Wikipedia:Cochrane Collaboration/Cochrane UK/Cochrane Reviews

New and updated Cochrane Systematic Reviews are published every week. Prior to publication, each new review is discussed at a weekly Analysis of Review Group Output (ARGO) meeting by a group of health and communications specialists at Cochrane UK. The Cochrane reviews listed here are those that have been flagged up during this meeting as being of particular strength, importance, and interest to benefit the evidence base of health-related articles on Wikipedia.

This table presents key information about these reviews to anyone wishing to develop Wikipedia medicine articles with Cochrane evidence. Part of the table is updating weekly by someone at Cochrane UK, the other part is where interested users can help link and develop relevant articles on Wikipedia.

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Recent Cochrane Reviews
! colspan="6" style="border-bottom: 3px solid grey; color: red; text-align: left;" | Updated weekly ! colspan="2" style="border-bottom: 3px solid grey; color: red; text-align: left;" | Please edit

!	Data-sort-type=”number” | #	!! Review Group	!!Review Research Question	!!Conclusions	!! Date of Publication	!!DOI	!!Suggested Article(s)	!!Action

1 Renal 2 Occupational Safety & Health 3 Depression, Anxiety & Neurosis 4 Heart Group 5 Pregnancy and Childbirth Group 6 Menstrual Disorders & Subfertility 7 Pregnancy & Childbirth 8 Public Health 9 Lung Cancer 10 Hepato-Biliary 11 Dementia and Cognitive Improvement Group 12 Depression, Anxiety and Neurosis Group 13 Eyes and Vision Group 14 Injuries Group 15 Acute Respiratory Infections Group
 * This review aimed to assess the effectiveness and complications of ESWL for kidney stones compared with PCNL or RIRS.
 * Changed
 * 2014/11
 * 10.1002/14651858.CD007044.pub3
 * Extracorporeal shock wave lithotripsy
 * To evaluate the effectiveness of interventions aimed at reducing work disability in employees with depressive disorders.
 * Changed
 * 2014/12
 * 10.1002/14651858.CD006237.pub3
 * Mood disorder
 * To evaluate the effectiveness of psychological therapies and antidepressant medication, alone and in combination, for the treatment of depressive disorder in children and adolescents.
 * Unchanged
 * 2014/11
 * 10.1002/14651858.CD008324.pub3
 * Major depressive disorderDepression in childhood and adolescence
 * To conduct an overview of Cochrane systematic reviews to provide a contemporary review of the evidence for delivery of cardiac rehabilitation, to identify opportunities for merging or splitting existing Cochrane reviews, and to identify current evidence gaps to inform new cardiac rehabilitation systematic review titles.
 * New review
 * 2014/12
 * 10.1002/14651858.CD011273.pub2.
 * Cardiopulmonary rehabilitation
 * To assess the effects of all interventions in the resolution or reduction of nipple pain and the impact of the interventions on other outcomes such as nipple trauma, nipple infections, breast mastitis, breastfeeding duration, breastfeeding exclusivity, and maternal satisfaction.
 * New review
 * 2014/12
 * 10.1002/14651858.CD007366.pub2
 * Breastfeeding difficulties
 * Little evidence
 * To summarise evidence derived from Cochrane systematic reviews on the clinical safety and effectiveness of solid agents, gel agents, liquid agents and pharmacological agents, used as adjuvants to prevent formation of adhesions after gynaecological pelvic surgery.
 * New review
 * 2015/01
 * 10.1002/14651858.CD011254.pub2
 * To assess the effects of administering antibiotic regimens for intra-amniotic infection on maternal and perinatal morbidity and mortality and on infection-related complications.
 * New review
 * 2014/12
 * 10.1002/14651858.CD010976.pub2
 * Chorioamnionitis
 * To evaluate the effects of community wide, multi-strategic interventions upon population levels of physical activity.
 * Changed
 * 2015/01
 * 10.1002/14651858.CD008366.pub3
 * Physical exercise
 * To assess the effects of different palliative radiotherapy regimens on improving thoracic symptoms in patients with locally advanced or metastatic non-small cell lung cancer who are not suitable for radical RT given with curative intent. To assess the effects of radiotherapy dose on overall survival in patients with locally advanced or metastatic non-small cell lung cancer who are not suitable for radical RT given with curative intent.
 * Changed
 * 2015/01
 * 10.1002/14651858.CD002143.pub4
 * Distress_in_cancer_caregivingPalliative_careEnd-of-life_care
 * To determine the diagnostic accuracy of transient elastography for diagnosis and staging hepatic fibrosis in people with alcoholic liver disease when compared with liver biopsy. To identify the optimal cut-off values for differentiating the five stages of hepatic fibrosis.
 * New review
 * 2015/01
 * 10.1002/14651858.CD010542.pub2
 * CirrhosisTransient elastographyAlcoholic liver diseaseLiver biopsy
 * The primary objective of this review was to determine the diagnostic accuracy of the Mini-Cog for detecting Alzheimer's disease dementia and related dementias in a community setting.
 * New review
 * 2015/02
 * 10.1002/14651858.CD010860
 * General_Practitioner_Assessment_of_Cognition
 * Nothing much interesting to report.
 * The objective of this review was to determine the effects of exercise therapy (ET) for patients with Chronic Fatigue Syndrome as compared with any other intervention or control.
 * Unchanged
 * 2015/02
 * 10.1002/14651858.CD003200.pub3
 * Chronic fatigue syndromeExercise therapy
 * The objective of this review was to examine the effectiveness of statins compared with other treatments, no treatment, or placebo in delaying the onset and progression of age-related macular degeneration (AMD).
 * Unchanged
 * 2015/02
 * 10.1002/14651858.CD006927.pub4
 * StatinMacular degeneration
 * The objective was to determine the diagnostic accuracy of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy (TIC) in adult trauma patients with bleeding, using a reference standard of prothrombin time ratio and/or the international normalized ratio.
 * New Review
 * 2015/02
 * 10.1002/14651858.CD010438.pub2
 * ThromboelastographyCoagulopathy
 * To determine the effectiveness of repairing buildings damaged by dampness and mould in order to reduce or prevent respiratory tract symptoms, infections and symptoms of asthma.
 * Unchanged
 * 2015/02
 * 10.1002/14651858.CD007897.pub3
 * Damp_(structural)

16 Pain, Palliative and Supportive Care Group 17 Schizophrenia Group 18 Acute Respiratory Infections Group 19 Ear, Nose and Throat Disorders Group 20 Consumers and Communication Group 21 Stroke Group 22 Heart Group 23 Injuries Group 24 Depression, Anxiety and Neurosis Group 25 Infectious Diseases Group 26 Musculoskeletal Group 27 Wounds Group 28 Tobacco Addiction Group 29 Breast Cancer Group 30 Stroke Group 31 Incontinence Group 32 Acute Respiratory Infections Group 33 Developmental, Psychosocial and Learning Problems Group 34 Oral Health Group 35 Menstrual Disorders and Subfertility Group 36 Fertility Regulation Group 37 Menstrual Disorders and Subfertility Group 38 Cystic Fibrosis and Genetic Disorders Group 39 Drugs and Alcohol Group 40 Epilepsy Group 41 Pregnancy and Childbirth Group 42 Pain, Palliative and Supportive Care Group 43 Effective Practice and Organisation of Care Group 44 Anaesthesia Group 45 Depression, Anxiety and Neurosis Group 46 Anaesthesia Group 47 Pain, Palliative and Supportive Care Group 48 Bone, Joint and Muscle Trauma Group 49 Multiple Sclerosis and Rare Diseases of the Central Nervous System Group 50 Pain, Palliative and Supportive Care Group 51 Renal Group 52 Musculoskeletal Group 53 Heart Group 54 Neuromuscular Disease Group 55 Pain, Palliative and Supportive Care Group 56 Inflammatory Bowel Disease and Functional Bowel Disorders Group 57 Skin Group 58 Skin Group 59 Musculoskeletal Group Adalimumab
 * To assess the effectiveness and tolerability of oxycodone for pain in adults with cancer.
 * New Review
 * 2015/02
 * 10.1002/14651858.CD003870.pub5
 * OxycodoneCancer pain
 * To examine the clinical effects and safety of perphenazine for those with schizophrenia and schizophrenia-like psychoses.
 * Unchanged
 * 2015/03
 * 10.1002/14651858.CD003443.pub3
 * SchizophreniaPerphenazine
 * To compare the effectiveness of azithromycin to amoxycillin or amoxycillin/clavulanic acid (amoxyclav) in the treatment of acute lower respiratory tract infections (LRTI), in terms of clinical failure, incidence of adverse events and microbial eradication.
 * Unchanged
 * 2015/03
 * 10.1002/14651858.CD001954.pub4
 * Lower respiratory tract infectionAzithromycinAmoxicillin
 * To assess the effects of positive pressure therapy (e.g. the Meniett device) on the symptoms of Ménière's disease or syndrome.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD008419.pub2
 * Ménière's disease
 * To assess the effects of personalised care planning for adults with long-term health conditions compared to usual care (i.e. forms of care in which active involvement of patients in treatment and management decisions is not explicitly attempted or achieved).
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010523.pub2
 * To determine: (1) whether interventions improve community ambulation for stroke survivors, and (2) if any specific intervention method improves community ambulation more than other interventions.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010200.pub2
 * Stroke
 * To assess the effects of hormone therapy for the prevention of cardiovascular disease in post-menopausal women, and whether there are differential effects between use in primary or secondary prevention.
 * Unchanged
 * 2015/03
 * 10.1002/14651858.CD002229.pub4
 * Hormone replacement therapy (menopause)Cardiovascular disease
 * To compare the effect and cost of cell salvage with those of standard care in individuals undergoing abdominal or thoracic trauma surgery.
 * Unchanged
 * 2015/01
 * 10.1002/14651858.CD007379.pub2
 * Trauma surgeryIntraoperative blood salvage
 * To assess the effects of therapist-supported Internet cognitive behavioural therapy (CBT) on remission of anxiety disorder diagnosis and reduction of anxiety symptoms in adults as compared to waiting list control, unguided CBT, or face-to-face CBT. Effects of treatment on quality of life and patient satisfaction with the intervention were also assessed.
 * Unchanged
 * 2015/01
 * 10.1002/14651858.CD011565
 * Cognitive behavioral therapyAnxiety disorder
 * To evaluate the efficacy and safety of the artemisinin-naphthoquine combination for treating adults and children with uncomplicated P. falciparum malaria.
 * New Review
 * 2015/02
 * 10.1002/14651858.CD011547
 * Plasmodium falciparum
 * To assess the benefits and harms of braces and foot/ankle orthoses in the treatment of patients with osteoarthritis (OA) of the knee.
 * Unchanged
 * 2015/03
 * 10.1002/14651858.CD004020.pub3
 * Osteoarthritis
 * The objective of this review was to assess the effects of honey compared with alternative wound dressings and topical treatments on the of healing of acute (e.g. burns, lacerations) and/or chronic (e.g. venous ulcers) wounds.
 * Changed
 * 2015/03
 * 10.1002/14651858.CD005083.pub4
 * HoneyDressing (medical)WoundBurnVenous ulcer
 * The primary objective of this review was to assess the effectiveness of interventions to increase adherence to medications for smoking cessation, such as NRT, bupropion, nortriptyline and varenicline (and combination regimens). This was considered in comparison to a control group, typically representing standard care.
 * New Review
 * 2015/02
 * 10.1002/14651858.CD009164.pub2
 * Smoking cessationNicotine replacement therapyBupropionNortriptylineVarenicline
 * To assess the effects of conservative (non-surgical and non-pharmacological) interventions for preventing clinically-detectable upper-limb lymphoedema after breast cancer treatment.
 * New Review
 * 2015/02
 * 10.1002/14651858.CD009765.pub2
 * LymphedemaBreast cancer management
 * To determine: (1) whether interventions improve community ambulation for stroke survivors, and (2) if any specific intervention method improves community ambulation more than other interventions.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010200.pub2
 * Stroke
 * To evaluate the efficacy of transurethral radiofrequency collagen denaturation, compared with other interventions, in the treatment of women with UI.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010217.pub2
 * Urinary incontinenceCollagen
 * To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media (AOM) in infants and children.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010089.pub2
 * Influenza vaccineOtitis media
 * To assess the efficacy of non-speech oral motor treatment (NSOMT) in treating children with developmental speech sound disorders who have speech errors.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD009383.pub2
 * Speech disorder
 * To assess the effects of different xylitol-containing products for the prevention of dental caries in children and adults.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010743.pub2
 * Dental cariesXylitol
 * To assess the short-term (within 12 months) effectiveness and safety of add-back therapy for women using GnRH analogues for uterine fibroids associated with excessive uterine bleeding, pelvic pain, or urinary symptoms.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD010854.pub2
 * Uterine fibroidGonadotropin-releasing hormoneHot flash
 * To determine the effects of hormonal contraceptives on lactation and infant growth
 * Unchanged
 * 2015/03
 * 10.1002/14651858.CD003988.pub2
 * Hormonal contraceptionLactation
 * To assess the effectiveness and safety of endometrial injury performed before embryo transfer in women undergoing assisted reproductive techniques (ART).
 * Changed
 * 2015/03
 * 10.1002/14651858.CD009517.pub3
 * Assisted reproductive technology
 * To evaluate the effects of CFTR potentiators on clinically important outcomes in children and adults with cystic fibrosis.
 * New Review
 * 2015/03
 * 10.1002/14651858.CD009841.pub2
 * Cystic fibrosis
 * To assess the efficacy and safety of baclofen for people with alcohol withdrawal syndrome (AWS).
 * Unchanged
 * 2015/04
 * 10.1002/14651858.CD008502.pub4
 * Alcohol withdrawal syndromeBaclofen
 * To determine: (1) The effects on seizures of vagus nerve stimulation (VNS) compared to controls e.g. high-level stimulation compared to low-level stimulation (presumed sub-therapeutic dose); and (2) The adverse effect profile of VNS compared to controls e.g. high-level stimulation compared to low-level stimulation.
 * Unchanged
 * 2015/04
 * 10.1002/14651858.CD002896.pub2
 * Vagus nerve stimulationEpilepsy
 * The objective of this review was to assess the effects of external cephalic version (ECV) at or near term on measures of pregnancy outcome. Methods of facilitating ECV, and ECV before term are reviewed separately.
 * Unchanged
 * 2015/04
 * 10.1002/14651858.CD000083.pub3
 * External cephalic version
 * To assess the effectiveness and tolerability of buprenorphine for pain in adults and children with cancer.
 * Unchanged
 * 2015/03
 * 10.1002/14651858.CD009596.pub4
 * BuprenorphineCancer pain
 * To assess the evidence on the effectiveness of available strategies that focus on delivery and appropriate use of insecticide-treated bednets (ITNs).
 * New Review
 * 2015/03
 * 10.1002/14651858.CD009186.pub2
 * Mosquito netGlobal health
 * To assess the effect of melatonin on pre- and postoperative anxiety in adults when comparing melatonin with placebo or when comparing melatonin with benzodiazepines.
 * New Review
 * 2015/04
 * 10.1002/14651858.CD009861.pub2
 * Preoperational_anxiety
 * To assess the effects of debriefing interventions compared with standard postnatal care for the prevention of psychological trauma in women following childbirth.
 * Unchanged
 * 2015/04
 * 10.1002/14651858.CD007194.pub2
 * Childbirth
 * To estimate the effectiveness of preoperative or intraoperative warming, or both, of intravenous and irrigation fluids in preventing perioperative hypothermia and its complications during surgery in adults.
 * New Review
 * 2015/04
 * 10.1002/14651858.CD009891.pub2
 * HypothermiaSurgery
 * To assess the clinical efficacy and safety of feverfew monopreparations versus placebo for preventing migraine.
 * Unchanged
 * 2015/04
 * 10.1002/14651858.CD002286.pub3
 * Tanacetum partheniumMigraine
 * To assess the effects (benefits and harms) of red blood cell transfusion in people undergoing surgery for hip fracture.
 * New
 * 2015/04
 * 10.1002/14651858.CD009699.pub2
 * Hip fracture
 * To assess the benefit and safety of dimethyl fumarate as monotherapy or combination therapy versus placebo or other approved disease-modifying drugs (interferon beta, glatiramer acetate, natalizumab, mitoxantrone, fingolimod, teriflunomide, alemtuzumab) for patients with MS.
 * New
 * 2015/04
 * 10.1002/14651858.CD011076.pub2
 * Multiple sclerosis
 * To evaluate the efficacy of corticosteroids in treating cancer-related pain in adults.
 * New
 * 2015/04
 * 10.1002/14651858.CD010756.pub2
 * CorticosteroidCancer pain
 * To determine the diagnostic accuracy of state (one time), minimally invasive clinical symptoms, signs and tests to be used as screening tests for detecting water-loss dehydration in older people by systematically reviewing studies that have measured a reference standard and at least one index test in people aged 65 years and over. Water-loss dehydration was defined primarily as including everyone with either impending or current water-loss dehydration (including all those with serum osmolality ≥ 295 mOsm/kg as being dehydrated).
 * New
 * 2015/04
 * 10.1002/14651858.CD009647.pub2
 * Dehydration
 * To synthesise the available evidence regarding the benefits and harms of vertebroplasty for treatment of osteoporotic vertebral fractures.
 * New
 * 2015/04
 * 10.1002/14651858.CD006349.pub2
 * Percutaneous vertebroplasty
 * To assess the potential benefits of influenza vaccination for primary and secondary prevention of cardiovascular disease.
 * Changed
 * 2015/05
 * 10.1002/14651858.CD005050.pub3
 * Cardiovascular diseaseInfluenza vaccine
 * To assess the effects of antiviral treatments alone or in combination with any other therapy for Bell’s palsy.
 * Unchanged
 * 2015/05
 * 10.1002/14651858.CD001869.pub5
 * Bell's palsy
 * To determine the efficacy and tolerability of selective serotonin re-uptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) compared to placebo and other active interventions in the prevention of episodic and chronic tension-type headache in adults.
 * Unchanged
 * 2015/05
 * 10.1002/14651858.CD011681
 * Tension headacheSelective serotonin reuptake inhibitorSerotonin–norepinephrine reuptake inhibitor
 * The objectives of this review were to assess the efficacy and safety of anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease.
 * New
 * 2015/05
 * 10.1002/14651858.CD007572.pub2
 * Crohn's disease
 * To assess the effects of interventions (except laser and light-based therapies alone) for hirsutism.
 * New
 * 2015/04
 * 10.1002/14651858.CD010334.pub2
 * Hirsutism
 * To assess the efficacy and safety of treatments for rosacea.
 * Changed
 * 2015/04
 * 10.1002/14651858.CD003262.pub5
 * Rosacea
 * To assess the benefit and harms of adalimumab, etanercept, golimumab, and infliximab (TNF-alpha inhibitors) in people with ankylosing spondylitis.
 * New
 * 2015/04
 * 10.1002/14651858.CD005468.pub2
 * Ankylosing spondylitis

Etanercept

Golimumab

Infliximab 60 Drugs and Alcohol Group 61 Injuries Group 62 Pain, Palliative and Supportive Care Group 63 Bone, Joint and Muscle Trauma Group 64 Menstrual Disorders and Subfertility Group 65 Cystic Fibrosis and Genetic Disorders Group 66 Tobacco Addiction Group 67 Gynaecological Cancer Group 68 Upper Gastrointestinal and Pancreatic Diseases Group 69 Heart Group 70 Wound Group 71 Pregnancy and Childbirth Group 72 Colorectal Cancer Group 73 Breast Cancer Group 74 Skin Group 75 Inflammatory Bowel Disease and Functional Bowel Disorders Group 76 Eyes and Vision Group 77 Pregnancy and Childbirth Group 78 Breast Cancer Group 79 Heart Group 80 Pregnancy and Childbirth Group 81 Musculoskeletal Group 82 Acute Respiratory Infections Group 83 Epilepsy Group 84 Cystic Fibrosis and Genetic Disorders Group 85 Oral Health Group To evaluate the effects of water fluoridation (artificial or natural) on dental fluorosis. 86 Acute Respiratory Infections Group 87 Dementia and Cognitive Improvement Group 88 Gynaecological Cancer Group 89 Vascular Group 90 Incontinence Group 91 Neuromuscular Disease Group 92 Skin Group 93 Back Group 94 Pregnancy and Childbirth Group 95 Depression, Anxiety and Neurosis Group 96 Anaesthesia, Critical & Emergency Care Group 97 Vascular Group 98 Pain, Palliative & Supportive Care Group 99 Fertility Regulation Group 100 Renal Group 101 Heart Group 102 Pregnancy and Childbirth Group 103 Pregnancy and Childbirth Group 104 Methodology Review Group 105 Pregnancy and Childbirth Group 106 Lung Cancer Group 107 Skin Group 108 Heart Group 109 Anaesthesia, Critical and Emergency Care Group 110 Epilepsy Group 111 Bone, Joint and Muscle Trauma Group 112 Heart Group 113 Eyes and Vision Group 114 Pregnancy and Childbirth Group 115 Skin Group 116 Menstrual Disorders and Subfertility Group 117 Schizophrenia Group 118 Pregnancy and Childbirth Group 119 Heart Group 120 Childhood Cancer Group 121 Hypertension Group 122 Airways Group 123 Stroke Group 124 Pregnancy and Childbirth Group 125 Wounds Group 126 Stroke Group 127 Stroke Group 128 Menstrual Disorders and Subfertility Group 129 Pregnancy and Childbirth Group 130 Multiple Sclerosis and Rare Diseases of the Central Nervous System Group 131 Vascular Group 132 Bone, Joint and Muscle Trauma Group 133 Eyes and Vision Group 134 Wounds Group 135 Pain, Palliative and Supportive Care Group 136 Pain, Palliative and Supportive Care Group 137 Metabolic and Endocrine Disorders Group 138 Movement Disorders Group 139 Skin Group 140 Gynaecological Cancer Group 141 Pain, Palliative and Supportive Care Group 142 Pain, Palliative and Supportive Care Group 143 ENT Group 144 Musculoskeletal Group 145 Pregnancy and Childbirth Group 146 Eyes and Vision Group 147 Pregnancy and Childbirth Group 148 Pregnancy and Childbirth Group 149 Developmental, Psychosocial and Learning Problems Group Secondary objectives were to determine the effect of sleep positioning systems on: (1) number or frequency of hip problems; (2) sleep patterns and quality; (3) quality of life of the child and family; (4) pain; and (5) physical functioning. We also sought to identify any adverse effects from using sleep positioning systems. 150 Pregnancy and Childbirth Group 151 Developmental, Psychosocial and Learning Problems Group 152 Bone, Joint and Muscle Trauma Group 153 Gynaecological, Neuro-oncology and Orphan Cancer Group 154 Heart Group 1. Increasing omega 6 (Linoleic acid (LA), Gamma-linolenic acid (GLA), Dihomo-gamma-linolenic acid (DGLA), Arachidonic acid (AA), or any combination) intake in place of saturated or monounsaturated fats or carbohydrates for the primary prevention of cardiovascular disease. 2. Decreasing omega 6 (LA, GLA, DGLA, AA, or any combination) intake in place of carbohydrates or protein (or both) for the primary prevention of cardiovascular disease. 155 Eyes and Vision Group 156 Anaesthesia, Critical and Emergency Care Group 157 Anaesthesia, Critical and Emergency Care Group 158 Airways Group 159 Oral Health Group 160 Metabolic and Endocrine Disorders Group 161 Developmental, Psychosocial and Learning Problems Group 162 Acute Respiratory Infections Group 163 Eyes and Vision Group 164 Kidney and Transplant 165 Upper GI and Pancreatic Diseases Helicobacter pylori eradication protocols 166 Common Mental Disorders Chronic fatigue syndrome 167 Epilepsy Ketogenic diet 168 Back and Neck Exercise therapy Yamato TP, Maher CG, Saragiotto BT, Hancock MJ, Ostelo RWJG, Cabral CMN, Menezes Costa LC, Costa LOP. Pilates for low back pain. Cochrane Database of Systematic Reviews 2015, Issue 7. Art. No.: CD010265. DOI: 10.1002/14651858.CD010265.pub2. (Evidently Cochrane blog: http://www.evidentlycochrane.net/pilates-new-evidence-on-help-for-low-back-pain/ and blogshot in July 2015) 169 Drugs and Alcohol Opioid 170 Pain, Palliative and Supportive Care 171 Drugs and Alcohol Care Opioid 172 Tobacco Addiction 173 Pregnancy and Childbirth 174 Airways
 * To evaluate the effectiveness of psychosocial interventions for treating benzodiazepines (BZD) harmful use, abuse or dependence compared to pharmacological interventions, no intervention, placebo or a different psychosocial intervention on reducing the use of BZDs in opiate dependent and non-opiate dependent groups.
 * New
 * 2015/05
 * 10.1002/14651858.CD009652.pub2
 * Benzodiazepine
 * To assess the effects of using fresher versus older red blood cells in people requiring a red blood cell transfusion.
 * New
 * 2015/05
 * 10.1002/14651858.CD010801.pub2
 * Blood transfusion
 * To determine the effectiveness and differential efficacy of laxatives used to manage constipation in people receiving palliative care.
 * Changed
 * 2015/05
 * 10.1002/14651858.CD003448.pub4
 * LaxativePalliative care
 * To evaluate the effects (benefits and harms) of different methods of surgical treatment for acute fracture or non-union of the middle third of the clavicle.
 * Changed
 * 2015/05
 * 10.1002/14651858.CD007428.pub3
 * Clavicle fracture
 * To evaluate the effect of flushing fallopian tubes with oil- or water-soluble contrast media on live birth and pregnancy rates in women with subfertility.
 * Unchanged
 * 2015/05
 * 10.1002/14651858.CD003718.pub4
 * InfertilityFallopian tube
 * To examine the evidence that psychological interventions improve the ability of people with sickle cell disease to cope with their condition.
 * Unchanged
 * 2015/05
 * 10.1002/14651858.CD001916.pub3
 * Sickle-cell disease
 * To determine whether incentives and contingency management programmes lead to higher long-term quit rates.
 * Changed
 * 2015/05
 * 10.1002/14651858.CD004307.pub5
 * Smoking cessation
 * To determine the benefits and risks of PARP inhibitors for the treatment of epithelial ovarian cancer (EOC).
 * Changed
 * 2015/05
 * 10.1002/14651858.CD007929.pub3
 * Ovarian cancer
 * The objective of this review is to determine the role of preoperative chemotherapy in the treatment of patients with resectable thoracic esophageal carcinoma.
 * Unchanged
 * 2015/05
 * 10.1002/14651858.CD001556.pub3
 * Esophageal cancer
 * To systematically assess the efficacy and safety of Tong-xin-luo capsules in preventing cardiovascular events after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).
 * New
 * 2015/05
 * 10.1002/14651858.CD010237.pub2
 * Coronary artery diseasePercutaneous coronary intervention
 * To assess the effects of negative pressure wound therapy for treating pressure ulcers in any care setting.
 * New
 * 2015/05
 * 10.1002/14651858.CD011334.pub2
 * Pressure ulcerNegative-pressure wound therapy
 * To assess the effects of education during pregnancy to increase energy and protein intake, or of actual energy and protein supplementation, on energy and protein intake, and the effect on maternal and infant health outcomes.
 * Changed
 * 2015/06
 * 10.1002/14651858.CD000032.pub3
 * Pregnancy
 * To compare water infusion techniques with standard air insufflation, specifically evaluating technical quality and screening efficacy, as well as patients’ acceptance of the water infusion procedure.
 * New
 * 2015/05
 * 10.1002/14651858.CD009863.pub2
 * Colorectal cancer
 * To assess the effects of psychological interventions on psychological morbidities, quality of life and survival among women with non-metastatic breast cancer.
 * New
 * 2015/05
 * 10.1002/14651858.CD008729.pub2
 * Breast cancer
 * To assess the effects and safety of sentinel lymph node biopsy (SLNB) followed by completion lymph node dissection (CLND) for the treatment of localised primary cutaneous melanoma.
 * New
 * 2015/05
 * 10.1002/14651858.CD010307.pub2
 * Melanoma
 * The primary objective was to evaluate the efficacy and safety of oral budesonide for the induction of remission in Crohn's disease.
 * Changed
 * 2015/06
 * 10.1002/14651858.CD000296.pub4
 * Crohn's diseaseBudesonide
 * The objective of this review was to assess the effects of topical antihistamines and mast cell stabilisers, alone or in combination, for use in treating seasonal and perennial allergic conjunctivitis.
 * New
 * 2015/06
 * 10.1002/14651858.CD009566.pub2
 * Allergic conjunctivitis
 * To assess the impact of Hib and viral Influenza vaccinations during pregnancy on maternal, neonatal and infant health outcomes compared to placebo/control.
 * New
 * 2015/06
 * 10.1002/14651858.CD009982.pub2
 * The objective of this review was to compare taxane-containing chemotherapy regimens with regimens not containing a taxane in the management of women with metastatic breast cancer.
 * Unchanged
 * 2015/06
 * 10.1002/14651858.CD003366.pub3
 * Metastatic breast cancerChemotherapyTaxane
 * To assess the effect of reducing saturated fat intake and replacing it with carbohydrate (CHO), polyunsaturated (PUFA) or monounsaturated fat (MUFA) and/or protein on mortality and cardiovascular morbidity, using all available randomised clinical trials.
 * New
 * 2015/06
 * 10.1002/14651858.CD011737
 * Cardiovascular diseaseSaturated fat
 * To evaluate the effectiveness of diet or exercise, or both, interventions for preventing excessive weight gain during pregnancy and associated pregnancy complications.
 * Changed
 * 2015/06
 * 10.1002/14651858.CD007145.pub3
 * Pregnancy
 * The objective was to assess the benefits and harms of selective serotonin reuptake inhibitors (SSRIs) in the treatment of fibromyalgia.
 * New
 * 2015/06
 * 10.1002/14651858.CD011735
 * Selective serotonin reuptake inhibitorFibromyalgia
 * Added to talk page; 2009 JAMA meta-analysis referenced in fibromyalgia article has different results to Cochrane SR.
 * To evaluate the effectiveness of exercise for altering the occurrence, severity or duration of acute respiratory infections.
 * New
 * 2015/06
 * 10.1002/14651858.CD010596.pub2
 * Influenza-like illness
 * To evaluate the efficacy and tolerability of lacosamide when used as an add-on treatment for patients with drug-resistant partial epilepsy.
 * New
 * 2015/06
 * 10.1002/14651858.CD008841.pub2
 * EpilepsyLacosamide
 * To determine the effectiveness and acceptability of positive expiratory pressure (PEP) devices compared to other forms of physiotherapy as a means of improving mucus clearance and other outcomes in people with cystic fibrosis.
 * Changed
 * 2015/06
 * 10.1002/14651858.CD003147.pub4
 * Cystic fibrosis
 * To evaluate the effects of water fluoridation (artificial or natural) on the prevention of dental caries.
 * New
 * 2015/06
 * 10.1002/14651858.CD010856.pub2
 * Water fluoridationDental cariesDental fluorosis
 * To assess the effects of antibiotics for children with acute otitis media (AOM).
 * Unchanged
 * 2015/06
 * 10.1002/14651858.CD000219.pub4
 * Otitis media
 * To determine the diagnostic accuracy of regional cerebral blood flow (rCBF) single-photon emission computed tomography (SPECT) for diagnosing frontotemporal dementia (FTD) in populations with suspected dementia in secondary/tertiary healthcare settings and in the differential diagnosis of FTD from other dementia subtypes.
 * New
 * 2015/06
 * 10.1002/14651858.CD010896.pub2
 * Frontotemporal dementiaSingle-photon emission computed tomography
 * To assess the effects of early postoperative radiotherapy versus radiotherapy delayed until tumour progression for low-grade intracranial gliomas in people who had initial biopsy or surgical resection.
 * New
 * 2015/06
 * 10.1002/14651858.CD009229.pub2
 * Glioma
 * To assess the effectiveness of oral direct thrombin inhibitors (DTIs) and oral factor Xa inhibitors for the treatment of deep vein thrombosis (DVT).
 * New
 * 2015/06
 * 10.1002/14651858.CD010956.pub2
 * Deep vein thrombosisDirect Xa inhibitorDirect thrombin inhibitorAnticoagulant
 * To assess the clinical effects of mid-urethral sling (MUS) operations for the treatment of stress urinary incontinence (SUI), urodynamic stress incontinence (USI) or mixed urinary incontinence (MUI) in women.
 * Unchanged
 * 2015/07
 * 10.1002/14651858.CD006375.pub3
 * Stress incontinenceUrinary incontinence
 * To assess the effects of antiviral treatments alone or in combination with any other therapy for Bell’s palsy.
 * Changed
 * 2015/07
 * 10.1002/14651858.CD001869.pub6
 * Bell's palsy
 * To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments.
 * Unchanged
 * 2015/07
 * 10.1002/14651858.CD009864.pub2
 * Atopic dermatitisTacrolimus
 * To determine the effects of the Pilates method for patients with non-specific acute, subacute or chronic low back pain.
 * New
 * 2015/07
 * 10.1002/14651858.CD010265.pub2
 * PilatesLow back pain
 * To assess the effectiveness and safety of repeat dose(s) of prenatal corticosteroids.
 * Unchanged
 * 2015/07
 * 10.1002/14651858.CD003935.pub4
 * Corticosteroid
 * To identify all randomised controlled trials of pharmacological agents or natural products for self harm in adults, and to conduct meta-analyses (where possible) to compare the effects of specific treatments with comparison types of treatment (e.g., placebo/alternative pharmacological treatment) for self harming patients.
 * New
 * 2015/07
 * 10.1002/14651858.CD011777
 * Self-harm
 * We assessed the benefits and harms of prothrombin complex concentrate (PCC) compared with fresh frozen plasma in the acute medical and surgical setting involving vitamin K antagonist-treated bleeding and non-bleeding patients.
 * New
 * 2015/07
 * 10.1002/14651858.CD010555.pub2
 * Prothrombin complex concentrate
 * To compare the efficacy and safety of the ambulatory conservative hemodynamic correction of venous insufficiency method (cure conservatrice et hémodynamique de l'insuffisance veineuse en ambulatoire (CHIVA)) with alternative therapeutic techniques to treat varicose veins.
 * Unchanged
 * 2015/06
 * 10.1002/14651858.CD009648.pub3
 * Varicose veins
 * To assess the analgesic efficacy and adverse effects of a single oral dose of diclofenac for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes.
 * Changed
 * 2015/07
 * 10.1002/14651858.CD004768.pub3
 * Diclofenac
 * Our aim was to examine the outcomes of intrauterine contraception (IUC) insertion immediately after placenta delivery (within 10 minutes), especially when compared with insertion at other postpartum times. We focused on successful IUC placement (insertion), subsequent expulsion, and method use.
 * Changed
 * 2015/06
 * 10.1002/14651858.CD003036.pub3
 * Intrauterine device
 * The aim of this review was to assess benefits and harms of different nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opioids in the treatment of adult patients with acute renal colic and if possible to determine which medication (or class of medications) are more appropriate for this purpose. Clinically relevant outcomes such as efficacy of pain relief, time to pain relief, recurrence of pain, need for rescue medication and side effects were explored.
 * New
 * 2015/07
 * 10.1002/14651858.CD006027.pub2
 * Nonsteroidal anti-inflammatory drugRenal colic
 * This review aimed to examine the efficacy of psychosocial interventions for smoking cessation in patients with coronary heart disease in short-term (6 to 12 month follow-up) and long-term (more than 12 months). Moderators of treatment effects (i.e. intervention types, treatment dose, methodological criteria) were used for stratification.
 * Unchanged
 * 2015/07
 * 10.1002/14651858.CD006886.pub2
 * Coronary artery disease
 * To assess the effects of daily oral iron supplements for pregnant women, either alone or in conjunction with folic acid, or with other vitamins and minerals as a public health intervention in antenatal care.
 * Unchanged
 * 2015/07
 * 10.1002/14651858.CD004736.pub5
 * To assess the effect of n-3 LCPUFA supplementation in pregnant and/or breastfeeding women on allergy outcomes (food allergy, atopic dermatitis (eczema), allergic rhinitis (hay fever) and asthma/wheeze) in their children.
 * New
 * 2015/07
 * 10.1002/14651858.CD010085.pub2
 * To assess the impact that smartphone and tablet apps as a delivery mode have on the quality of survey questionnaire responses compared to any other alternative delivery mode: paper, laptop computer, tablet computer (manufactured before 2007), short message service (SMS) and plastic objects.
 * New
 * 2015/07
 * 10.1002/14651858.MR000042.pub2
 * To assess the effectiveness of a policy of beginning external cephalic version (ECV) before term (before 37 weeks' gestation) for breech presentation on fetal presentation at birth, method of delivery, and the rate of preterm birth, perinatal morbidity, stillbirth or neonatal mortality.
 * New
 * 2015/07
 * 10.1002/14651858.CD000084.pub3
 * To determine the effectiveness of platinum chemotherapy regimens compared with non-platinum chemotherapy regimens in the treatment of small cell lung cancer with respect to survival, tumour response, toxicity and quality of life.
 * Unchanged
 * 2015/08
 * 10.1002/14651858.CD006849.pub3
 * Small-cell carcinomaChemotherapy
 * To assess the effects of interventions for the prevention of herpes simplex labialis (cold sores on the lips) in people of all ages.
 * New
 * 2015/08
 * 10.1002/14651858.CD010095.pub2
 * Herpes labialisHerpes simplex virus
 * To assess the effects of proportion of energy intake from fat on measures of weight and body fatness (including obesity, waist circumference and body mass index) in people not aiming to lose weight, using all appropriate randomised controlled trials (RCTs) and cohort studies in adults, children and young people
 * New
 * 2015/08
 * 10.1002/14651858.CD011834
 * To assess the effects of regional anaesthesia and analgesia on long-term functional outcomes 3, 6 and 12 months after elective major joint (knee, shoulder and hip) replacement surgery.
 * New
 * 2015/08
 * 10.1002/14651858.CD010278.pub2
 * Joint replacement
 * To compare the efficacy of antiepileptic drugs and neuroprotective agents with placebo, usual care or other pharmacologic agents for the prevention of post-traumatic epilepsy in people diagnosed with any severity of traumatic brain injury.
 * New
 * 2015/08
 * 10.1002/14651858.CD009900.pub2
 * Post-traumatic epilepsy
 * To assess the effects (benefits and harms) of interventions for treating fractures of the distal femur in adults.
 * New
 * 2015/08
 * 10.1002/14651858.CD010606.pub2
 * Femoral fracture
 * To determine the effectiveness of preoperative statin therapy in patients undergoing cardiac surgery.
 * Changed
 * 2015/08
 * 10.1002/14651858.CD008493.pub3
 * This updated review aimed to summarise the effects of anti-VEGF use to reduce the occurrence of POVCH after vitrectomy surgery for PDR.
 * Changed
 * 2015/08
 * 10.1002/14651858.CD008214.pub3
 * To assess the effectiveness and safety of different interventions for treating leg cramps in pregnancy.
 * New
 * 2015/08
 * 10.1002/14651858.CD010655.pub2
 * To assess the effects and safety of oral fumaric acid esters for psoriasis.
 * New
 * 2015/08
 * 10.1002/14651858.CD010497.pub2
 * Psoriasis
 * To assess the effectiveness and safety of different surgical approaches to hysterectomy for women with benign gynaecological conditions.
 * Changed
 * 2015/08
 * 10.1002/14651858.CD003677.pub5
 * Hysterectomy
 * To determine whether voxel-based morphometry applied to the brain can be used to differentiate schizophrenia from other types of psychosis in participants who have received a clinical diagnosis of first episode psychosis.
 * New
 * 2015/08
 * 10.1002/14651858.CD011021.pub2
 * Voxel-based morphometryPsychosis
 * To assess the effects of different treatments for the management of breast abscesses in breastfeeding women.
 * New
 * 2015/08
 * 10.1002/14651858.CD010490.pub2
 * To compare the effect of home-based and supervised centre-based cardiac rehabilitation on mortality and morbidity, health-related quality of life, and modifiable cardiac risk factors in patients with heart disease.
 * Unchanged
 * 2015/08
 * 10.1002/14651858.CD007130.pub3
 * To determine the effects of any form of parenteral (PN) or enteral (EN) nutritional support, excluding vitamin supplementation and micronutrient supplementation, in children and young people with cancer undergoing chemotherapy and to determine the effect of the nutritional content of PN and EN. This is an update of a previous Cochrane review.
 * Changed
 * 2015/08
 * 10.1002/14651858.CD003298.pub3
 * To quantify the dose-related effects of various types of dual alpha and beta adrenergic receptor blockers (dual receptor blockers) on systolic and diastolic blood pressure versus placebo in patients with primary hypertension.
 * New
 * 2015/08
 * 10.1002/14651858.CD007449
 * To assess the efficacy and safety of sublingual immunotherapy compared with placebo or standard care for adults and children with asthma.
 * New
 * 2015/08
 * 10.1002/14651858.CD011293.pub2
 * To assess whether different parenteral fluid regimens lead to differences in death, or death or dependence, after stroke based on fluid type, fluid volume, duration of fluid administration, and mode of delivery.
 * New
 * 2015/09
 * 10.1002/14651858.CD011138.pub2
 * To assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh-negative women without anti-D antibodies.
 * Unchanged
 * 2015/09
 * 10.1002/14651858.CD000020.pub3
 * To determine the effects and safety of systemic antibiotics in the treatment of DFIs compared with other systemic antibiotics, topical foot care or placebo.
 * New
 * 2015/09
 * 10.1002/14651858.CD009061.pub2
 * Diabetic foot
 * To: 1) compare the safety and efficacy of transcatheter device closure with best medical therapy alone for preventing recurrent stroke (fatal or non-fatal) or transient ischemic attacks (TIAs) in people with PFO and a history of cryptogenic stroke or TIA; 2) identify specific subgroups of people most likely to benefit from closure for secondary prevention; and 3) assess the cost-effectiveness of this strategy, if possible.
 * New
 * 2015/09
 * 10.1002/14651858.CD009938.pub2
 * To: 1) compare the safety and efficacy of transcatheter device closure with best medical therapy alone for preventing recurrent stroke (fatal or non-fatal) or transient ischemic attacks (TIAs) in people with PFO and a history of cryptogenic stroke or TIA; 2) identify specific subgroups of people most likely to benefit from closure for secondary prevention; and 3) assess the cost-effectiveness of this strategy, if possible.
 * New
 * 2015/09
 * 10.1002/14651858.CD009938.pub2
 * To evaluate the benefits and risks of different laparoscopic entry techniques in gynaecological and non-gynaecological surgery.
 * Unchanged
 * 2015/08
 * 10.1002/14651858.CD006583.pub4
 * To assess the effectiveness and safety of all interventions for nausea, vomiting and retching in early pregnancy, up to 20 weeks’ gestation.
 * Unchanged
 * 2015/09
 * 10.1002/14651858.CD007575.pub4
 * To determine the effectiveness and safety of exercise therapy compared to a no-exercise control condition or another intervention on fatigue, measured with self-reported questionnaires, of people with MS.
 * New
 * 2015/09
 * 10.1002/14651858.CD009956.pub2
 * To determine the effectiveness (improvement or deterioration in symptoms) and safety of rutosides for treatment of post-thrombotic syndrome (PTS) in patients with DVT compared to placebo, no intervention, elastic compression stockings (ECS) or any other treatment.
 * Unchanged
 * 2015/09
 * 10.1002/14651858.CD005625.pub3
 * To assess the effects (benefits and harms) of whole-body cryotherapy (extreme cold air exposure) for preventing and treating muscle soreness after exercise in adults.
 * New
 * 2015/09
 * 10.1002/14651858.CD010789.pub2
 * Cryotherapy
 * To assess the relative effectiveness and safety of combined surgery versus cataract surgery (phacoemulsification) alone for co-existing cataract and glaucoma. The secondary objectives include cost analyses for different surgical techniques for co-existing cataract and glaucoma.
 * New
 * 2015/07
 * 10.1002/14651858.CD008671.pub3
 * To summarize data from systematic reviews of randomised controlled trial evidence on the effectiveness of dressings for healing foot ulcers in people with diabetes mellitus (DM).
 * New
 * 2015/07
 * 10.1002/14651858.CD010471.pub2
 * Diabetic foot ulcer
 * To assess the effectiveness and safety of drugs for treating PDPH in adults and children.
 * Stable
 * 2015/07
 * 10.1002/14651858.CD007887.pub3
 * To assess the analgesic efficacy and adverse effects of a single oral dose of ibuprofen plus caffeine for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes.
 * New
 * 2015/07
 * 10.1002/14651858.CD011509.pub2
 * To assess the effects of aromatase inhibitors in male children and adolescents with short stature.
 * New
 * 2015/10
 * 10.1002/14651858.CD010888.pub2
 * To evaluate the effects of pharmacological and non-pharmacological interventions, compared to an inactive control intervention, on subjective fatigue in people with PD.
 * New
 * 2015/10
 * 10.1002/14651858.CD010925.pub2
 * To assess the effects of interventions for HS in people of all ages.
 * New
 * 2015/10
 * 10.1002/14651858.CD010081.pub2
 * To assess the effect of cervical treatment for cervical intra-epithelial neoplasia (CIN, excisional or ablative) on fertility and early pregnancy outcomes.
 * New
 * 2015/09
 * 10.1002/14651858.CD008478.pub2
 * Cervical intraepithelial neoplasia
 * To summarise the efficacy of pharmaceutical interventions for acute pain in adults with at least moderate pain following surgery who have been given a single dose of oral analgesic.
 * Stable
 * 2015/09
 * 10.1002/14651858.CD008659.pub3
 * To provide an overview of adverse event rates associated with single-dose oral analgesics, compared with placebo, for acute postoperative pain in adults.
 * New
 * 2015/10
 * 10.1002/14651858.CD011407.pub2
 * To assess the benefits and harms of tonsillectomy with or without adenoidectomy compared with non-surgical management of children with obstructive sleep-disordered breathing.
 * New
 * 2015/10
 * 10.1002/14651858.CD011165.pub2
 * TonsillectomyAdenoidectomy
 * To assess the benefits and harms of any conservative treatment for ankle osteoarthritis in adults in order to provide a synthesis of the evidence as a base for future treatment guidelines.
 * New
 * 2015/10
 * 10.1002/14651858.CD010643.pub2
 * Osteoarthritis
 * To assess the effects of prenatal education for preventing congenital toxoplasmosis.
 * Unchanged
 * 2015/10
 * 10.1002/14651858.CD006171.pub4
 * ToxoplasmosisPrenatal care
 * To examine the effectiveness and adverse effects of laser photocoagulation of drusen in age-related macular degeneration.
 * Changed
 * 2015/10
 * 10.1002/14651858.CD006537.pub3
 * Macular degenerationDrusenLaser coagulation
 * To evaluate the effects of vitamin C supplementation, alone or in combination with other separate supplements on pregnancy outcomes, adverse events, side effects and use of health resources.
 * Changed
 * 2015/09
 * 10.1002/14651858.CD004072.pub3
 * Vitamin CPregnancy
 * To assess outcomes of pregnancy where fetal movement counting was done routinely, selectively or was not done at all; and to compare different methods of fetal movement counting.
 * Unchanged
 * 2015/10
 * 10.1002/14651858.CD004909.pub3
 * Fetal movement
 * To determine whether commercially-available sleep positioning systems, compared with usual care, reduce or prevent hip migration in children with cerebral palsy. Any negative effect of sleep positioning systems on hip migration will be considered within this objective.
 * New
 * 2015/11
 * 10.1002/14651858.CD009257.pub2
 * Cerebral palsySleeping positions
 * To evaluate the benefits of oral multiple-micronutrient supplementation during pregnancy on maternal, fetal and infant health outcomes.
 * Changed
 * 2015/11
 * 10.1002/14651858.CD004905.pub4
 * Pregnancy
 * To assess the effectiveness of anti-dementia pharmacological interventions and nutritional supplements for treating cognitive decline in people with Down syndrome.
 * New
 * 2015/10
 * 10.1002/14651858.CD011546.pub2
 * Down syndrome
 * To assess the effects (benefits and harms) of treatment and rehabilitation interventions for proximal humeral fractures in adults.
 * Changed
 * 2015/11
 * 10.1002/14651858.CD000434.pub4
 * Humerus fracture
 * To evaluate the effectiveness and tolerability of cannabis-based medications for chemotherapy-induced nausea and vomiting in adults with cancer.
 * New
 * 2015/11
 * 10.1002/14651858.CD009464.pub2
 * The two primary objectives of this Cochrane review were to determine the effectiveness of:
 * New
 * 2015/11
 * 10.1002/14651858.CD011094.pub2
 * To assess the effects of interventions for trachomatous trichiasis for people living in endemic settings.
 * Changed
 * 2015/11
 * 10.1002/14651858.CD004008.pub3
 * The objectives of this review are (1) to ascertain whether prone ventilation offers a mortality advantage when compared with traditional supine or semirecumbent ventilation in patients with severe acute respiratory failure requiring conventional invasive artificial ventilation, and (2) to supplement previous systematic reviews on prone ventilation for hypoxaemic respiratory failure in an adult population.
 * New
 * 2015/11
 * 10.1002/14651858.CD008095.pub2
 * To identify and evaluate all randomized controlled trials (RCTs) involving participants undergoing elective or emergency airway management via rapid sequence induction and compare participants who have cricoid pressure administered with participants who do not have cricoid pressure administered.
 * New
 * 2015/11
 * 10.1002/14651858.CD011656.pub2
 * Cricoid pressure
 * To assess the safety and efficacy of adding a long-acting beta2-agonists (LABA) to an inhaled corticosteroids (ICS) in children and adolescents with asthma. To determine whether the benefit of LABA was influenced by baseline severity of airway obstruction, the dose of ICS to which it was added or with which it was compared, the type of LABA used, the number of devices used to deliver combination therapy and trial duration.
 * Unchanged
 * 2015/11
 * 10.1002/14651858.CD007949.pub2
 * To assess the effect of non-surgical adjunctive interventions on the rate of orthodontic tooth movement and the overall duration of treatment.
 * New
 * 2015/11
 * 10.1002/14651858.CD010887.pub2
 * To assess the optimal surgical technique for Graves' disease and Graves' ophthalmopathy.
 * New
 * 2015/11
 * 10.1002/14651858.CD010576.pub2
 * To assess the beneficial and harmful effects of methylphenidate for children and adolescents with ADHD.
 * New
 * 2015/11
 * 10.1002/14651858.CD009885.pub2
 * To assess the effects of antihistamines on the common cold.
 * New
 * 2015/11
 * 10.1002/14651858.CD009345.pub2
 * To assess the relative effectiveness, primarily with respect to intraocular pressure (IOP) control and safety, of the use of different devices as adjuncts to trabeculectomy compared with standard trabeculectomy in eyes with glaucoma.
 * New
 * 2015/12
 * 10.1002/14651858.CD010472.pub2
 * This review of randomised controlled trials (RCTs) aimed to look at the benefits and harms of mycophenolic acid versus azathioprine in primary immunosuppressive regimens after kidney transplantation. Both agents were compared regarding their efficacy for maintaining graft and patient survival, prevention of acute rejection, maintaining graft function, and their safety, including infections, malignancies and other adverse events. Furthermore, we investigated potential effect modifiers, such as transplantation era and the concomitant immunosuppressive regimen in detail.
 * New
 * 2015/12
 * 10.1002/14651858.CD007746.pub2
 * To assess the effects of periodontal therapy plus eradication therapy versus eradication therapy alone for gastric H. pylori infection..
 * New
 * 2016/02
 * 10.1002/14651858.CD009477.pub2
 * Helicobacter pylori
 * to determine the effects of exercise therapy (ET) for patients with CFS as compared with any other intervention or control.
 * Unchanged
 * 2016/02
 * 10.1002/14651858.CD003200.pub4
 * Chronic fatigue syndrome treatment
 * To review the evidence for efficacy and tolerability from randomised controlled trials regarding the effects of ketogenic diet and similar diets for epilepsy.
 * No change to conclusions
 * 2016/02
 * 10.1002/14651858.CD001903.pub3
 * Epilepsy
 * To evaluate the effectiveness of motor control exercises for patients with acute non-specific low back pain.
 * New
 * 2016/02
 * 10.1002/14651858.CD012085
 * Low back pain
 * Related reviews: Saragiotto BT, Maher CG, Yamato TP, Costa LOP, Menezes Costa LC, Ostelo RWJG, Macedo LG. Motor control exercise for chronic non-specific low-back pain. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD012004. DOI: 10.1002/14651858.CD012004
 * To assess the effectiveness of interventions involving the use of alpha2-adrenergic agonists compared with placebo, reducing doses of methadone, symptomatic medications, or an alpha2-adrenergic agonist regimen different to the experimental intervention, for the management of the acute phase of opioid withdrawal. Outcomes included the withdrawal syndrome experienced, duration of treatment, occurrence of adverse effects, and completion of treatment.
 * Unchanged
 * 2016/05
 * 10.1002/14651858.CD002024.pub5
 * Opioid use disorder
 * To ascertain the optimal management strategy for adults with malignant pleural effusion in terms of pleurodesis success. Additionally, to quantify differences in patient-reported outcomes and adverse effects between management strategies.
 * New
 * 2016/05
 * 10.1002/14651858.CD010529.pub2
 * Malignant pleural effusion
 * To assess the effects of maintenance agonist pharmacotherapy for the treatment of pharmaceutical opioid dependence.
 * New
 * 2016/05
 * 10.1002/14651858.CD011117.pub2
 * Opioid use disorder
 * To review the efficacy of nicotine receptor partial agonists, including varenicline and cytisine, for smoking cessation.
 * Changed
 * 2016/05
 * 10.1002/14651858.CD006103.pub7
 * Smoking cessation
 * To assess the effectiveness and safety, of all interventions for hyperemesis gravidarum in pregnancy up to 20 weeks' gestation.
 * New
 * 2016/05
 * 10.1002/14651858.CD010607.pub2
 * Hyperemesis gravidarum
 * To assess the efficacy and safety of any dose or duration of oral steroids versus any other dose or duration of oral steroids for adults and children with an asthma exacerbation.
 * New
 * 2016/05
 * 10.1002/14651858.CD011801.pub2
 * Acute severe asthma

Asthma 175 Breast Cancer
 * To assess the effects of different types of breast implants on capsular contracture, surgical short- and long-term complications, postoperative satisfaction level and quality of life in women who have undergone reconstructive breast surgery after mastectomy.
 * New
 * 2016/05
 * 10.1002/14651858.CD010895.pub2
 * Mastectomy

Breast cancer

Breast reconstruction 176 Pregnancy and Childbirth
 * To examine the effectiveness and safety of hypnosis for pain management during labour and childbirth.
 * Unchanged
 * 2016/05
 * 10.1002/14651858.CD009356.pub3
 * Hypnotherapy in childbirth

Hypnotherapy

Hypnosis

Childbirth 177 Pregnancy and Childbirth
 * To assess the effects of a policy of labour induction at or shortly before term (37 to 40 weeks) for suspected fetal macrosomia on the way of giving birth and maternal or perinatal morbidity.
 * Unchanged
 * 2016/05
 * 10.1002/14651858.CD000938.pub2
 * Hypnotherapy in childbirth

Large for gestational age

Childbirth 178 Public Health 179 Skin 180 Tobacco Addiction 181 Heart
 * To assess the health and well-being impacts on adults following participation in environmental enhancement and conservation activities.
 * New
 * 2016/05
 * 10.1002/14651858.CD010351.pub2
 * To determine the efficacy and safety of the available options for the treatment of female pattern hair loss in women.
 * Unchanged
 * 2016/05
 * 10.1002/14651858.CD007628.pub4
 * Frontal fibrosing alopecia
 * To assess the extent to which institutional smoking bans may reduce passive smoke exposure and active smoking, and affect other health-related outcomes.
 * New
 * 2016/05
 * 10.1002/14651858.CD011856.pub2
 * Smoking ban
 * To determine the benefits and harms associated with the following.

1. A routine invasive versus a conservative or 'selective invasive' strategy for the management of unstable angina and non-ST elevation myocardial infarction (UA/NSTEMI) in the stent era.

2. A routine invasive strategy with and without glycoprotein IIb/IIIa receptor antagonists versus a conservative strategy for the management of UA/NSTEMI in the stent era. Unstable angina 182 Anaesthesia, Critical and Emergency Care 183 Stroke 184 Musculoskeletal 185 Airways 186 Public Health 187 ENT 188 Pain, Palliative and Supportive Care 189 Effective Practice and Organisation of Care 190 Effective Practice and Organisation of Care 191 Kidney and Transplant 192 Metabolic and Endocrine Disorders 193 Wounds 194 Neonatal 195 Breast Cancer 196 Drugs and Alcohol 197 198 2. To assess whether parenting programmes are effective in the primary prevention of emotional and behavioural problems. 199 200 201 202 203 204 205 206 207 208 209 210
 * Changed
 * 2016/05
 * 10.1002/14651858.CD004815.pub4
 * Myocardial infarction
 * To review the effects of psychological preparation on postoperative outcomes in adults undergoing elective surgery under general anaesthetic.
 * New
 * 2016/05
 * 10.1002/14651858.CD008646.pub2
 * General anaesthesia
 * To assess the effects of speech and language therapy (SLT) for aphasia following stroke.
 * Changed
 * 2016/06
 * 10.1002/14651858.CD000425.pub4
 * Stroke
 * To evaluate the effect of biologic interventions on fatigue in rheumatoid arthritis.
 * New
 * 2016/06
 * 10.1002/14651858.CD008334.pub2
 * Rheumatoid arthritis
 * To compare the clinical effectiveness and safety of increased versus stable doses of inhaled corticosteroids (ICS) as part of a patient-initiated action plan for home management of exacerbations in children and adults with persistent asthma.
 * Unchanged
 * 2016/06
 * 10.1002/14651858.CD007524.pub4
 * Asthma
 * To evaluate the beneficial and adverse effects of fortification of staple foods with zinc on health-related outcomes and biomarkers of zinc status in the general population.
 * New
 * 2016/06
 * 10.1002/14651858.CD010697.pub2
 * Zinc
 * To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.
 * Unchanged
 * 2016/06
 * 10.1002/14651858.CD009163.pub3
 * To assess the efficacy and safety of paracetamol for the acute treatment of frequent episodic tension-type headache in adults.
 * New
 * 2016/06
 * 10.1002/14651858.CD011889.pub2
 * To evaluate the effects of programs that implement the IMCI strategy in terms of death, nutritional status, quality of care, coverage with IMCI deliverables, and satisfaction of beneficiaries.
 * New
 * 2016/06
 * 10.1002/14651858.CD010123.pub2
 * Integrated Management of Childhood Illness
 * To evaluate the effectiveness of intervention strategies to boost and sustain high childhood immunisation coverage in LMICs. (OPEN ACCESS)
 * Changed
 * 2016/07
 * 10.1002/14651858.CD008145.pub3
 * The objective of this review is to evaluate the accuracy of two alternative imaging tests - the dimercaptosuccinic acid renal scan (DMSA) and renal-bladder ultrasound (RBUS) - in diagnosing VUR and high-grade VUR (Grade III-V VUR).
 * New
 * 2016/06
 * 10.1002/14651858.CD010657.pub2
 * To assess the effects of short-acting insulin analogues versus regular human insulin in adults with type 1 diabetes.
 * New
 * 2016/06
 * 10.1002/14651858.CD012161
 * To assess the effects of skin antisepsis as part of central venous catheter care for reducing catheter-related blood stream infections (BSIs), catheter colonisation, and patient mortality and morbidities.
 * New
 * 2016/07
 * 10.1002/14651858.CD010140.pub2
 * To determine the efficacy, effect of dose, method of administration and safety of sucrose for relieving procedural pain in neonates as assessed by validated composite pain scores, physiological pain indicators (heart rate, respiratory rate, saturation of peripheral oxygen in the blood, transcutaneous oxygen and carbon dioxide (gas exchange measured across the skin - TcpO2, TcpCO2), near infrared spectroscopy (NIRS), electroencephalogram (EEG), or behavioural pain indicators (cry duration, proportion of time crying, proportion of time facial actions (e.g. grimace) are present), or a combination of these and long-term neurodevelopmental outcomes.
 * Unchanged
 * 2016/07
 * 10.1002/14651858.CD001069.pub5
 * To assess the effect of altered radiation fraction size for women with early breast cancer who have had breast conserving surgery.
 * Unchanged
 * 2016/07
 * 10.1002/14651858.CD003860.pub4
 * To assess the effects of motivational interviewing (MI) interventions for preventing alcohol misuse and alcohol-related problems in young adults.
 * Unchanged
 * 2016/07
 * 10.1002/14651858.CD007025.pub4
 * Upper GI and Pancreatic Diseases
 * To evaluate the efficacy and safety of molecular-targeted therapy, either alone or in combination with chemotherapy, in people with advanced gastric cancer.
 * New
 * 2016/07
 * 10.1002/14651858.CD011461.pub2
 * Developmental, Psychosocial and Learning Problems
 * 1. To establish whether group-based parenting programmes are effective in improving the emotional and behavioural adjustment of young children (maximum mean age of three years and 11 months); and
 * Changed
 * 2016/08
 * 10.1002/14651858.CD003680.pub3
 * Airways
 * To assess the efficacy and safety of home telemonitoring with healthcare professional feedback between clinic visits, compared with usual care.
 * New
 * 2016/08
 * 10.1002/14651858.CD011714.pub2
 * Vascular
 * To investigate the ability of the D-dimer test to rule out a diagnosis of acute PE in patients treated in hospital outpatient and accident and emergency (A&E) settings who have had a pre-test probability (PTP) of PE determined according to a clinical prediction rule (CPR), by estimating the accuracy of the test according to estimates of sensitivity and specificity. The review focuses on those patients who are not already established on anticoagulation at the time of study recruitment.
 * New
 * 2016/08
 * 10.1002/14651858.CD010864.pub2
 * Effective Practice and Organisation of Care
 * To assess the effects of public sector regulation, training, or co-ordination of the private for-profit health sector in low- and middle-income countries.
 * New
 * 2016/08
 * 10.1002/14651858.CD009855.pub2
 * Gynaecological, Neuro-oncology and Orphan Cancer
 * To assess and compare the effects of music therapy and music medicine interventions for psychological and physical outcomes in people with cancer.
 * Changed
 * 2016/08
 * 10.1002/14651858.CD006911.pub3
 * Effective Practice and Organisation of Care
 * Our primary objective was to systematically summarise empirical evidence of the effects of strategies to reduce corruption in the health sector. Our secondary objective was to describe the range of strategies that have been tried and to guide future evaluations of promising strategies for which there is insufficient evidence.
 * New
 * 2016/08
 * 10.1002/14651858.CD008856.pub2
 * Stroke
 * To assess the effects of self management interventions on the quality of life of adults with stroke who are living in the community, compared with inactive or active (usual care) control interventions.
 * New
 * 2016/08
 * 10.1002/14651858.CD010442.pub2
 * Neonatal
 * To determine whether evidence is available to support the use of KMC in LBW infants as an alternative to conventional neonatal care before or after the initial period of stabilization with conventional care, and to assess beneficial and adverse effects.
 * Unchanged
 * 2016/08
 * 10.1002/14651858.CD002771.pub4
 * Kangaroo care
 * - Article updated
 * Musculoskeletal
 * To compare methotrexate and methotrexate-based DMARD combinations for rheumatoid arthritis in patients naïve to or with an inadequate response (IR) to methotrexate.
 * New
 * 2016/08
 * 10.1002/14651858.CD010227.pub2
 * Vascular
 * The aim of this review was to assess the efficacy of combined intermittent pneumatic leg compression (IPC) and pharmacological prophylaxis versus single modalities in preventing venous thromboembolism.
 * Unchanged
 * 2016/09
 * 10.1002/14651858.CD005258.pub3
 * Tobacco Addiction
 * To evaluate-the safety and effect of using ECs to help people Who smoke accomplish achieve long-term smoking abstinence.
 * Unchanged
 * 2016/09
 * 10.1002/14651858.CD010216.pub3
 * Developmental, Psychosocial and Learning Problems
 * To assess the effectiveness and safety of pain-relieving agents for reducing colic in infants younger than four months of age.
 * New
 * 2016/09
 * 10.1002/14651858.CD009999.pub2
 * Public Health
 * • To assess the impact of population-level interventions for dietary sodium reduction in government jurisdictions worldwide.

• To assess the differential impact of those initiatives by social and economic indicators. 211 212 213 214
 * New
 * 2016/09
 * 10.1002/14651858.CD010166.pub2
 * STI
 * To assess the effects and safety of chlamydia screening versus standard care on chlamydia transmission and infection complications in pregnant and non-pregnant women and in men.
 * New
 * 2016/09
 * 10.1002/14651858.CD010866.pub2
 * STI
 * To assess the effectiveness in women and the safety in men of concurrent antibiotic treatment for the sexual partners of women treated for bacterial vaginosis.
 * New
 * 2016/10
 * 10.1002/14651858.CD011701.pub2
 * Bacterial vaginosis
 * Common Mental Disorders
 * To assess the effects of psychological therapies in preventing PTSD and associated negative emotional, behavioural and mental health outcomes in children and adolescents who have undergone a traumatic event.
 * New
 * 2016/10
 * 10.1002/14651858.CD012371
 * Mental disorderPosttraumatic stress disorder
 * Pregnancy and Childbirth
 * To assess the effects of immediate or early SSC for healthy newborn infants compared to standard contact on establishment and maintenance of breastfeeding and infant physiology.
 * Unchanged
 * 2016/11
 * 10.1002/14651858.CD003519
 * Kangaroo care
 * - Article updated, may be other relevant articles also
 * }
 * }