Virginia State Route 81

The following highways in Virginia have been known as State Route 81:


 * [[Image:Virginia 81.svg|20px]] State Route 81 (Virginia 1933–1940), Lodi to West Virginia
 * [[Image:Virginia 81.svg|20px]] State Route 81 (Virginia 1940–1958), now State Route 69
 * [[Image:I-81.svg|20px]] Interstate 81 (Virginia), 1957–present