WME

WME may refer to:
 * Windows Media Encoder
 * Wireless Multimedia Extensions
 * Wintermute Engine, a graphical adventure game engine by Dead:Code software
 * William Morris Endeavor, a talent agency conglomerate
 * Web-based Mathematics Education
 * Working Memory Element in the Rete algorithm
 * The IATA code for Mount Keith Airport in Western Australia
 * Waze Map Editor
 * National Rail station code for Woodmansterne railway station in London