User talk:Sipwine635

ALS [amyotrophic lateral sclerosis]
I have a young daughter who has ALS. I am also a retired physician so have some background in science. For the past several months I have been researching ALS on the internet. Wikipedia has been a very helpful sight for information on this disease. My concentration has been on sporadic Amyotrophic lateral sclerosis[SALS]. What I have learned so far is that mainstream neurologists are unable to treat this disease and do not know the cause. Let me start with what is partially known about the mechanism of this disease and then explain my rational for the treatments I have instituted. some statistics I have gleaned from wikipedia. Over 90% of SALS patients have an excess of glutamate, an excitoxic neurotransmitter. Only 4% of cases are due to gene mutation, in specific superoxide dismutase [SOD1]. Rightly or wrongly because of the above information my treatment focus has been on excitatory neurotransmitters therefore glutamate. The only product that has an opportunity of lowering glutamate is the antioxidant glutathione [GSH]. I would like to find a source for Glutamate dehydrogenase[GDH]which breaks down glutamate? The most prevalent Inhibitory neurotransmitter is gamma amino butyric ac. [GABA]. The medication Baclofen has been derived from GABA. It is present at sites not occupied by glutamate. Glycine is another natural occurring inhibitory neurotransmitter, a non essential amino acid, that can be synthesized from Serene. I do not know if the quantity of inhibitory neurotransmitters have an effect on the quantity of excitatory neurotransmitters? With the above information I have started my daughter on both GABA and Glycine her spasticity seems to be diminishing which I had hoped would occur because that is the purpose of Baclofen. My daughter has also been receiving mega doses of glutathione IV push twice weekly, when she can. I have been told that oral glutathione can not pass the GI mucosa but this is not true. There is a preparation, sustained release, that does pass the mucosa. I have placed my daughter on this preparation and intend to increase the doses of GABA, Glycine and Glutathione and monitor her response. I don't know whether the above passes the threshold for a scientific paper but I would hope it is allowed through so I can enlist individuals more knowledgeable than myself in attempting to find a method of curtailing this dreadful disease. All comments will be appreciated.