Wikipedia:Reference desk/Archives/Science/2024 April 17

= April 17 =

pouch delivery
Hi. The medical field has been using Modified-release dosage tablets/pills/capsules for decades.

Today, I heard about Nicotine pouch on the news. I have never came across this delivery method before, so it got me curious. Nicotine pouch slowly release Nicotine over time, in an analogous way as modified-release dosage tablets/pills/capsules slowly release medication over time.

1. Are there any medication that is delivered via the pouch method?

2. There are Nicotine pouch, Nicotine patch, Nicotine gum, and Nicotine Lozenges that is kept in the mouth but must not be swallowed. There are probably many other nicotine delivery methods that I am not aware of. Are there any Modified-release dosage nicotine tablets/pills/capsules that you swallow?

3. To the best of my knowledge, it seems like almost every nicotine delivery method that goes in the mouth is kept in the mouth, and must not be swallowed. Is there a reason for this?

OptoFidelty (talk) 05:28, 17 April 2024 (UTC)
 * It seems that nicotine causes nausea and vomiting when it hits the stomach. Also, the stomach acids destroy it, according to Quora. This article says that a time release pill for treating ulcerative colitis with nicotine gets a lot of nicotine where it's needed in the colon, but not so much in the bloodstream. The nicotine in the pouches and other delivery methods needs to travel across the mucous membranes, skin, or lungs to get people feeling good. Abductive  (reasoning) 10:37, 17 April 2024 (UTC)
 * Thank you! OptoFidelty (talk) 18:53, 17 April 2024 (UTC)
 * Some medications (and foods) besides nicotine are being packaged in edible film pouches or capsules. It's been studied for new methods of drug delivery  but I haven't personally seen anything other than self-medications taken with these kinds of pouches.  Recon  rabbit  01:42, 19 April 2024 (UTC)