West Brule, South Dakota

West Brule is an unincorporated community and census-designated place (CDP) within the Lower Brule Indian Reservation in Lyman County, South Dakota, United States. It was first listed as a CDP prior to the 2020 census. The population of the CDP was 538 at the 2020 census.

It is in the northeast part of the county, 3 mi west of Lower Brule and 1 mi south of Lake Sharpe on the Missouri River.