Wei Yan (biologist)

Wei Yan is a Chinese-American reproductive biologist, currently Professor of Medicine at David Geffen School of Medicine at UCLA and Senior Investigator at The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. He is also University Foundation Professor at University of Nevada, Reno, United States and an Elected Fellow of the American Association for the Advancement of Science. He is Director of National Center for Male Reproductive Epigenomics and served as the editor-in-chief of the journal Biology of Reproduction.

Biography
Wei Yan was born in Liaoning, China. He received his MD from China Medical University in 1990 and PhD from University of Turku, Finland in 2000. He completed his post-doc training at Baylor College of Medicine, Houston, TX in 2004. He began his independent career as an Assistant Professor at the University of Nevada, Reno School of Medicine (UNR Med) in 2004. He rose through the ranks and became a full professor in 2013. He is currently Principal Investigator at The Lundquist Institute at Harbor-UCLA Medical Center and Professor of Medicine at David Geffen School of Medicine at UCLA. His research interests include genetic and epigenetic control of fertility, as well as epigenetic contribution of gametes (sperm and eggs) to fertilization, early embryonic development and adulthood health. As a principal investigator, Dr. Yan has been continuously funded by grants from the NIH and various foundations, with a total of ~$17 million in direct cost. He also so far published >150 peer-reviewed research articles and book chapters in high-impact journals with >12,000 citations and a h-index of 63.

Career and Research
After receiving his M.D., Dr. Yan became the Chief Examiner at Coroner office of the Institute of Forensic Science of Liaoning Province, Shenyang, China. While he enjoyed his work as an Examiner and developed better techniques for DNA extraction from crime scene samples, but he soon became fascinated with the research aspect and began to pursue a career in research. He enrolled in the Graduate program in the Department of Forensic Medicine at China Medical University while still working at the coroner's office. The next year he took the opportunity to leave China and work as a visiting scholar in the Department of Medical Genetics, at the University of Turku, Finland. He would stay at the University of Turku to finish in Ph.D. in March 2000 under the supervision of Drs. Jorma Toppari, Ilpo Hutaniemi and Martti Parvinen. After a short stint as a Postdoctoral Associate at University of Turku, he would travel to the United States to work with Dr. Martin M. Matzuk in the Department of Pathology at Baylor College of Medicine in Houston, Texas. It would be here at Baylor College of Medicine that we would get his first professional appointment as an Instructor in the Department of Pathology in 2003. One year later, Dr. Yan would get his first tenure-track Assistant Professorship in the Department of Physiology and Cell Biology at the University of Nevada School of Medicine in Reno Nevada. At UNR, Dr. Yan would go on to be an extremely productive researcher received multiple awards and would climb the ranks to obtain the highest honor bestowed upon Professors; The University of Nevada, Reno Foundation Professor in 2020. During this time he also served as the Editor-in-Chief of Biology or Reproduction, which is the official journal of the Society for the Study of Reproduction (SSR). Having achieved the highest honor at UNR, Dr. Yan would still go on to seek more challenges and moved to Los Angeles to take a Professor of Medicine appointment at the David Geffen School of Medicine at UCLA as well as a Senior Investigator position at The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center in Torrance, California.

Over his almost 30 years of research, Dr. Yan has made significant contributions to the field of Reproductive Biology and Epigenetic Inheritance in the following five areas:

Non-hormonal male contraceptives
Dr. Yan has been innovative in the contraceptives field with the novel idea of developing non-hormonal male contraceptives that disable sperm rather than killing them. His lab first put forward a novel idea for the development of non-hormonal male contraceptives: “Do not kill, but disable sperm”, which led to the discovery of TRIPTONIDE, a natural compound purified from the Chinese herb Tripterygium Wilfordii Hook F. Triptonide acts as a reversible non-hormonal contraceptive agent in mice and monkeys, and established it as a drug candidate for “The Pill” for men. This is the first and ONLY compound discovered in the past fifty years that has been tested on mice and monkeys and found to be efficient, reversible and safe.

Research on cellular and molecular mechanisms that control sperm production and male fertility
Dr. Yan’s lab first discovered the function of motile cilia in the reproductive tracts. In the male, motile ciliary beating functions as an agitator to maintain the constant suspension of immotile testicular sperm during their transit through the efferent ductules in men. This work led to a novel concept that efferent ductal obstructions due to motile ciliopathy represent a new cause of male infertility, which has been validated in clinics. This discovery has changed clinical practice in the diagnosis and treatment of obstructive azoospermia and idiopathic male infertility. In the female, motile cilia in the oviduct/Fallopian tube are essential for oocyte pickup and, therefore, fertility, but dispensable for embryo and sperm transport, which are mostly achieved through smooth muscle contraction. This work solved the long-standing controversy about the role of cilia beating vs. muscle contraction in gamete/embryo transport.

Additionally, using a variety of gene knockout/genome editing technologies, his lab discovered many genetic networks that control the most fundamental cellular and molecular events in spermatogenesis, e.g., sperm connecting piece formation, cytoplasmic removal, global shortening of 3’UTRs,  and delayed translation/uncoupling of transcription and translation, and dynamic changes in poly(A) length and non-A contents.

Discovery of novel small RNA species and their function in germ cells
As a young scientist, Dr. Yan was the first to discover mitochondrial genome-encoded small RNAs (mitosRNAs) and endo-siRNAs in the male germline, as well as meiotic sex chromosome inactivation (MSCI)-escaping X-linked miRNAs and elucidated the functions of all during reproduction.

Transgenerational Epigenetic Inheritance
Based on his work on sperm-borne small RNAs,  he put forward a novel hypothesis regarding the potential role of gamete small RNAs in epigenetic inheritance. His study on the Kit paramutation mouse model first discovered that outcrossing promotes the correction of epimutations through epigenetic reprogramming, whereas intercrossing stabilizes the epimutations and enhances their transmission across multiple generations. Based on the accumulating data on inter- or trans-generational epigenetic inheritance, he and colleagues have come up with several inspiring hypotheses regarding the role of sperm small RNAs and their modifications in mediating epigenetic inheritance. He established the first-ever National Center for Male Reproductive Epigenomics, which is funded by an NCTRI P50 grant from the NICHD with a research focus on the molecular mechanism underlying epigenetic inheritance of lifestyle-induced metabolic syndrome in both humans and mice.

Awards and Service
Dr. Yan has published >165 research articles, reviews and book chapters with >12,700 citations with h-index at 63 as of December 2023 according to Google Scholar. Many of his publications appeared in high-impact journals, including Nature Genetics, Nature Cell Biology, Nature Reviews Genetics, Nature Communications, PNAS, Cell Research, Developmental Cell, Genome Biology, EMBO, and Development. His excellence in research has been recognized by a number of prestigious research awards, including the 2009 Society for the Study of Reproduction (SSR) Young Investigator Award, the 2012 American Society of Andrology (ASA) Young Andrologist Award, the 2013 Nevada Healthcare Hero Award for Research and Technology, the 2017 University of Nevada, Reno Outstanding Researcher Award, the 2018 SSR Research Award and the 2020 Nevada System of Higher Education Regents’ Research Award (mid-career).

Dr. Yan’s mentorship and leadership are as impressive as his research achievements. Dr. Yan has mentored six junior faculty members and trained 16 post-docs and 27 graduate students over the past 16 years. Dr. Yan served on the SSR Program Committee (2007, 2014, and 2016), the SSR Awards Committee (2015-2018), the BOR Board of Reviewing Editors (2009-2013), and as Biology of Reproduction (BOR) Associate Editor (2013-2017). Dr. Yan served as co-Editor-in-Chief of BOR (2017-2021). He is currently a Senior Editor of eLife (2022-) and the Deputy Editor-in-Chief of Andrology (2024-2028), the official journal of the American Society of Andrology (ASA) and the European Academy of Andrology (EAA).

Dr. Yan also serves on the Executive Committee of the North America Testis Workshop (NATW) and chaired the XXVI NATW in 2022. In addition, he served on the ASA Program Committee (2010-2014) and Nominating Committee (2012-2014). He was the program co-Chair for the 2019 ASA annual meeting. Dr. Yan is one of the Board of Directors of ASA (2022-2025).

To recognize his tremendous contributions to his institutions, academic societies and science in general, Dr. Yan was named the University of Nevada, Reno Foundation Professor, the highest honor the University bestows upon its faculty in 2016. Dr. Yan was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2017. He was also named the 2023 SSR Distinguished Fellow.

Awards and affiliations
Some of his awards include:


 * 2009 Society for the Study of Reproduction (SSR) Young Investigator Award
 * 2012 American Society of Andrology (ASA) Young Andrologist Award
 * 2013 Nevada Healthcare Hero Award for Research and Technology
 * 2017 University of Nevada, Reno Outstanding Researcher Award
 * 2018 SSR Research Award and the 2020 Nevada System of Higher Education Research Award

He was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2017.