User talk:Timothy.li2021/sandbox

Here's a link to my sandbox page: https://en.wikipedia.org/wiki/User:Timothy.li2021/sandbox

Currently, it contains a very rough draft. Our plan is to add content under the following topics related to intrinsic termination based on research articles: function, structure, mechanism, inhibition, archaea bacteria vs eubacteria

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MLibrarian Review
It seems that your draft is unfinished. It would benefit from formatting and the content. References shall be provided in the reference section. Concepts hyperlinked. In the structure section, you repeat several times that the loop is not necessary. Perhaps, one time is enough. Would be great to have a picture for mechanism....MLibrarian (talk) 18:50, 15 October 2020 (UTC)

Intrinsic Termination Peer Review 1
I think it would be valuable to the reader to first address what Intrinsic Termination is before going into the the specific functions. Is it a technique? Biological pathway? Adding hyperlinks for ternary elongation complex (TEX) as well as other terms such as rho-independent/dependent termination could help with reader comprehension for those who are not as versed in scientific vernacular. The function section seems like it needs some work in terms of incomplete sentences and transitions between sentences. A figure or two could really help visualizing the mechanism and structure. Formatting the page to have appropriate indents and borders could also make it easier for the reader to keep track of ideas.

I completely understand this is merely a rough draft and I hope that these suggestions might help moving forward!

SultanElhaj (talk) 17:53, 14 October 2020 (UTC)

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Intrinsic Termination Peer Review 2
I think it would be a very good idea to add figures to this piece to accompany the great descriptions you provided. Finding a flowchart or step-by-step figure outlining the termination process would be ideal.

Be sure to use the Headings function (“==Heading Text==”) to make your Structure, Function, Mechanism, etc. headings appear distinct from the rest of the text.

Embed links to other Wikipedia pages for some terms mentioned like “Rho protein,” “RNA Polymerase,” and “Stem-loop.”

Adding an opening paragraph to the page could be very helpful to introduce the topic of intrinsic termination before diving into Function.

Build more of a connective flow between the sentences of the first paragraph for Structure; each one of them references information from a different source, so try to unify them with your own voice as you connect one point to the next.

When referring to a concept introduced in a previous sentence with only the word “this,” separate the two clauses with a semicolon rather than a period.

The work you have done is great so far and hopefully my suggestions offer some help! Once you make some minor refinements and toss in the “Inhibition” and “In Prokaryotes: Archaebacteria vs Eubacteria” sections, this will be a very strong page.

Mavs123 (talk) 00:14, 15 October 2020 (UTC)

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Intrinsic Termination Peer Review 3
First off, this looks like a great paper so far! I understand it is a super rough draft, but the topic is very interesting and this paper has a lot of great potential!

I agree with many of the points made by my fellow peer reviewers. So, also keeping their suggestions in mind, I had a few I thought would offer some help as well.

I took a look at the current version of the article. Will your group use the same lead/introduction found on there now? If so, I would recommend breaking down or simplifying that paragraph to reflect only the most important and key information of your paper.

As for the sections in your article, I would maybe include the "Mechanism" section underneath the overall "Function" heading, possibly as a subheading. These two tend two things tend to involve the same information and kind of flow after one another. In addition, I would consider putting the "Structure" tab as one of the first paragraphs in the paper; it is always helpful to understand the structure of something before trying to understand how it functions, so this setup maybe more effective for your readers.

There a couple of grammatical and typographical errors spread across the paper- be sure to go through and review spelling and sentence structure when you get closer to the final draft.

I noticed a lot of numbering/bullet pointing throughout your paper. Rather than including them in the paragraph, I would try putting a space or line in between individual numbers/bullet points. This would also make it easier to follow along with the ideas you are describing.

Finally, adding some figures and pictures will definitely bring your article to life! Also, linking other related Wikipedia pages to your article for your readers to talk a look at will tie it all in. Again, overall this is a great start to your paper! I look forward to seeing your final result!

Schamdin (talk) 02:47, 15 October 2020 (UTC)

Intrinsic Termination Peer Review 4
I understand that this is a rough draft, but make sure to go back and revise the Function section when re-editing this draft. Expand on the points that were bulleted.

Try to connect the sentences in the Structure section better so that they can flow nicely. In the first paragraph in particular, it seems as though a lot of information is thrown at the reader, and the majority of the sentences start with "The..." and are disconnected from one another.

Additionally, in the Structure section, there is a lot of information about intrinsic termination that is completely unrelated to the structure, such as info. about experiments that prove what is and isn't required. For organization's sake, I would recomment either moving this information elsewhere, or revisiting the heading name.

Looking at the original wikipedia page, I found their little graphic to be very helpful in visualizing the hairpin loop that is described in the paper, so you may want to include an image of your own if you do decide not to use that one. I personally think it wouldn't hurt to include a different one even if you do use the current image as well.

Since you all talked about how the mechanism of action does not require the proteins that are typically involved in detaching the RNA molecule, you can maybe include a bit about what sort of benefits that these proteins might provide, or an explanation as to why they have evolved to be a part of the process if they are not necessary.

I know my group-mates have already mentioned this, but do include a quick overview on the process, maybe about how it was discovered or just more generally why it is important for a cell to carry out its functions.

Yalmanso (talk) 03:23, 15 October 2020 (UTC)

Intrinsic Termination Peer Review 5
You have a great start to your explanation of intrinsic termination so far and I see your note about expanding into inhibition as well as archaea and bacteria which will really add to your page. I do have suggestions and areas that would useful to elaborate on:

-Mentioning what intrinsic termenation is (indictating that it is not necessarily a particular sequence but a process/phenomemon) can be helpful here before going straight into the function. This may be included in an introductory paragraph if you choose to include one. You can also discuss when we see this termination versus other types of termination, unless this always occurs in prokaryotes (noting this can further clear your point).

-Elaborate on how and why intrinsic termination prevents interactions with neighboring chromosomes. Also, what does "it" refer to.

-Can you find papers that discuss the regulation of intrinsic termination? This can be a seperate section.

-Including a picture of this hairpin can supplement the section about structure and can improve your wiki page as a whole.

-Mechanism section: What is pausing at end of U-tract? It is not clear what you are referring to. What is Thp nucleation? An elaboration would be useful here.

-There are several grammer mistakes and pronouns that can be specified throughout your draft that can be easily corrected. Nice work!

NWJchem455 (talk) —Preceding undated comment added 04:22, 15 October 2020 (UTC)

Meredith's comments
I think you’ve made a good start on expanding on the current page. I think additional figures may be beneficial in this case. I think y’all have a bit more to fill in, but overall, I think this is headed in the right direction and I am excited to read the final version Good job! Purchalm (talk) 16:40, 15 October 2020 (UTC)