User talk:Zherrera23

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Questions about MTRR
Hello,

I am finding your information about how MTRR works extremely helpful. I am hoping that you might be able to give me some more information. My son has 3 mutations (at least)in MTRR and two of them I have reason to be more serious, even though he only has one copy each. These mutations are MTRR H595Y and K350A. I believe that these mutation make the MTRR enzyme less effective. My son suffers from depression that I know to be caused by large amounts of histamine produced by bacteria in his gut. After a great deal of study I have come to realize that the depression is caused by his not being able to recycle enough SAMe to degrade the histamine through histamine-N-methyl transferase, which requires SAMe as the methyl donor. This excess of histamine is draining his SAMe so I looked at his mutations in the methylation pathway and by giving him, besides a good multivitamin and a few others to support neurotransmitter production, methylfolate and multiple doses of methyl B12 each day I was able to make him feel great for about 2 days. But now he is not feeling quite as well, and I wonder if it is because, due to his mutations in MTRR, he no longer has enough functional MTRR enzyme to recycle enough SAMe to get rid of all the histamine. Do you think this could be possible even with giving him methyl B12 supplements? I gave him a couple grams of methionine and it helped briefly, but the effect didn't last long.

I just had the thought of trying to go through the other pathway (BHMT) so I gave him about 4 gms of TMG. We will see if that works. The MTR pathway is working a lot better than it was, but it isn't quite enough. But even if it does work, I would still like to know the answer to my question because I am trying to learn as much as I can about this.

Kimesie (talk) 18:07, 29 October 2013 (UTC)