind presented information. The intent behind formatting the subsection under the section ‘Propranolol’ was unclear. I’m not sure if you intended for this information to apply to all of the other ‘Potential epigenetic drug treatments’ or simply propranolol. If this information applies to all other drug treatments being presented, you might want to move this section to the end of the list and change the heading format to be consistent. Additionally, is this information significant enough to have its own heading or could you integrate the information into the previous sections? If you intended this to be a subheading for propranolol, you might want to consider the organizational pattern of other sections and include information/citations more specific to the drug treatment. Since the other sections about ‘Potential epigenetic drug treatments’ do not include subsections like this, it might be something to consider in regard to continuity of formatting throughout the article. Overall, great work!