Wikipedia:Peer review/Ribonucleotide reductase/archive1

Ribonucleotide reductase
Wonderful peer reviewed thesis work

Peter J. Kos 04:15, 18 May 2006 (UTC)

The new reviw: M. Bennati, F. Lendzian, M. Schmittel, H. Zipse "Spectroscopic and Theoretical Approaches for Studying Radical Reactions in Ribonucleotide Reductase (review)" Biol. Chem. 2005, 386, 1007 - 1022. Should also be in. The article is a little to much on the biochemists side, and a little bit hard to read.--Stone 16:19, 18 May 2006 (UTC)

Why is it so special? The Abstraction of the non acidc hydrogen from the carbon is a hard task. The easiest hydrogen to abstract would be at the oxygen. The radical reactions have to be done shielded from the sourounding medium because water and oxygen would end the reaction....-Stone 16:23, 18 May 2006 (UTC)

Holy text blocks, Batman! I wouldn't normally say an encyclopedia article has too much information, but... this has way too much information. It really looks like you just copied your thesis intro chapter wholesale, which makes it good scholarship but confusing to a general audience. Solidly referenced for the most part, but in need of significant rewriting to make it accessible to non-experts (and why would an expert be looking it up on Wikipedia?) Specifically:
 * There are no wikilinks after the lead. Not everyone reading this article will know off the top of their heads what a disulfide bond is, or what NADPH looks like, etc.
 * There's a ton of jargon. Again, non-experts don't know that dNTP = deoxyribonucleotide, and don't appreciate the dNTP/NTP distinction.
 * The illustrations are too large and rather difficult to follow. The captions are awkwardly formatted and very long. At one point it looks like there was an image depicting the reaction pathway in this article - was it removed for copyright reasons or just left by the wayside? In any case, it or something like it should come back.
 * There's entirely too much detail in text about the structure, and no picture of the protein! It looks like the PDB has a wide variety of structures to choose from, though I don't see a structure of the complex.
 * Minor bits of unnecessary detail like the residue number of the reactive tyrosine in different species should go. Same with the residue numbers of the electron transfer pathway.
 * Consider converting the references to a footnote style. Parenthetical citations just make already long text blocks look longer.

Lastly, a content question - I don't believe RNR is the only enzyme that uses a radical-dependent mechanism. Cytochrome c oxidase and chlorophyllide a oxygenase come to mind, I'm sure there are others. Opabinia regalis 00:37, 27 May 2006 (UTC)