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I think about “APOPTOSIS INDUCTION BY GROWTH FACTOR INHIBITION IN OSTEOSARCOMA” Posted on December 19, 2010 by saead Osteosarcoma is an aggressive and highly metastatic neoplasm arising from primitive cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid. It is the most common primary bone cancer in human as well as animals. Since osteosarcoma usually develops from osteoblasts, despite other cancer type, it could be seen in young ages as well. Although it can affect any bone, however, most osteosarcomas appear in the long bones of the body, such as the femur, tibia, radius or humerus.

Osteosarcoma is the sixth leading primary bone neoplasm and most commonly found in adolescents and young individuals. About 60% of cases occur in entities in early maturation due to high osteoblastic activity in that period of age. There are no known risk factors for osteosarcoma, though young population might be at higher risk if meanwhile they suffer from Li-Fraumeni syndrome. Mature adults also may be at high risk if they have a history of Paget’s disease or radiation therapy used to treat other cancers.

Signs and symptoms of osteosarcoma may include Persistent pain, swelling or a firm lump on a bone, especially on an arm or leg, Pain or difficulty breathing (if the tumor affects the ribs) and high susceptibility to bone fracture that occurs spontaneously or after a minor bump. Definite diagnosis of osteosarcoma is made by direct biopsies of the affected site; however owing to its aggressiveness, radiography has become more popular among paraclinical diagnostic tools.

MRI provides tremendous information; though, its availability and costs made this mean a second diagnostic material.

By: Saeid Navid

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