User talk:Rocksloth

Some missing information on Norbert Perrimon's page
It strikes me that Dr. Perrimon's page is out of date. For instance, there is no mention of how his lab pioneered high-throughput whole genome RNAi screening to interrogate systematically the function of all fly genes in various cell-based assays (Boutros et al. 2004). NOR is there mention of how he and Ram Viswanatha developed CRISPR/Cas9 pooled screens in Drosophila cells to facilitate large-scale screen in Drosophila and other arthropod cell lines (Viswanatha et al., 2018). This approach is particularly powerful to identify the mechanism of entry of toxins (Xu et al., 2022).

Dr. Perrimon has made fundamental discoveries on the components of by which cells communicate (Wnt, receptor tyrosine kinase and JAK/STAT). His group characterized in particular the  Raf kinase (Amrosio et al., 1989 ); the non-receptor tyrosine phosphatase Corkscrew/SHP2 (Perkins et al., 1992); the EGF ligand Spitz (Rutledge et al., 1992); Porcupine, Dishevelled and GSK3 as components of Wnt/Wg signaling (Kadowaki et al., 1996; Klingensmith et al.,. 1994; Siegfried et al., 1992); and Unpaired, Hopscotch/JAK and Marelle/STAT as members of the JAK/STAT pathway (Binari et al., 1994; Harrison et al., 1998; Hou et al., 1996). He also characterized the role of Heparan Sulfate Proteglycans in Hedgehog, Wnt and FGF signaling (Lin et al.,1999).

Perrimon played a substantial role in characterizing the structure and maintenance of epithelia, characterizing key proteins involved in cell polarity (Bilder et al., 2000). His group also discovered intestinal stem cells in the adult Drosophila midgut (Micchelli et al., 2006), a system that has emerged at the forefront of stem cell studies. Currently, Perrimon is studying the intricate interactions among organs and of the role that hormones play in coordinating the state of one organ/tissue with others under both normal and challenged conditions. He is particularly interested in how miscommunication between organs are associated with organ wasting/cachexia (Kwon et al., 2015).

I feel like these contributions to Drosophila studies should be noted on his page. Rocksloth (talk) 16:24, 7 September 2023 (UTC)