Weightlifting at the 2023 Pan American Games – Women's +81 kg

The women's +81 kg competition of the weightlifting events at the 2023 Pan American Games in Santiago, Chile, was held on 24 October at the Gimnasio Chimkowe.

Each lifter performed in both the snatch and clean and jerk lifts, with the final score being the sum of the lifter's best result in each. The athlete received three attempts in each of the two lifts; the score for the lift was the heaviest weight successfully lifted. This weightlifting event was limited to competitors with a minimum of 81 kilograms of body mass.

Results
The results were as follows: