Wikipedia:Featured picture candidates/Insulin secretion

Insulin Action on the cell
Voting period ends on 25 May 2011 at 03:03:36 (UTC)
 * Reason: The image is very informational and has neat representation of some complex biological processes. The image is high resolution .svg image as well
 * Articles in which this image appears:Insulin signal transduction pathway and regulation of blood glucose
 * FP category for this image:Featured_pictures/Sciences/Biology
 * Creator:Bioesharm


 * Support as nominator --Bioesharm (talk) 03:03, 16 May 2011 (UTC)
 * Oppose - diagrams should be svg files. While this is an svg file it seems to consist of a single embedded bitmap image. - Zephyris Talk 11:58, 16 May 2011 (UTC)
 * Oppose: Per Zephyris (good catch btw). The file was generated by Adobe Illustrator, not familiar with it myself but I would hope that a commercial program like that would export to actual SVG and not an SVG encapsulated bitmap, unless the image was originally scanned or converted from another format. You can definitely see the edges blur at high zoom. One advantage of SVG is that you can easily convert the text to other languages, but in this case the text is part of the image so you would need to redraw it to make this kind of change.--RDBury (talk) 13:10, 16 May 2011 (UTC)
 * Oppose as above. If you are going to redraw it, can I also recommend that the capitalisation is sorted? Sentence case is best for this kind of thing, to Save Random Capitals Appearing in the Text. J Milburn (talk) 18:34, 16 May 2011 (UTC)
 * Comment - There are also many inaccuracies and typos.
 * The insulin receptor is labelled innaccurately; both the alpha and beta subunits are part of the receptor.
 * The alpha subunit of the insulin receptor should not be shown penetrating the membrane; the beta subunit has a transmembrane domain while the alpha subunit is purely extracellular.
 * The insulin receptor is actually a dimerisation of two alpha and two beta subunits and should probably be shown as such
 * "Sub-unit" does not need to be hyphenated.
 * The "Phosphorylation of enzyme" next to the tyrosine kinase is innaccurate as largely signalling proteins rather than metabolic enzymes are phosphorylated by the kinase.
 * "Sythesis" is misspelt.
 * "Cell Survival" is not the same as "Proliferation", and I am not quite sure what is meant here; does PI3K signalling promote stem cell proliferation?
 * The thing labelled "GLUT-4 Vesicle" is not a vesicle; it is a passive glucose transporter.
 * Comment He is correct in implying that GLUT4 is translocated to the cell membrane downstream to activation by insulin, and GLUT4 is sequestered intracellularly in vesicles when insulin levels are low. This is an important point, and I feel that it should be incorporated into this image, although presently the labeling is incorrect, as Zephyris mentions.-- mcshadypl T C  21:53, 19 May 2011 (UTC)
 * The cycling of glucose transporters to and from the cell membrane via vesicles is not clearly illustrated at all; the glucose transporter shown in the cytoplasm should be associated with a vesicle's membrane.
 * "Excess extracted glucose" and "Extracted glucose" are shown originating from the glucose transporter vesicle. This is incorrect, the transporter, once sequestered in vesicles, does not transport glucose. The glucose transport occurs via diffusion when the glucose transporter is embedded in the cell membrane.
 * Notably the illustration of regulation of the glucose transporter's location, its sequestering in internal vesicles, and how this results in control of glucose uptake have major fundamental problems which make this diagram inaccurate. - Zephyris Talk 12:22, 17 May 2011 (UTC)


 * Oppose Per above. Additionally, the arrows appear to be hand-draw via computer, and I would expect something of a little more quality in an FPC.  Spencer T♦ C 13:10, 21 May 2011 (UTC)

--Makeemlighter (talk) 04:10, 25 May 2011 (UTC)