User talk:Roadnottaken

Unspecified source for Image:Pharmacia deluxe.jpg
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Welcome to the Wikipedia
Welcome, !

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This month's winner is RNA interference!
– ClockworkSoul 14:39, 2 December 2006 (UTC)

This month's MCB Collaboration of the Month article is Peripheral membrane protein!
– ClockworkSoul 18:59, 14 January 2007 (UTC)

Lipid Signaling
You added some good new material to Lipid signaling but also blanked out a bunch of fair material. Was this by accident? By the way, your edits there are not minor. David.Throop 04:01, 20 February 2007 (UTC)
 * no it was not by accident, but i did not get a chance to finish the edit (is there a way to save a draft?). i'm taking most of the DAG/IP3 stuff out as it is thoroughly covered elsewhere and, personally, i think intercellular signaling molecules with dedicated GPCRs fit the definition of lipid signaling better.  do you agree? Roadnottaken 15:09, 20 February 2007 (UTC)

Lipd signals and endocannibinoids
When I'm doing a major rework of a page, I create a sandbox. Then I can save every 100 keystrokes or so and not worry about cluttering up the history page of the article.

I restored the material you'd removed. If you think that something is better covered elsewhere, move it to the Talk: page. That gives the author a chance to weigh in. Even if it's better covered elsewhere, you should leave a couple of sentences as a summary, with a See detail at... linkage.

If you are removing more than a few keystrokes of somebody else's work, it is not a Minor Edit. Don't check the 'Minor Edit' box.

I'm still not clear just how the term 'lipid signalling' is used in the field, so I don't have an informed opinion about DAG/IP3.

Great to have an endocannibinoid resource around! Maybe you can explain something to me. In the eicosanoids, the biggest news of the last 20 years is that omega-3 EPA leads to families of eicosanoids that mitigate the activities (particularly the inflammatory activity) of the Arachidonic Acid derived eicosanoids. There's a tremendous amount of interest in the differential effect the AA-derived vs the EPA-derived eicosanoids. This interest extends out into the popular press.

In the endocannibinoids, EPA (and DHA?) form anandimide analogues. Do they modulate anandimide signaling in a way similar to the way the EPA-derivatives modulate the COX and 5-LO pathways? When I eat salmon, am I shaking up my CB1 / CB2 pathways? I've gone hunting for research articles on this and I'm find almost nothing. I'd think that this would be one of the most urgent questions in endocannibinoid research. Am I missing something? David.Throop 20:47, 20 February 2007 (UTC)


 * Oh, btw, thanks for the cool picture for lipid signalling. —The preceding unsigned comment was added by David.Throop (talk • contribs) 20:50, 20 February 2007 (UTC).
 * N-docosahexaenoyl ethanolamide is present in mouse-brain (at levels similar to anandamide) and i imagine any fatty acids from your diet would eventually work their way in to N-acylethanolamines at some concentration. that being said they are almost certainly less potent agonists of CB receptors than AEA.  additionally, the biosynthetic pathways for AEA have not yet been thoroughly worked-out so the REGULATED production of these signaling lipids may turn out to be specific for AA.  maybe not.  in any event, you need to elevate the concentration of AEA quite a bit (by inhibiting FAAH) before you start seeing overt behavioral effects in mice (altho there are probably subtle phenotypes that we can't see in mice)...  anyway my opinion is that all PUFA NAE derivates activate CB receptors at some level and that your diet probably does affect the distribution of PUFAs available for conversion to NAEs, but that the biosynthesis and degradation are probably tightly regulated such that you can't screw-up endocannabinoid signaling by changing your diet.  i'll try to find some references supporting this view, but it's pretty unsubstantiated.  to really do the experiment you'd have to feed animals high levels of 13C labled PUFAs which are very expensive.  Roadnottaken 16:28, 21 February 2007 (UTC)

Visual Signaling
Sounds good – go ahead and create the article. I encourage you to build the article in your sandbox until you've got it up to 'first release' standard. Be bold.

But do make a thorough search first. I've started several articles only to realize later that I'd duplicated something already extant. Trick is to use the Search box on several cominations of likely keywords, and use the 'What links here' on some related articles. David.Throop 05:33, 23 February 2007 (UTC)

License tagging for Image:DAGv1.png
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License tagging for Image:Phospholipases.png
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Myriocin
Hello. Please don't forget to provide an edit summary. Thanks, and happy editing.

Please remember to mark your edits as minor when (and only when) they genuinely are minor edits (see Minor edit). Marking a major change as a minor one (and vice versa) is considered poor etiquette. The rule of thumb is that only an edit that consists solely of spelling corrections, formatting and minor rearranging of text should be flagged as a 'minor edit'. Thanks! --Mel Etitis ( Talk ) 10:37, 20 March 2007 (UTC)

Good job
Good job with the Image:Signal_transduction_v1.png! (Looks much better than my version. Mortsggah 17:22, 7 April 2007 (UTC)
 * Thanks I think I accidentally deleted your version which is unfortunate since I copied yours exactly, only using Illustrator, and it would be nice to be able to reference it Thanks for the original! Roadnottaken 20:58, 7 April 2007 (UTC)

Very nice summary
Your Image:Signal_transduction_v1.png is really helpful for summarizing cell signalings. Do you mind sending me a copy in AI or PDF format? Thanks much! Gyaowiki (talk) 15:56, 21 December 2008 (UTC)
 * Hi Gyaowiki, I'm glad you like the figure. I should mention that before the current figure, there was a hand-drawn figure (here) that I basically copied exactly, using Illustrator.  So, I didn't make any conceptual contribution, only artistic.  That said, you're welcome to a vector version and you can download a PDF (made and editable in Illustrator) here:  [[file:signal_transduction_v2b.pdf]].  Let me know if you have any problems.   Roadnottaken (talk) 20:23, 21 December 2008 (UTC)

Image:Myelinated_neuron.png listed for deletion
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License tagging for Image:Common lipids.png
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65.40.217.147
I blocked him for a day (the usual for a first-time vandal outside of the school year, I think). But next time at least make a point of going through the full cycle of warnings on the associated user talk page. Daniel Case 18:11, 7 July 2007 (UTC)
 * ok thanks. i'm just starting to learn about vandalism procedures (beyond reverting) and i wonder why a user that's made nothing but disruptive contributions isn't treated more harshly?  i.e. it seems like a 24hr blockage isn't a big deal... what's the next step if there's more vandalism in the future?

your sugars are retarded! and fix the glycolipid page!!! thanks!!! :) — Preceding unsigned comment added by 137.131.130.223 (talk • contribs)

Thanks
Thank you for Myriocin

AbuAmir 11:47, 22 July 2007 (UTC)

Wikilinks added to Monoglyceride
Please remember to link to diglyceride instead of diacylglycerol. Sakkura 20:08, 30 July 2007 (UTC)
 * since you set up the redirect I can't see why it matters... but OK. Roadnottaken 20:20, 30 July 2007 (UTC)

Image:Gel-abpp eg.jpg
Hello, this is a message from an automated bot. A tag has been placed on Image:Gel-abpp eg.jpg, by another Wikipedia user, requesting that it be speedily deleted from Wikipedia. The tag claims that it should be speedily deleted because Image:Gel-abpp eg.jpg fits the criteria for speedy deletion for the following reason: dupe of Image:Gel-abpp_eg.png To contest the tagging and request that administrators wait before possibly deleting Image:Gel-abpp eg.jpg, please affix the template  to the page, and put a note on its talk page. If the article has already been deleted, see the advice and instructions at WP:WMD. Feel free to contact the bot operator if you have any questions about this or any problems with this bot, bearing in mind that this bot is only informing you of the nomination for speedy deletion; it does not perform any nominations or deletions itself. --Android Mouse Bot 2 01:53, 9 August 2007 (UTC)

WikiProject Pharmacology Collaboration of the Week
WikiProject Pharmacology is currently organizing a new Collaboration of the Week program, designed to bring drug and medication related articles up to featured status. We're currently soliciting nominations and/or voting on nominations for the first WP:RxCOTW, to begin on September 5, 2007. Please stop by the Pharmacology Collaboration of the Week page to participate! Thanks! Dr. Cash 17:54, 1 September 2007 (UTC)

Pharmacology Collaboration of the Week
Aspirin has been selected as this week's Pharmacology Collaboration of the Week! Please help us bring this article up to featured standards during the week. The goal is to nominate this at WP:FAC on September 10, 2007.

Also, please visitWP:RxCOTW to support other articles for the next COTW. Articles that have been nominated thus far include Doxorubicin, Paracetamol (in the lead with 4 support votes so far), Muscle relaxant, Ethanol, and Bufotenin.

In other news:


 * Bupropion has been promoted to featured status on August 31, 2007.


 * The WikiProject Pharmacology main page has been updated and overhauled, to make it easier to find things, as well as to highlight other goals and announcements for the project.


 * Garrondo is asking for individuals to help review Therapies for multiple sclerosis, as he is considering nominating this article for GA status.


 * Fvasconcellos notes that discussion is ongoing regarding the current wording of MEDMOS on including dosage information in drug articles. All input is welcome.

Dr. Cash 00:52, 5 September 2007 (UTC)

WikiProject Pharmacology Update
Here's a brief update in some of the recent developments of WikiProject Pharmacology!


 * Aspirin has just completed its two week run as the first Collaboration of the Week! Many thanks to those editors that contributed; the article got a lot of good work accomplished, and in particular, much work was done in fixing up the history section. It's still not quite "done" yet (is a wikipedia article really ever done?), but after two weeks I think it's more important to push onwards with the development of the new collaboration of the week program. I will be fixing up Aspirin in the next few days and possibly nominating it for either GA or FA status.


 * Muscle relaxant has been selected as the new Collaboration of the week until October 2, 2007! This article is currently rated as a "stub", so it's got quite a bit of work cut out for collaborators! Admittedly, featured status could be a long way off,... but still attainable! At the least, maybe we could at least get it up to meeting the Good article criteria? Please stop by the article and help improve it.


 * Resveratrol, having recently achieved GA status on August 16, 2007, is now making a run for featured status. This is quite a fascinating compound. If you can, please stop by its discussion page and leave comments in support of it.


 * Please remember that Wikipedia is not a forum for discussing or dispensing medical advice amongst users. Specifically, talk pages of articles should only be used to discuss improving the actual article in question. To help alleviate this situation, the template talkheader may be added to the top of talk pages, reminding users of the purpose of such pages. Additionally, unsigned comments and comments by anonymous users that are inappropriate may be removed from talk pages without being considered vandalism.


 * There was an interesting article on ZDNet last week about Hewlett Packard licensing its patented microneedle technology used in common inkjet printers to be used in transdermal patches to deliver a time-controlled release of drugs to patients. This information could be added to articles such as route of administration or drug delivery.

You are receiving this message because you are listed as one of the participants of WikiProject Pharmacology.

Dr. Cash 04:54, 19 September 2007 (UTC)

Review of edits
Hello. I recently looked at the 6-hydroxydopamine article and found that the chembox you added to the page in July 2007 was likely a cut'n'paste from another article. You did not however change any of the chemical values leading to some very incorrect information within the chembox on the article's page (SMILES, chemical formula, pubchem link, etc). I fixed the values on that article. I have not reviewed any other chemical pages you may have modified in that time frame but if you are aware of any other articles where you pasted a chembox in recent months, you may want to review your edits to determine if there are other pages with incorrect information. Thanks. ju66l3r 17:05, 18 October 2007 (UTC)
 * wow, sorry about that. thanks for catching it.  i'm usually much more careful than that.  i don't know what i was smoking that day.... Roadnottaken 18:39, 18 October 2007 (UTC)

Pepstatin A
Hello, I noticed that the chemdraw image in your Pepstatin A stub was incorrect in the leftmost valine.

Cheers,

Blindy3788 06:03, 20 October 2007 (UTC)
 * good catch, thank you. sorry for the mistake, it's fixed now.  Roadnottaken 15:44, 20 October 2007 (UTC)

Inositol synthesis
The numbering on your Inositol biosynthesis is backwards. —Preceding unsigned comment added by 137.131.236.80 (talk) 17:44, 29 October 2007 (UTC)

WikiProject Pharmacology Update
Here are a few updates in the realm of WikiProject Pharmacology:


 * The Pharmacology Collaboration of the Week has been changed to Collaboration of the Month, based on current participation levels. It is also more likely that articles collaborated on for one month are more likely to achieve featured quality than articles worked on for only a week or two.


 * The current Collaboration of the Month for November is Receptor antagonist. Please take a look at that article and contribute to it if you get a chance. Ideally, the article should adhere to the featured article criteria.


 * Therapies for multiple sclerosis is currently a featured article candidate. If you are familiar with the featured article criteria, please visit WP:FAC and review the article.


 * Anabolic steroid is the wikiproject's newest Featured Article, having been promoted on October 8, 2007.


 * Theobromine was delisted as a Good Article. The Peer review and GA reassessment discussions provide suggestions on improvement. Muscle relaxant was recently reviewed for Good Article status, but not promoted. Please see the full review full review here for details.

Dr. Cash 22:17, 31 October 2007 (UTC)

image trouble
There seems to be a problem with Image:Signal transduction pathways.jpg. When I try to view the image I get this message, "The image “http://upload.wikimedia.org/wikipedia/en/0/07/Signal_transduction_pathways.jpg” cannot be displayed, because it contains errors." --JWSchmidt (talk) 20:47, 3 January 2008 (UTC)
 * yeah I uploaded a fixed version (Image:Signal_transduction_v1.png) that should work fine. I think I couldn't figure out how to delete the broken one so i just left it there but there shouldn't be any references to it, no?  Roadnottaken (talk) 23:49, 3 January 2008 (UTC)

Signal Transduction Path Citation
I do a lot of path-related work and I really like your high level view of signal transduction. I am trying to figure out how to cite it it a manuscript and feel your name would be a lot better than saying "we found this image on Wikipedia, and we liked it"

Ideas?

Tombadog (talk) 20:57, 30 October 2008 (UTC)

The signal transduction path is really quite beautiful! doctorwolfie (talk) 19:31, 29 October 2009 (UTC)

RNA biology
Wiki articles should be like good reviews, they cite the literature and tell you everything important that has been published. Things like "X has an effect in vitro on Hela cells" is not all that important, so probably wouldn't make a review, so shouldn't be in a Wiki article. That's where I see notability trumping verifiability - it may be true, but since nobody cares we needn't tell everybody. Tim Vickers (talk) 01:42, 26 December 2008 (UTC)

Inositol biosynth.png
I just wanted to let you know that I have marked the image File:Inositol biosynth.png with disputed chem because it appears to show the wrong isomer of glucose. Please see the comment at Talk:Inositol. Do you think you can correct and replace the image? Thanks. -- Ed (Edgar181) 20:02, 9 January 2009 (UTC)

Protomap (neuroscience)
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Cannabinoids?
Hey! It's nice to see some other users who are knowledgeable about cannabinoids. I'm looking to recruit some other scientist to WPCannabis to add to the depth of cannbinoid-related content. I hope to see you there! --Kpstewart (talk) 07:54, 27 June 2009 (UTC)

Adding volcano plots to the template for statistics Template:Statistics
Dear RoadNotTaken:

Your article on volcano plots seems well-done, but I have never heard of these graphics, which seem similar in purpose to many kinds of effects-graphs. Is there any evidence that these plots are widely used or very important in statistics?

Regardless, please consider removing your volcano plots from the template of statistics, which contains only the most important articles in statistics. You are most welcome to discuss adding your article on the discussion page of the template, of course. If I do not see a response rather quickly, I may remove your change myself.

Thank you for your consideration. Sincerely, Kiefer.Wolfowitz (talk) 22:11, 3 January 2010 (UTC)

File:Inositol biosynth.png listed for deletion
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File source problem with File:Cravatt.jpg
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Speedy deletion nomination of File:Tilicho panoram.jpg
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If you think that this notice was placed here in error, you may contest the deletion by adding  to the top of the page that has been nominated for deletion (just below the existing speedy deletion or "db" tag - if no such tag exists then the page is no longer a speedy delete candidate and adding a hangon tag is unnecessary), coupled with adding a note on the talk page explaining your position, but be aware that once tagged for speedy deletion, if the page meets the criterion, it may be deleted without delay. Please do not remove the speedy deletion tag yourself, but don't hesitate to add information to the page that would render it more in conformance with Wikipedia's policies and guidelines. --ARTEST4ECHO talk 21:31, 28 September 2010 (UTC)

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Proposed Image Deletion
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The Wikipedia Library now offering accounts from Cochrane Collaboration (sign up!)
Cochrane Collaboration is an independent medical nonprofit organization consisting of over 28,000 volunteers in more than 100 countries. The collaboration was formed to organize medical scholarship in a systematic way in the interests of evidence-based research: the group conducts systematic reviews of randomized controlled trials of health-care interventions, which it then publishes in the Cochrane Library.

Cochrane has generously agreed to give free, full-access accounts to 100 medical editors. Individual access would otherwise cost between $300 and $800 per account. Thank you Cochrane!

If you are stil active as a medical editor, come and sign up :)

Cheers, Ocaasit &#124; c 19:57, 16 June 2013 (UTC)

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Nomination of Constance Simon for deletion
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Speedy deletion nomination of File:Signal transduction v2.pdf


A tag has been placed on File:Signal transduction v2.pdf requesting that it be speedily deleted from Wikipedia. This has been done under section F10 of the criteria for speedy deletion, because it is a file that is not an image, sound file or video clip (e.g. a Word document or PDF file) that has no encyclopedic use.

If you think this page should not be deleted for this reason, you may contest the nomination by visiting the page and clicking the button labelled "Contest this speedy deletion". This will give you the opportunity to explain why you believe the page should not be deleted. However, be aware that once a page is tagged for speedy deletion, it may be removed without delay. Please do not remove the speedy deletion tag from the page yourself, but do not hesitate to add information in line with Wikipedia's policies and guidelines. Pkbwcgs (talk) 11:22, 27 October 2017 (UTC)

Proposed deletion of File:Conniesimon.jpg


The file File:Conniesimon.jpg has been proposed for deletion&#32;because of the following concern: "unused, low-res, no obvious use"

While all constructive contributions to Wikipedia are appreciated, pages may be deleted for any of several reasons.

You may prevent the proposed deletion by removing the notice, but please explain why in your edit summary or on the file's talk page.

Please consider addressing the issues raised. Removing will stop the proposed deletion process, but other deletion processes exist. In particular, the speedy deletion process can result in deletion without discussion, and files for discussion allows discussion to reach consensus for deletion.

This bot DID NOT nominate any file(s) for deletion; please refer to the page history of each individual file for details. Thanks, FastilyBot (talk) 01:02, 1 February 2020 (UTC)