VAV1

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.

Function
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Interactions
VAV1 has been shown to interact with:


 * ARHGDIB,
 * Abl gene,
 * Cbl gene
 * EZH2,
 * Grb2,
 * JAK2,
 * Ku70,
 * LAT,
 * LCP2,
 * MAPK1,
 * PIK3R1,
 * PLCG1,
 * PRKCQ,
 * S100B,
 * SHB,
 * SIAH2, and
 * Syk.