WXYZ

WXYZ may refer to:


 * The last four letters of the English alphabet
 * In broadcasting, the following stations
 * WXYZ-TV, an ABC-affiliated television station (channel 25, virtual 7) licensed to serve Detroit, Michigan, United States
 * WXYT (AM), a radio station (1270 AM) licensed to serve Detroit, which held the call sign WXYZ from 1930 to 1984
 * WRIF, a radio station (101.1 FM) licensed to serve Detroit, which held the call sign WXYZ-FM from 1948 to 1971