WDR37

WD repeat-containing protein 37 is a protein that in humans is encoded by the WDR37 gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

Clinical
Mutations in this gene have been linked to a number of lesions in humans. These include


 * Corneal opacity/Peters anomaly
 * Coloboma
 * Microcornea
 * Cerebellar hypoplasia
 * Epilepsy
 * Dysmorphic facial features
 * Variable skeletal, cardiac and genitourinary defects
 * Significant neurological impairment with structural brain defects and seizures
 * Poor feeding
 * Poor post-natal growth
 * Death in infancy